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Neuropsychological Deficits Associated with Destruction of the Right Nigrostriatal Pathway

Published online by Cambridge University Press:  17 April 2013

Carmen Sáez-Zea ,
Francisco Escamilla-Sevilla ,
Josefina Martínez-Simón ,
Marisa Arnedo  and
Adolfo Mínguez-Castellanos
Carmen Sáez-Zea*
Affiliation:
Movement Disorders Unit, Department of Neurology, Virgen de las Nieves University Hospital, Granada, Spain Area of Psychobiology, Department of Psychology, Faculty of Humanities and Education, University of Jaén, Spain
Francisco Escamilla-Sevilla
Affiliation:
Movement Disorders Unit, Department of Neurology, Virgen de las Nieves University Hospital, Granada, Spain
Josefina Martínez-Simón
Affiliation:
Movement Disorders Unit, Department of Neurology, Virgen de las Nieves University Hospital, Granada, Spain
Marisa Arnedo
Affiliation:
Department of Experimental Psychology, Faculty of Psychology, University of Granada, Spain
Adolfo Mínguez-Castellanos
Affiliation:
Movement Disorders Unit, Department of Neurology, Virgen de las Nieves University Hospital, Granada, Spain
*
Correspondence and reprint requests to: Carmen Sáez-Zea. Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Carretera de Jaén s/n, 18013 Granada, Spain. E-mail: csaez@ujaen.es
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Abstract

Hemiparkinsonism secondary to a vascular mesencephalic lesion is infrequent; these patients offer an exceptional opportunity to study neuropsychological alterations attributable to unilateral dopaminergic denervation, shedding light on the pathophysiology of cognitive disorders in early-stage idiopathic Parkinson's disease (PD). From the investigation of our case, we conclude that destruction of the right nigrostriatal pathway is accompanied by deficits in executive functioning and verbal/visual memory similar to those observed in many patients with early-stage idiopathic PD. The more complex neuropsychological dysfunction developed by other PD patients must therefore be related to the additional involvement of other brain structures. (JINS, 2013, 19, 1–6)

Keywords

Cerebral hemorrhageCognitive impairmentDopaminergic neuronsNeuropsychological testsSecondary parkinsonismSubstantia nigra
Type
Neurobehavioral Grand Rounds
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 6 , July 2013 , pp. 729 - 734
Copyright
Copyright © The International Neuropsychological Society 2013 

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