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REM Sleep Behavior Disorder in Parkinson’s Disease: Effects on Cognitive, Psychiatric, and Functional outcomes

  • Zanjbeel Mahmood (a1) (a2), Ryan Van Patten (a2) (a3), Marina Z. Nakhla (a1) (a2), Elizabeth W. Twamley (a2) (a3) (a4), J. Vincent Filoteo (a2) (a3) (a5) and Dawn M. Schiehser (a2) (a3) (a4)...

Abstract

Objective:

Rapid eye movement sleep behavior disorder (RBD) affects 33–46% of patients with Parkinson’s disease (PD) and may be a risk factor for neuropsychological and functional deficits. However, the role of RBD on neuropsychological functioning in PD has yet to be fully determined. We, therefore, examined differences in neurocognitive performance, functional capacity, and psychiatric symptoms among nondemented PD patients with probable RBD (PD/pRBD+) and without (PD/pRBD−), and healthy comparison participants (HC).

Methods:

Totally, 172 participants (58 PD/pRBD+; 65 PD/pRBD−; 49 HC) completed an RBD sleep questionnaire, psychiatric/clinical questionnaires, performance-based and self-reported functional capacity measures, and underwent a comprehensive neuropsychological battery assessing attention/working memory, language, visuospatial function, verbal and visual learning and memory, and executive function.

Results:

Controlling for psychiatric symptom severity, the PD/pRBD+ group had poorer executive functioning and learning performance than the PD/pRBD− group and poorer neuropsychological functioning across all individual cognitive domains than the HCs. In contrast, PD/pRBD− patients had significantly lower scores than HCs only in the language domain. Moreover, PD/pRBD+ patients demonstrated significantly poorer medication management skills compared to HCs. Both PD groups reported greater depressive and anxiety severity compared to HCs; PD/pRBD+ group also endorsed greater severity of apathy compared to HCs.

Conclusions:

The presence of pRBD is associated with poorer neuropsychological functioning in PD such that PD patients with pRBD have poorer cognitive, functional, and emotional outcomes compared to HC participants and/or PD patients without pRBD. Our findings underscore the importance of RBD assessment for improved detection and treatment of neuropsychological deficits (e.g., targeted cognitive interventions).

Copyright

Corresponding author

*Corresponding Author: Dawn Schiehser, PhD, Research Service, VA San Diego Healthcare System, MC 151-B, La Jolla, CA92161, Email: dschiehser@ucsd.edu. Phone: +858-552-8585 ext. 2664

