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Profiles of Executive Function Across Children with Distinct Brain Disorders: Traumatic Brain Injury, Stroke, and Brain Tumor

Published online by Cambridge University Press:  15 May 2017

Gabriel C. Araujo ,
Tanya N. Antonini ,
Vicki Anderson ,
Kathryn A. Vannatta ,
Christina G. Salley ,
Erin D. Bigler ,
H. Gerry Taylor ,
Cynthia Gerhardt ,
Kenneth Rubin  and
Maureen Dennis
...Show all authors
Gabriel C. Araujo*
Affiliation:
Department of Psychology, St. Louis Children’s Hospital, St. Louis, Missouri
Tanya N. Antonini
Affiliation:
Section of Psychology, Baylor College of Medicine/Texas Children’s Hospital, Houston, Texas
Vicki Anderson
Affiliation:
Murdoch Children’s Research Institute, Department of Psychology, The Royal Children’s Hospital, School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia
Kathryn A. Vannatta
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio
Christina G. Salley
Affiliation:
Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York City, New York
Erin D. Bigler
Affiliation:
Department of Psychological Science and Neuroscience Center, Brigham Young University, Provo, Utah
H. Gerry Taylor
Affiliation:
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio
Cynthia Gerhardt
Affiliation:
The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio
Kenneth Rubin
Affiliation:
Department of Human Development and Quantitative Methodology, University of Maryland, College Park, Maryland
Maureen Dennis
Affiliation:
Program in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada
Warren Lo
Affiliation:
Division of Neurology, Department of Pediatrics, The Ohio State University and Nationwide Children’s Hospital, Columbus, Ohio
Mark T. Mackay
Affiliation:
Department of Neurology, The Royal Children’s Hospital, Melbourne, Australia, and Department of Paediatrics, University of Melbourne, Parkville, Australia
Anne Gordon
Affiliation:
Paediatric Neurology, Evelina London Children’s Hospital, and Institute of Psychology, Psychiatry & Neuroscience, Kings College London, London, United Kingdom
Christine Hajek Koterba
Affiliation:
Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio
Alison Gomes
Affiliation:
Clinical Sciences, Murdoch Childrens Research Institute, and School of Psychological Sciences, Monash University, Melbourne, Australia
Mardee Greenham
Affiliation:
Clinical Sciences, Murdoch Childrens Research Institute, and School of Psychological Sciences, University of Melbourne, Melbourne, Australia
Keith Owen Yeates
Affiliation:
Department of Psychology, Alberta Children’s Hospital Research Institute, and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
*
Correspondence and reprint requests to: Gabriel C. Araujo, One Children’s Place, St. Louis, MO 63110. E-mail: gabriel.araujo@bjc.org
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Abstract

Objectives: This study examined whether children with distinct brain disorders show different profiles of strengths and weaknesses in executive functions, and differ from children without brain disorder. Methods: Participants were children with traumatic brain injury (N=82; 8–13 years of age), arterial ischemic stroke (N=36; 6–16 years of age), and brain tumor (N=74; 9–18 years of age), each with a corresponding matched comparison group consisting of children with orthopedic injury (N=61), asthma (N=15), and classmates without medical illness (N=68), respectively. Shifting, inhibition, and working memory were assessed, respectively, using three Test of Everyday Attention: Children’s Version (TEA-Ch) subtests: Creature Counting, Walk-Don’t-Walk, and Code Transmission. Comparison groups did not differ in TEA-Ch performance and were merged into a single control group. Profile analysis was used to examine group differences in TEA-Ch subtest scaled scores after controlling for maternal education and age. Results: As a whole, children with brain disorder performed more poorly than controls on measures of executive function. Relative to controls, the three brain injury groups showed significantly different profiles of executive functions. Importantly, post hoc tests revealed that performance on TEA-Ch subtests differed among the brain disorder groups. Conclusions: Results suggest that different childhood brain disorders result in distinct patterns of executive function deficits that differ from children without brain disorder. Implications for clinical practice and future research are discussed. (JINS, 2017, 23, 529–538)

