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Investigating temporal lobe contribution to confrontation naming using MRI quantitative volumetrics



Confrontation naming ability entails the operation of distinct cognitive operations and the integrity of a distributed neural network. Previous research has indicated a critical role for the left temporal lobe region in naming ability, but there is less agreement about the relative role of distinct temporal lobe regions. In the current paper, we used quantitative MR volumetrics to investigate the relative contribution of the hippocampus and extrahippocampal temporal lobe (segmented gray and white matter) volumes to confrontation naming performance in 53 patients with temporal lobe epilepsy. Findings showed (1) a stronger relationship for left temporal lobe volume than right temporal lobe volume in predicting naming performance; (2) both left temporal lobe white matter volume and left hippocampus volume contributed a significant amount of unique variance to spontaneous naming performance; and (3) left temporal lobe white matter volume but not left hippocampus volume predicted recognition naming performance. (JINS, 2005, 11, 358–366.)


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Reprint requests to: Michael Seidenberg, Department of Psychology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064. E-mail:


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Andreasen, N., Rajarethinam, R., Cizadlo, T.S.A., Swayze, V.W., Flashman, L.A., O'Leary, D.S., Ehrhardt, J.C., & Yuh, W.T. (1996). Automated atlas-based volume estimation of human brain regions from MR images. Journal of Computer Assisted Tomography, 20, 98106.
Bell, B., Davies, K., Hermann, B., & Walters, G. (2000). Confrontation naming after anterior temporal lobectomy is related to age of acquisition of the object names. Neuropsychologia, 38, 8392.
Bell, B., Hermann, B., Seidenberg, M., Davies, K., Cariski, D., Rosenbek, J., Woodard, A., Rutecki, P., & Bishop, M. (2002). Ipsilateral reorganization of language in early onset left temporal lobe epilepsy. Epilepsy & Behavior, 3, 158164.
Bernasconi, N., Bernasconi, A., Caramanos, Z., Antel, S.B., Andermann, F., & Arnold, D. (2003). Mesial temporal damage in temporal lobe epilepsy: A volumetric MRI study of the hippocampus, amygdala, and parahippocampal region. Brain, 126, 462469.
Coste, S., Ryvlin, P., Hermier, M., Ostrowsky, K., Adeleine, P., Froment, J.C., & Mauguiere, F. (2002). Temporopolar changes in temporal lobe epilepsy. Neurology, 59, 855861.
Damasio, H., Grabowski, T.J., Tranel, D., Hichwa, R.D., & Damasio, A.R. (1996). A neural basis for lexical retrieval. Nature, 380, 499505.
Davies, K., Bell, B., Bush, A., Hermann, B., Dohan, F.C., & Jaap, A. (1998). Naming decline after left anterior temporal lobectomy correlates with pathological status of resected hippocampus. Epilepsia, 39, 407419.
Fama, R., Sullivan, E.V., Shear, P.K., Cahn-Weiner, D.A., Marsh, L., Lim, K.O., Yesavage, J.A., & Tinklenberg, J.R. (2000). Structural brain correlates of verbal and nonverbal fluency measures in Alzheimer's disease. Neuropsychology, 14, 2940.
Fiebach, C., Friederici, A., Muller, K., Yves von Cramon, D., & Hernandez, A. (2003). Distinct brain representations for early and late learned words. Neuroimage, 19, 16271637.
Filley, C. (2001). The behavioral neurology of white matter. Oxford, UK: Oxford University Press.
Goodglass, H. & Wingfield, A. (1997). Anomia: Neuroanatomical and cognitive correlates. San Diego, CA: Academic Press.
Grabowski, T.J., Damasio, H., Tranel, D., Ponto, L.L., Hichwa, R.D., & Damasio, A.R. (2001). A role for left temporal pole in the retrieval of words for unique entities. Human Brain Mapping, 13, 199212.