References

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Aarsland, D., Creese, B., Politis, M., Chaudhuri, K.R., Ffytche, D.H., Weintraub, D., & Ballard, C. (2017). Cognitive decline in Parkinson disease. Nature Reviews Neurology, 13(4), 217231. doi: 10.1038/nrneurol.2017.27
Aarsland, D., Marsh, L., & Schrag, A. (2009). Neuropsychiatric symptoms in Parkinson’s disease. Movement Disorders, 24(15), 21752186. doi: 10.1002/mds.22589
Anang, J.B.M., Gagnon, J.F., Bertrand, J.A., Romenets, S.R., Latreille, V., Panisset, M., … Postuma, R.B. (2014). Predictors of dementia in Parkinson disease: A prospective cohort study. Neurology, 83(14), 12531260. doi: 10.1212/WNL.0000000000000842
Ansari, M., Rahmani, F., Dolatshahi, M., Pooyan, A., & Aarabi, M.H. (2017). Brain pathway differences between Parkinson’s disease patients with and without REM sleep behavior disorder. Sleep and Breathing, 21(1), 155161. doi: 10.1007/s11325-016-1435-8
Barnes, L.L.B., Harp, D., & Jung, W.S. (2002). Reliability generalization of scores on the Spielberger State-Trait Anxiety Inventory. Educational and Psychological Measurement, 62(4), 603618. doi: 10.1177/0013164402062004005
Berg, D., Postuma, R.B., Adler, C.H., Bloem, B.R., Chan, P., Dubois, B., … Deuschl, G. (2015). MDS research criteria for prodromal Parkinson’s disease. Movement Disorders, 30(12), 16001611. doi: 10.1002/mds.26431
Berg, D., Postuma, R.B., Bloem, B., Chan, P., Dubois, B., Gasser, T., … Lang, A.E. (2014). Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson’s disease. Movement Disorders, 29(4), 454462. doi: 10.1002/mds.25844
Boeve, B.F., Molano, J.R., Ferman, T.J., Smith, G.E., Lin, S.C., Bieniek, K., … Lucas, J.A. (2011). Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep medicine, 12(5), 445453.
Borek, L.L., Kohn, R., & Friedman, J.H. (2006). Mood and sleep in Parkinson’s disease. The Journal of Clinical Psychiatry, 67(6), 958963.
Bugalho, P. & Paiva, T. (2011). Dream features in the early stages of Parkinson’s Disease. Journal of Neural Transmission, 118(11), 1613. doi: 10.1007/s00702-011-0679-5
Chahine, L.M., Amara, A.W., & Videnovic, A. (2017). A systematic review of the literature on disorders of sleep and wakefulness in Parkinson’s disease from 2005 to 2015. Sleep Medicine Reviews, 35, 3350. doi: 10.1016/j.smrv.2016.08.001
Chahine, L.M., Weintraub, D., Hawkins, K.A., Siderowf, A., Eberly, S., Oakes, D., … PARS Investigators. (2016). Cognition in individuals at risk for Parkinson’s: Parkinson associated risk syndrome (PARS) study findings. Movement Disorders, 31(1), 8694. doi: 10.1002/mds.26373
Chaudhuri, K.R., Healy, D.G., & Schapira, A.H.V. (2006). Non-motor symptoms of Parkinson’s disease: Diagnosis and management. The Lancet Neurology, 5(3), 235245. doi: 10.1016/S1474-4422(06)70373-8
Daley, D.J., Myint, P.K., Gray, R.J., & Deane, K.H.O.L. (2012). Systematic review on factors associated with medication non-adherence in Parkinson’s disease. Parkinsonism and Related Disorders, 18(10), 10531061. doi: 10.1016/j.parkreldis.2012.09.004
Delis, D., Kaplan, E., & Kramer, J. (2001). Delis-Kaplan Executive Function System (D-KEFS): Examiner’s manual. San Antonio, TX: The Psychological Corporation.
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B.A. (2000). CVLT-II: California Verbal Learning Test: Adult Version. San Antonio, TX: The Psychological Corporation.
den Brok, M.G.H.E., van Dalen, J.W., van Gool, W.A., Moll van Charante, E.P., de Bie, R.M.A., & Richard, E. (2015). Apathy in Parkinson’s disease: A systematic review and meta-analysis. Movement Disorders, 30(6), 759769. doi: 10.1002/mds.26208
Dirnberger, G. & Jahanshahi, M. (2013). Executive dysfunction in Parkinson’s disease: A review. Journal of Neuropsychology, 7(2), 193224. doi: 10.1111/jnp.12028
Dissanayaka, N.N.W., Lawson, R.A., Yarnall, A.J., Duncan, G.W., Breen, D.P., Khoo, T.K., … Burn, D.J. (2017). Anxiety is associated with cognitive impairment in newly-diagnosed Parkinson’s disease. Parkinsonism and Related Disorders, 36, 6368. doi: 10.1016/j.parkreldis.2017.01.001