Keywords

Executive functionsShiftingInhibitionWorking memoryPediatric brain disordersTEA-Ch
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 23 , Issue 7 , August 2017 , pp. 529 - 538
Copyright
Copyright © The International Neuropsychological Society 2017 

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References

REFERENCES

Aarsen, F.K., Paquier, P.F., Arts, W.F., Van Veelen, M.L., Michiels, E., Lequin, M., & Catsman-Berrevoets, C.E. (2009). Cognitive deficits and predictors 3 years after diagnosis of a pilocytic astrocytoma in childhood. Journal of Clinical Oncology, 27(21), 3526–3532. doi: 10.1200/JCO.2008.19.6303 CrossRefGoogle ScholarPubMed
Alexander, G.E., DeLong, M.R., & Strick, P.L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357–381. doi: 10.1146/annurev.ne.09.030186.002041 Google Scholar
Alvarez, J.A., & Emory, E. (2006). Executive function and the frontal lobes: A meta analytic review. Neuropsychology Review, 16(1), 17–42. doi: 10.1007/s11065-006-9002-x Google Scholar
Anderson, V., Fenwick, T., Manly, T., & Robertson, I. (1998). Attentional skills following traumatic brain injury in childhood: A componential analysis. Brain Injury, 12(11), 937–949. doi: 10.1080/026990598121990 CrossRefGoogle ScholarPubMed
Barkley, R.A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65. doi: 10.1037//0033-2909.121.1.65 CrossRefGoogle ScholarPubMed
Bayless, S., & Stevenson, J. (2007). Executive functions in school-age children born very prematurely. Early Human Development, 83, 247–254. doi: 10.1016/j.earlhumdev.2006.05.021 Google Scholar
Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society, Series B (Methodological), 57, 289–300. doi: 10.2307/2346101 Google Scholar
Brocki, K.C., & Bohlin, G. (2004). Executive functions in children aged 6 to 13: A dimensional and developmental study. Developmental Neuropsychology, 26, 571–593. doi: 10.1207/s15326942dn2602_3 Google Scholar
Brocki, K., Fan, J., & Fossella, J. (2008). Placing neuroanatomical models of executive function in a developmental context. Annals of the New York Academy of Sciences, 1129, 246–255. doi: 10.1196/annals.1417.025 Google Scholar
Conklin, H.M., Ashford, J.M., Di Pinto, M., Vaughan, C.G., Gioia, G.A., Merchant, T.E., &Wu, S. (2013). Computerized assessment of cognitive late effects among adolescent brain tumor survivors. Journal of Neurooncology, 113(2), 333–340. doi: 10.1007/s11060-013-1123-5 Google Scholar
Conklin, H.M., Ashford, J.M., Howarth, R.A., Merchant, T.E., Ogg, R.J., Santana, V.M., & Xiong, X. (2012). Working memory performance among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 18(6), 996–1005. doi: 10.1017/S1355617712000793 Google Scholar
Conklin, H.M., Ogg, R.J., Ashford, J.M., Scoggins, M.A., Zou, P., Clark, K.N.,& Zhang, H. (2015). Computerized cognitive training for amelioration of cognitive late effects among childhood cancer survivors: A randomized control trial. Journal of Clinical Oncology, 33, 3894–3902. doi: 10.1200/JCO.2015.61.6672 CrossRefGoogle Scholar
Corbett, B.A., Constantine, L.J., Hendren, R., Rocke, D., & Ozonoff, S. (2009). Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Research, 166(2), 210–222. doi: 10.1016/j.psychres.2008.02.005 CrossRefGoogle ScholarPubMed
De Ruiter, M.A., Van Mourik, R., Schouten-Van Meeteran, A.Y., Grootenhuis, M.A., & Oosterlaan, J. (2013). Neurocognitive consequences of a paediatric brain tumour and its treatment: A meta‐analysis. Developmental Medicine & Child Neurology, 55(5), 408–417. doi: 10.1111/dmcn.12020 Google Scholar
