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Predictors of cognitive function in candidates for coronary artery bypass graft surgery

  • CHRISTINE S. ERNEST (a1), PETER C. ELLIOTT (a1) (a2), BARBARA M. MURPHY (a1) (a3), MICHAEL R. LE GRANDE (a1), ALAN J. GOBLE (a1), ROSEMARY O. HIGGINS (a1), MARIAN U.C. WORCESTER (a1) (a4) and JAMES TATOULIS (a5)...

Abstract

Candidates for coronary artery bypass graft surgery have been found to exhibit reduced cognitive function prior to surgery. However, little is known regarding the factors that are associated with pre-bypass cognitive function. A battery of neuropsychological tests was administered to a group of patients listed for bypass surgery (n = 109). Medical, sociodemographic and emotional predictors of cognitive function were investigated using structural equation modeling. Medical factors, namely history of hypertension and low ejection fraction, significantly predicted reduced cognitive function, as did several sociodemographic characteristics, namely older age, less education, non-English speaking background, manual occupation, and male gender. One emotional variable, confusion and bewilderment, was also a significant predictor whereas anxiety and depression were not. When significant predictors from the three sets of variables were included in a combined model, three of the five sociodemographic characteristics, namely age, non-English speaking background and occupation, and the two medical factors remained significant. Apart from sociodemographic characteristics, medical factors such as a history of hypertension and low ejection fraction significantly predicted reduced cognitive function in bypass candidates prior to surgery. (JINS, 2007, 13, 257–266.)

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Corresponding author

Correspondence and reprint requests to: Dr. Christine Ernest, Heart Research Centre, Box 2137 Post Office, The Royal Melbourne Hospital, Victoria 3050, Australia. E-mail: christine.ernest@heartresearchcentre.org

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Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
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