Emre, M., Aarsland, D., Brown, R., Burn, D.J., Duyckaerts, C., Mizuno, Y., … Dubois, B. (2007). Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Movement Disorders, 22(12), 16891707. doi: 10.1002/mds.21507
Erro, R., Santangelo, G., Picillo, M., Vitale, C., Amboni, M., Longo, K., … Barone, P. (2012). Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients. Journal of Neurology, 259(9), 18081813. doi: 10.1007/s00415-011-6407-0
Fereshtehnejad, S.M., Romenets, S.R., Anang, J.B.M., Latreille, V., Gagnon, J.F., & Postuma, R.B. (2015). New clinical subtypes of Parkinson disease and their longitudinal progression a prospective cohort comparison with other phenotypes. JAMA Neurology, 72(8), 863873. doi: 10.1001/jamaneurol.2015.0703
Ferini–Strambi, L., Di Gioia, M.R., Castronovo, V., Oldani, A., Zucconi, M., & Cappa, S.F. (2004). Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): Does the idiopathic form of RBD really exist?. Neurology, 62(1), 4145. doi: 10.1212/01.WNL.0000101726.69701.FA
Ford, A.H., Duncan, G.W., Firbank, M.J., Yarnall, A.J., Khoo, T.K., Burn, D.J., & O’Brien, J.T. (2013). Rapid eye movement sleep behavior disorder in Parkinson’s disease: Magnetic resonance imaging study. Movement Disorders, 28(6), 832836. doi: 10.1002/mds.25367
Gagnon, J.-F., Bédard, M.-A., Fantini, M.L., Petit, D., Panisset, M., Rompré, S., … Montplaisir, J. (2002). REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease. Neurology, 59(4), 585LP589. doi: 10.1212/WNL.59.4.585
Gagnon, J.F., Fantini, M.L., Bédard, M.A., Petit, D., Carrier, J., Rompré, S., … Montplaisir, J. (2004). Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia. Neurology, 62(3), 401406. doi: 10.1212/01.WNL.0000106460.34682.E9
Gagnon, J.-F., Vendette, M., Postuma, R.B., Desjardins, C., Massicotte-Marquez, J., Panisset, M., & Montplaisir, J. (2009). Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson’s disease. Annals of Neurology, 66(1), 3947. doi: 10.1002/ana.21680
Génier Marchand, D., Postuma, R.B., Escudier, F., De Roy, J., Pelletier, A., Montplaisir, J., & Gagnon, J. (2018). How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder. Annals of Neurology, 83(5), 10161026. doi: 10.1002/ana.25239
Goetz, C.G., Poewe, W., Rascol, O., Sampaio, C., Stebbins, G.T., Counsell, C., y Seidl, L. (2004). Movement Disorder Society Task Force Report on the Hoehn and Yahr Staging Scale: Status and recommendations. Movement Disorders, 19(9), 10201028. https://doi-org.libproxy.sdsu.edu/10.1002/mds.20213
Goetz, C.G., Tilley, B.C., Shaftman, S.R., Stebbins, G.T., Fahn, S., Martinez-Martin, P., … LaPelle, N. (2008). Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders: Official Journal of the Movement Disorder Society, 23(15), 21292170. doi: 10.1002/mds.22340
Goldman, J.G., Holden, S.K., Litvan, I., McKeith, I., Stebbins, G.T., & Taylor, J.P. (2018). Evolution of diagnostic criteria and assessments for Parkinson’s disease mild cognitive impairment. Movement Disorders, 33(4), 503510. doi: 10.1002/mds.27323
Gong, Y., Xiong, K., Mao, C., Shen, Y., Hu, W., Huang, J., … Liu, C. (2014). Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Sleep Medicine, 15(6), 647653. doi: doi: 10.1016/j.sleep.2013.12.021
Grosset, K.A., Bone, I., & Grosset, D.G. (2005). Suboptimal medication adherence in Parkinson’s disease. Movement Disorders, 20(11), 15021507. doi: 10.1002/mds.20602
Heaton, R.K., Chelune, G.J., Talley, J.L., Kay, G.G., & Curtiss, G. (1993). Wisconsin Card Sorting Test Manual: Revised and Extended. Odessa, FL: Psychological Assessment Resources.
Hu, M.T.M., Szewczyk-Królikowski, K., Tomlinson, P., Nithi, K., Rolinski, M., Murray, C., … Ben-Shlomo, Y. (2014). Predictors of cognitive impairment in an early stage Parkinson’s disease cohort. Movement Disorders, 29(3), 351359. doi: 10.1002/mds.25748
Hughes, A.J., Ben-Shlomo, Y., Daniel, S.E., & Lees, A.J. (1992). What features improve the accuracy of clinical diagnosis in Parkinson’s disease: A clinicopathologic study. Neurology, 42(6), 1142 LP1142. doi: 10.1212/WNL.42.6.1142