Diamond, A., & Lee, K. (2011). Interventions shown to aid executive function development in children 4 to 12 years old. Science, 333, 959–964. doi: 10.1126/science.1204529 Google Scholar
Ewing-Cobbs, L., Prasad, M.R., Landry, S.H., Kramer, L., & DeLeon, R. (2004). Executive functions following traumatic brain injury in young children: A preliminary analysis. Developmental Neuropsychology, 26(1), 487–512. doi: 10.1207/s15326942dn2601_7 Google Scholar
Fisk, J.E., & Sharp, C.A. (2004). Age-related impairment in executive functioning: Updating, inhibition, shifting, and access. Journal of Clinical and Experimental Neuropsychology, 26, 874–890. doi: 10.1080/13803390490510680 Google Scholar
Fletcher, J.M., & Copeland, D.R. (1988). Neurobehavioral effects of central nervous system prophylactic treatment of cancer in children. Journal of Clinical and Experimental Neuropsychology, 10(4), 495–537. doi: 10.1080/01688638808408255 Google Scholar
Fournier-Vicente, S., Larigauderie, P., & Gaonac’h, D. (2008). More dissociations and interactions within central executive functioning: A comprehensive latent variable analysis. Acta Psychologica, 129, 32–48. doi: 10.1016/j.actpsy.2008.04.004 CrossRefGoogle ScholarPubMed
Garnett, M.R., Blamire, A.M., Rajagopalan, B., Styles, P., & Cadoux-Hudson, T.A. (2000). Evidence for cellular damage in normal-appearing white matter correlates with injury severity in patients following traumatic brain injury: A magnetic resonance spectroscopy study. Brain, 123(7), 1403–1409. doi: 10.1093/brain/123.7.1403.Google Scholar
Gioia, G.A., Isquith, P.K., Kenworthy, L., & Barton, R.M. (2002). Profiles of everyday executive function in acquired and developmental disorders. Child Neuropsychology, 8, 121–137. doi: 10.1076/chin.8.2.121.8727 Google Scholar
Goldberg, M.C., Mostofsky, S.H., Cutting, L.E., Mahone, E.M., Astor, B.C., Denckla, M.B., & Landa, R.J. (2005). Subtle executive impairment in children with autism and children with ADHD. Journal of Autism and Developmental Disorders, 35, 279–293. doi: 10.1007/s10803-005-3291-4 Google Scholar
Grunewaldt, K.H., Lohaugen, G.C.C., Austeng, D., Brubakk, A., & Skranes, J. (2013). Working memory training improves cognitive function in VLBW preschoolers. Pediatrics, 131(3), 747–754. doi: 10.1542/peds.2012-1965 CrossRefGoogle ScholarPubMed
Hajek, C.A., Yeates, K.O., Anderson, V., Mackay, M., Greenham, M., Alison Gomes, A., & Lo, W. (2014). Cognitive outcomes following arterial ischemic stroke in infants and children. Journal of Child Neurology, 29, 887–894. doi: 10.1177/0883073813491828 Google Scholar
Happé, F., Booth, R., Charlton, R., & Hughes, C. (2006). Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: Examining profiles across domains and ages. Brain and Cognition, 61, 25–39. doi: 10.1016/j.bandc.2006.03.004 Google Scholar
Hobson, P., & Leeds, L. (2001). Executive functioning in older people. Reviews in Clinical Gerontology, 11, 361–372. doi: 10.1017/S0959259801011479 Google Scholar
Iverson, G., & Lange, R.T. (2011). Mild traumatic brain injury. In M.R. Schoenberg & J.G. Scott (Eds.), The little black book of neuropsychology: A syndrome-based approach (pp. 697–719). New York, NY: Springer.Google Scholar
Jacobs, R., Harvey, A.S., & Anderson, V. (2007). Executive function following focal frontal lobe lesions: Impact of timing of lesion on outcome. Cortex, 43, 792–805. doi: 10.1016/S0010-9452(08)70507-0 Google Scholar
Jurado, M.B., & Rosselli, M. (2007). The elusive nature of executive functions: A review of our current understanding. Neuropsychology Review, 17, 213–233. doi: 10.1007/s1106 5-007-9040-z Google Scholar
Klingberg, T., Fernell, E., Olesen, P., Johnson, M., Gustaffson, P., Dahlstrom, K., & Westerberg, H. (2005). Computerized training of working memory in children with ADHD: A randomized, controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 177–186. doi: 10.1097/00004583-200502000-00010 Google Scholar