Jozwiak, N., Montplaisir, J., Latreille, V., Bourgouin, P.-A., Gagnon, J.-F., Postuma, R.B., … Chouinard, S. (2017). REM Sleep Behavior Disorder and cognitive impairment in Parkinson’s disease. Sleep, 40(8). doi: 10.1093/sleep/zsx101
Kehagia, A.A., Barker, R.A., & Robbins, T.W. (2010). Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson’s disease. The Lancet Neurology, 9(12), 12001213. doi: doi: 10.1016/S1474-4422(10)70212-X
Kudlicka, A., Clare, L., & Hindle, J.V. (2011). Executive functions in Parkinson’s disease: Systematic review and meta-analysis. Movement Disorders, 26(13), 23052315. doi: 10.1002/mds.23868
Kulkarni, A.S., Balkrishnan, R., Anderson, R.T., Edin, H.M., Kirsch, J., & Stacy, M.A. (2008). Medication adherence and associated outcomes in medicare health maintenance organization-enrolled older adults with Parkinson’s disease. Movement Disorders, 23(3), 359365. doi: 10.1002/mds.21831
Lavault, S., Leu-Semenescu, S., du Montcel, S., de Cock, V., Vidailhet, M., & Arnulf, I. (2010). Does clinical rapid eye movement behavior disorder predict worse outcomes in Parkinson’s disease? Journal of Neurology, 257(7), 11541159. doi: 10.1007/s00415-010-5482-y
Lawton, M.P. & Brody, E.M. (1969). Assessment of older people: Self-maintaining and instrumental activities of daily living. The Gerontologist, 9(3_Part_1), 179186. doi: 10.1093/geront/9.3_Part_1.179
Lawson, R.A., Yarnall, A.J., Duncan, G.W., Breen, D.P., Khoo, T.K., Williams-Gray, C.H., … Study Group, ICICLE-PD (2016). Cognitive decline and quality of life in incident Parkinson’s disease: The role of attention. Parkinsonism and Related Disorders, 27, 4753. doi: 10.1016/j.parkreldis.2016.04.009
Leentjens, A.F.G., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I.H., Starkstein, S.E., … Goetz, C.G. (2008a). Anxiety rating scales in Parkinson’s disease: Critique and recommendations. Movement Disorders, 23(14), 20152025. doi: 10.1002/mds.22233
Leentjens, A.F.G., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I.H., Starkstein, S.E., … Goetz, C.G. (2008b). Apathy and anhedonia rating scales in Parkinson’s disease: Critique and recommendations. Movement Disorders, 23(14), 20042014. doi: 10.1002/mds.22229
Leopold, N.A., Polansky, M., & Hurka, M.R. (2004). Drug adherence in Parkinson’s disease. Movement Disorders, 19(5), 513517. doi: 10.1002/mds.20041
Lim, J.S., Shin, S.A., Lee, J.Y., Nam, H., Lee, J.Y., & Kim, Y.K. (2016). Neural substrates of rapid eye movement sleep behavior disorder in Parkinson’s disease. Parkinsonism and Related Disorders, 23, 3136. doi: 10.1016/j.parkreldis.2015.11.027
Litvan, I., Goldman, J.G., Tröster, A.I., Schmand, B.A., Weintraub, D., Petersen, R.C., … & Aarsland, D. (2012). Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines. Movement Disorders, 27(3), 349356. doi: 10.1002/mds.24893
Llebaria, G., Pagonabarraga, J., Kulisevsky, J., García-Sánchez, C., Pascual-Sedano, B., Gironell, A., & Martínez-Corral, M. (2008). Cut-off score of the Mattis Dementia Rating Scale for screening dementia in Parkinson’s disease. Movement Disorders, 23(11), 15461550. doi: 10.1002/mds.22173
Marques, A., Dujardin, K., Boucart, M., Pins, D., Delliaux, M., Defebvre, L., … Monaca, C. (2010). REM sleep behaviour disorder and visuoperceptive dysfunction: A disorder of the ventral visual stream? Journal of Neurology, 257(3), 383391. doi: 10.1007/s00415-009-5328-7
Nomura, T., Inoue, Y., Kagimura, T., Uemura, Y., & Nakashima, K. (2011). Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson’s disease patients. Sleep Medicine, 12(7), 711713. doi: 10.1016/j.sleep.2011.01.015
Nomura, T., Inoue, Y., Kagimura, T., & Nakashima, K. (2013). Clinical significance of REM sleep behavior disorder in Parkinson’s disease. Sleep Medicine, 14(2), 131135. doi: 10.1016/j.sleep.2012.10.011
Oguru, M., Tachibana, H., Toda, K., Okuda, B., & Oka, N. (2010). Apathy and depression in Parkinson disease. Journal of Geriatric Psychiatry and Neurology, 23(1), 3541. doi: 10.1177/0891988709351834