Konrad, K., Gauggel, S., Manz, A., & Scholl, M. (2000). Inhibitory control in children with traumatic brain injury (TBI) and children with attention deficit/hyperactivity disorder (ADHD). Brain Injury, 14, 859–875. doi: 10.1080/13803395.2011.562864 Google Scholar
Kurowski, B.G., Wade, S.L., Kirkwood, M.W., Brown, T.M., Stancin, T., & Taylor, G. (2013). Online problem-solving therapy for executive dysfunction after child traumatic brain injury. Pediatrics, 132, e158–e166. doi: 10.1542/peds.2012-4040 Google Scholar
Law, N., Bouffet, E., Laughlin, S., Laperriere, N., Brière, M.E., Strother, D., & Dickson, J. (2011). Cerebello–thalamo–cerebral connections in pediatric brain tumor patients: Impact on working memory. Neuroimage, 56(4), 2238–2248. doi: 10.1016/j.neuroimage.2011.03.065 CrossRefGoogle ScholarPubMed
Leblanc, N., Chen, S., Swank, P.R., Ewing-Cobbs, L., Barnes, M., Dennis, M., & Schachar, R. (2005). Response inhibition after traumatic brain injury (TBI) in children: Impairment and recovery. Developmental Neuropsychology, 28, 829–848. doi: 10.1207/s15326942dn2803_5 Google Scholar
Levin, H.S., & Hanten, G. (2005). Executive functions after traumatic brain injury in children. Pediatric Neurology, 33, 79–93. doi: 10.1016/j.pediatrneurol.2005.02.002 Google Scholar
Lewis, S.J., Dove, A., Robbins, T.W., Barker, R.A., & Owen, A.M. (2004). Striatal contributions to working memory: A functional magnetic resonance imaging study in humans. European Journal of Neuroscience, 19, 755–760. doi: 10.1111/j.1460-9568. 2004.03108.x Google Scholar
Lezak, M.D. (1983). Neuropsychological assessment (2nd ed.). New York: Oxford University Press.Google Scholar
Miller, E.K., & Cohen, J.D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167–202.CrossRefGoogle ScholarPubMed
Lieh-Lai, M.W., Theodorou, A.A., Sarnaik, A.P., Meert, K.L., Moylan, P.M., & Canady, A.I. (1992). Limitations in of the Glasgow Coma Scale in predicting outcome in children with traumatic brain injury. The Journal of Pediatrics, 120, 195–199. doi: 10.1016/S0022-3476(05)80426-3 Google Scholar
Mahone, E.M., Koth, C.W., Cutting, L., Singer, H.S., & Denckla, M.B. (2001). Executive function in fluency and recall measures among children with Tourette syndrome or ADHD. Journal of the International Neuropsychological Society, 7, 102–111. doi: 10.1017/ S1355617701711101 Google Scholar
Mangeot, S., Armstrong, K., Colvin, A.N., Yeates, K.O., & Taylor, H.G. (2002). Long-term executive function deficits in children with traumatic brain injuries: Assessment using the Behavior Rating Inventory of Executive Function (BRIEF). Child Neuropsychology, 8, 271–284. doi: 10.1076/chin.8.4.271.13503 Google Scholar
Manly, T., Anderson, V., Nimmo-Smith, I., Turner, A., Watson, P., & Roberston, I.H. (2001). The differential assessment of children’s attention: The test of everyday attention for children (TEA-Ch), normative sample and ADHD performance. The Journal of Child Psychology and Psychiatry, 42(8), 1065–1081. doi: 10.1111/1469-7610.00806 Google Scholar
Manly, T., Robertson, I.H., Anderson, V., & Nimmo-Smith, I. (1999). Test of Everyday Attention for Children (TEA–Ch). London: Harcourt Assessment.Google Scholar
McDonald, B.C., Flashman, L.A., & Saykin, A.J. (2002). Executive dysfunction following traumatic brain injury: Neural substrates and treatment strategies. Neurorehabilitation, 17(4), 333–344.CrossRefGoogle ScholarPubMed
McNett, M. (2007). A review of the predictive ability of Glasgow Coma Scale scores in head-injured patients. Journal of Nursing Neuroscience, 39, 68–75. doi: 10.1001/jamasurg.2014.13 CrossRefGoogle ScholarPubMed
Middleton, F.A., & Strick, P.L. (2001). A revised neuroanatomy of frontal-subcortical circuits. In D.G. Lichter & J.L. Cummings (Eds.), Frontal-subcortical circuits in psychiatric and neurological disorders (pp. 44–58). New York, NY: Guilford Publications.Google Scholar