Patterson, T.L., Goldman, S., McKibbin, C.L., Hughs, T., & Jeste, D.V. (2001). UCSD Performance-Based Skills Assessment: Development of a new measure of everyday functioning for severely mentally ill adults. Schizophrenia Bulletin, 27(2), 235245. doi: 10.1093/oxfordjournals.schbul.a006870
Patterson, T.L., Lacro, J., McKibbin, C.L., Moscona, S., Hughs, T., & Jeste, D.V. (2002). Medication Management Ability Assessment: Results from a performance-based measure in older outpatients with schizophrenia. Journal of Clinical Psychopharmacology, 22(1), 1119.
Pedersen, K.F., Larsen, J.P., Tysnes, O.-B., & Alves, G. (2017). Natural course of mild cognitive impairment in Parkinson disease: A 5-year population-based study. Neurology, 88(8), 767774. doi: 10.1212/WNL.0000000000003634
Pirogovsky-Turk, E., Moore, R.C., Filoteo, J.V., Litvan, I., Song, D.D., Lessig, S.L., & Schiehser, D.M. (2017). Neuropsychiatric predictors of cognitive decline in Parkinson disease: A longitudinal study. American Journal of Geriatric Psychiatry, 25(3), 279289. doi: 10.1016/j.jagp.2016.10.004
Pirogovsky-Turk, E., Schiehser, D.M., Obtera, K.M., Burke, M.M., Lessig, S.L., Song, D.D., … Filoteo, J.V. (2014). Instrumental activities of daily living are impaired in Parkinson’s disease patients with mild cognitive impairment. Neuropsychology, Vol. 28, pp. 229237. doi: 10.1037/neu0000045
Plomhause, L., Dujardin, K., Duhamel, A., Delliaux, M., Derambure, P., Defebvre, L., & Monaca Charley, C. (2013). Rapid eye movement sleep behavior disorder in treatment-naïve Parkinson disease patients. Sleep Medicine, 14(10), 10351037. doi: doi: 10.1016/j.sleep.2013.04.018
Poewe, W. (2008). Non-motor symptoms in Parkinson’s disease. European Journal of Neurology, 15(s1), 1420. doi: 10.1111/j.1468-1331.2008.02056.x
Postuma, R.B., Berg, D., Stern, M., Poewe, W., Olanow, C.W., Oertel, W., … Deuschl, G. (2015). MDS clinical diagnostic criteria for Parkinson’s disease. Movement Disorders: Official Journal of the Movement Disorder Society, 30(12), 15911601. doi: 10.1002/mds.26424
Postuma, R.B., Iranzo, A., Hu, M., Högl, B., Boeve, B.F., Manni, R., … Puligheddu, M. (2019). Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: A multicentre study. Brain, 142(3), 744759. doi: 10.1093/brain/awz030
Postuma, R.B., Gagnon, J.-F., Vendette, M., Charland, K., & Montplaisir, J. (2008). Manifestations of Parkinson disease differ in association with REM sleep behavior disorder. Movement Disorders, 23(12), 16651672. doi: 10.1002/mds.22099
Postuma, R.B., Lang, A.E., Gagnon, J.F., Pelletier, A., & Montplaisir, J.Y. (2012). How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain, 135(6), 18601870. doi: 10.1093/brain/aws093
Riedel, O., Klotsche, J., Spottke, A., Deuschl, G., Förstl, H., Henn, F., … Wittchen, H.-U. (2008). Cognitive impairment in 873 patients with idiopathic Parkinson’s disease. Journal of Neurology, 255(2), 255264. doi: 10.1007/s00415-008-0720-2
Rolinski, M., Szewczyk-Krolikowski, K., Tomlinson, P.R., Nithi, K., Talbot, K., Ben-Shlomo, Y., & Hu, M.T.M. (2014). REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 85(5), 560566. doi: 10.1136/jnnp-2013-306104
Schapira, A.H.V, Chaudhuri, K.R., & Jenner, P. (2017). Non-motor features of Parkinson disease. Nature Reviews Neuroscience, 18(7), 435. doi: 10.1038/nrn.2017.62
Schiehser, D.M., Han, S.D., Lessig, S., Song, D.D., Zizak, V., & Filoteo, J.V. (2009). Predictors of health status in nondepressed and nondemented individuals with Parkinson’s disease. Archives of Clinical Neuropsychology, 24(7), 699709. doi: 10.1093/arclin/acp064
Schmidt, R., Freidl, W., Fazekas, F., Reinhart, B., Grieshofer, P., Koch, M., … Lechner, H. (1994). The Mattis Dementia Rating Scale: Normative data from 1,001 healthy volunteers. Neurology, 44(5), 964964. doi: 10.1212/WNL.44.5.964
Sinforiani, E., Zangaglia, R., Manni, R., Cristina, S., Marchioni, E., Nappi, G., … Pacchetti, C. (2006). REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson’s disease. Movement Disorders, 21(4), 462466. doi: 10.1002/mds.20719
Sixel-Döring, F., Trautmann, E., Mollenhauer, B., & Trenkwalder, C. (2011). Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology, 77(11), 1048 LP1054. doi: 10.1212/WNL.0b013e31822e560e
Sixel-Döring, F., Trautmann, E., Mollenhauer, B., & Trenkwalder, C. (2014). Rapid Eye Movement Sleep behavioral events: A new marker for neurodegeneration in early Parkinson disease? Sleep, 37(3), 431438. doi: 10.5665/sleep.3468
Spielberger, C.D., Gorsuch, R.L., Lushene, R., Vagg, P.R., & Jacobs, G.A. (1983). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
Starkstein, S.E., Mayberg, H.S., Preziosi, T., Andrezejewski, P., Leiguarda, R., & Robinson, R.G. (1992). Reliability, validity, and clinical correlates of apathy in Parkinson’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 4(2), 134139. doi: 10.1176/jnp.4.2.134
Stiasny-Kolster, K., Mayer, G., Schäfer, S., Möller, J.C., Heinzel-Gutenbrunner, M., & Oertel, W.H. (2007). The REM sleep behavior disorder screening questionnaire—A new diagnostic instrument. Movement Disorders, 22(16), 23862393. doi: 10.1002/mds.21740
Tandberg, E., Larsen, J.P., & Karlsen, K. (1998). A community-based study of sleep disorders in patients with Parkinson’s disease. Movement Disorders, 13(6), 895899. doi: 10.1002/mds.870130606
Tomlinson, C.L., Stowe, R., Patel, S., Rick, C., Gray, R., & Clarke, C.E. (2010). Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Movement Disorders, 25(15), 26492653. doi: 10.1002/mds.23429
Van Den Eeden, S.K., Tanner, C.M., Bernstein, A.L., Fross, R.D., Leimpeter, A., Bloch, D.A., & Nelson, L.M. (2003). Incidence of Parkinson’s disease: Variation by age, gender, and race/ethnicity. American Journal of Epidemiology, 157(11), 10151022. doi: 10.1093/aje/kwg068
Vendette, M., Gagnon, J.F., Décary, A., Massicotte-Marquez, J., Postuma, R.B., Doyon, J., … Montplaisir, J. (2007). REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology, 69(19), 18431849. doi: 10.1212/01.wnl.0000278114.14096.74
Walker, M. (2017). Why we sleep: Unlocking the power of sleep and dreams. New York, NY: Scribner.
Wang, Y., Wang, Z.W., Yang, Y.C., Wu, H.J., Zhao, H.Y., & Zhao, Z.X. (2015). Validation of the rapid eye movement sleep behavior disorder screening questionnaire in China. Journal of Clinical Neuroscience, 22(9), 14201424. doi: 10.1016/j.jocn.2015.03.008
Wechsler, D. (1997). Wechsler Memory Scale–Third Edition, San Antonio, TX: The Psychological Corporation.
Yesavage, J.A., Brink, T.L., Rose, T.L., Lum, O., Huang, V., Adey, M., & Leirer, V.O. (1982). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17(1), 3749. doi: 10.1016/0022-3956(82)90033-4
Zhang, J.R., Chen, J., Yang, Z.J., Zhang, H.J., Fu, Y.T., Shen, Y., … Liu, C.F. (2016). Rapid eye movement sleep behavior disorder symptoms correlate with domains of cognitive impairment in Parkinson’s disease. Chinese Medical Journal, 129(4), 379385. doi: 10.4103/0366-6999.176077
Zgaljardic, D.J., Borod, J.C., Foldi, N.S., & Mattis, P. (2003). A review of the cognitive and behavioral sequelae of Parkinson’s disease: Relationship to frontostriatal circuitry. Cognitive and Behavioral Neurology, 16(4). doi: 10.1097/00146965-200312000-00001
Zgaljardic, D.J., Borod, J.C., Foldi, N.S., Mattis, P.J., Gordon, M.F., Feigin, A., & Eidelberg, D. (2006). An examination of executive dysfunction associated with frontostriatal circuitry in Parkinson’s disease. Journal of Clinical and Experimental Neuropsychology, 28(7), 11271144. doi: 10.1080/13803390500246910

Keywords

REM Sleep Behavior Disorder in Parkinson’s Disease: Effects on Cognitive, Psychiatric, and Functional outcomes

  • Zanjbeel Mahmood (a1) (a2), Ryan Van Patten (a2) (a3), Marina Z. Nakhla (a1) (a2), Elizabeth W. Twamley (a2) (a3) (a4), J. Vincent Filoteo (a2) (a3) (a5) and Dawn M. Schiehser (a2) (a3) (a4)...

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