Miller, E.K., & Cohen, J.D. (2001). An integrative theory of prefrontal cortex function. Annual review of neuroscience, 24(1), 167–202. doi: 10.1146/annurev.neuro.24.1.167 CrossRefGoogle ScholarPubMed
Miyake, A., Friedman, N.P., Emerson, M.J., Witzki, A.H., Howerter, A., & Wager, T.D. (2000). The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: A latent variable analysis. Cognitive Psychology, 41, 49–100. doi: 10.1006/ cogp.1999.0734 CrossRefGoogle ScholarPubMed
Pennington, B.F., & Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37, 51–87. doi: 10.1111/ j.1469-7610.1996.tb01380.x Google Scholar
Power, T., Catroppa, C., Coleman, L., Ditchfield, M., & Anderson, V. (2007). Do lesion site and severity predict deficits in attentional control after preschool traumatic brain injury (TBI)? Brain Injury, 21, 279–292. doi: 10.1080/02699050701253095 Google Scholar
Salley, C.G., Hewitt, L.L., Patenaude, A.F., Vasey, M.W., Yeates, K.O., Gerhardt, C.A., & Vannatta, K. (2015). Temperament and social behavior in pediatric brain tumor survivors and comparison peers. Journal of Pediatric Psychology, 40(3), 297–308. doi: 10.1093/jpepsy/jsu083 Google Scholar
Sherer, M., Struchen, M.A., Yablon, S.A., Wang, Y., & Nick, T.G. (2008). Comparison of indices of traumatic brain injury severity: Glasgow Coma Scale, length of coma and post-traumatic amnesia. Journal of Neurology, Neurosurgery, and Psychiatry, 79, 678–685. doi: 10.1136/jnnp.2006.111187 Google Scholar
Slomine, B.S., Gerring, J.P., Grados, M.A., Vasa, R., Brady, K.D., Christensen, J.R., & Denckla, M.B. (2002). Performance on measures of ‘executive function’ following pediatric traumatic brain injury. Brain Injury, 16, 759–772. doi: 10.1080/02699050210127286 Google Scholar
Spiegler, B.J., Bouffet, E., Greenberg, M.L., Rutka, J.T., & Mabbott, D.J. (2004). Change in neurocognitive functioning after treatment with cranial radiation in childhood. Journal of Clinical Oncology, 22(4), 706–713. doi: 10.1200/JCO.2004.05.186 Google Scholar
Stuss, D.T., & Levine, B. (2002). Adult clinical neuropsychology: Lessons from studies of the frontal lobes. Annual Review of Psychology, 53, 401–433. doi: 10.1146/annurev.psych.53.100901.135220 Google Scholar
Taylor, H.G., & Alden, J. (1997). Age-related differences in outcomes following childhood brain insults: An introduction and overview. Journal of the International Neuropsychological Society, 3(6), 555–567. doi: 10.1093/brain/awn293 Google Scholar
Teasdale, G., & Jennett, B. (1974). Assessment of coma and impaired consciousness: A practical scale. The Lancet, 304(7872), 81–84. doi: 10.1016/S0140-6736(74)91639-0 Google Scholar
van der Naalt, J., van Zomeren, A.H., Sluiter, W.J., & Minderhound, J.M. (1999). One year outcome in mild to moderate head injury: The predictive value of acute injury characteristics related to complaints and return to work. Journal of Neurology, Neurosurgery, and Psychiatry, 66, 207–213. doi: 10.1136/jnnp.66.2.207 Google Scholar
Verte, S., Geurts, H.M., Roeyers, H., Oosterlaan, J., & Sergeant, J.A. (2006). The relationship of working memory, inhibition, and response variability in child psychopathology. Journal of Neuroscience Methods, 151(1), 5–14. doi: 10.1016/j.jneumeth.2005.08.023 Google Scholar
Wechsler, D. (1999). Wechsler abbreviated scale of intelligence. San Antonio, TX: Psychological Corporation.Google Scholar
Westmacott, R., Askalan, R., Macgregor, D., Anderson, P., & Deveber, G. (2010). Cognitive outcome following unilateral arterial ischaemic stroke in childhood: Effects of age at stroke and lesion location. Developmental Medicine & Child Neurology, 52(4), 386–393. doi: 10.1111/j.1469-8749.2009.03403.x Google Scholar
Yeates, K.O., Bigler, E.D., Abildskov, T., Dennis, M., Gerhardt, C.A., Vannatta, K., & Taylor, H.G. (2014). Social competence in pediatric traumatic brain injury: From brain to behavior. Clinical Psychological Science, 2, 97–107. doi: 10.1177/2167702613499734 CrossRefGoogle Scholar
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