Grossman, M., McMillian, C., Moore, P., Ding, L., Glosser, G., Work, M., & Gee, J. (2004). What's in a name: Voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration. Brain, 127, 628649.
Hamberger, M., Goodman, R., Perrine, K., & Tammy, T. (2001). Anatomic dissociation of auditory and visual naming in the lateral temporal cortex. Neurology, 56, 5661.
Harris, G., Andreasen, N., & Cizadlo, T. (1999). Improving tissue classification in MRI: A three-dimensional multispectral discriminant analysis method with automated training class selection. Journal of Computer Assisted Tomography, 23, 144154.
Hermann, B., Chelune, G., Loring, D., Trenerry, M.R., Perrine, K., Barr, W.B., Strauss, E., & Westerveld, M. (1999). Visual confrontation naming following left anterior temporal lobectomy: A comparison of surgical approaches. Neuropsychology, 13, 39.
Hermann, B., Seidenberg, M., Bell, B., Rutecki, P., Sheth, R., Wendt, G., O'Leary, D., & Magnotta, V. (2003). Extratemporal quantitative MR volumetrics and neuropsychological status in temporal lobe epilepsy. Journal of the International Neuropsychological Society, 9, 353362.
Hermann, B., Seidenberg, M., Schoenfeld, J., & Davies, K. (1997). Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy. Archives of Neurology, 54, 369376.
Hermann, B. & Wyler, A. (1988). Effects of anterior temporal lobectomy on language function: A controlled study. Annals of Neurology, 23, 585588.
Hirsch, K. & Funnell, E. (1995). Those old, familiar things: Age of acquisition, familiarity, and lexical access in progressive aphasia. Journal of Neurolinguistics, 9, 2332.
Kaplan, E., Goodglass, H., & Weintraub, S. (1983). Boston Naming Test (2nd ed.). Philadelphia: Lea and Febiger.
Kensinger, E., Ullman, M., & Corkin, S. (2001). Bilateral medial temporal lobe damage does not affect lexical or grammatical processing: Evidence from amnesic patient H.M. Hippocampus, 11, 347360.
Lambon Ralph, M., Graham, K.S., Ellis, A.W., & Hodges, J.R. (1998). Naming in semantic dementia-what matters? Neuropsychologia, 36, 775784.
Langfitt, J. & Rausch, R. (1996). Word-finding deficits persist after left anterotemporal lobectomy. Archives of Neurology, 53, 7276.
MacKay, D., Stewart, R., & Burke, D. (1998). H.M. revisited: Relations between language comprehension, memory, and the hippocampal system. Journal of Cognitive Neuroscience, 10, 377394.
Magnotta, V., Harris, G., Andreasen, N., O'Leary, D., Yuh, W.T., & Heckel, D. (2002). Structural MR image processing using the BRAINS2 toolbox. Computerized Medical Imaging Graphics, 26, 251264.
Marsh, L., Morrell, M., & Shear, P. (1997). Cortical and hippocampal volume deficits in temporal lobe epilepsy. Epilepsia, 38, 576587.
Moran, N., Lemieux, L., Kitchen, N.D., Fish, D.R., & Shorvon, S.D. (2001). Extrahippocampal temporal lobe atrophy in temporal lobe epilepsy and mesial temporal sclerosis. Brain, 124, 167175.
Ojemann, G.A., Ojemann, J., Lettich, E., & Berger, M. (1989). Cortical language localization in left-dominant hemisphere. Journal of Neurosurgery, 71, 316326.
Pantel, J., O'Leary, D., Crestinger, K., Bockholt, H.J., Keefe, H., Magnotta, V., & Andreasen, N. (2000). A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus, 10, 752758.
Sass, K.J., Sass, A., Weserveld, M., Lecncz, T., Novelly, R.A., Kim, J.H., & Spencer, D.D. (1992). Specificity in the correlation of verbal memory and hippocampal neuron loss: Dissociation of memory, language, and verbal intellectual ability. Journal of Clinical and Experimental Neuropsychology, 14, 662672.
Sawrie, S., Martin, R., Gilliam, F., Faught, E., Maton, B., Hugg, J.W., Bush, N., Sinclair, K., & Kuzniecky, R. (2000). Visual confrontation naming and hippocampal function: A neural network study using quantitative H magnetic resonance spectroscopy. Brain, 123, 770780.
Saykin, A.J., Stafiniak, P., Robinson, L., Flannery, K., Gur, R., O'Connor, M., & Sperling, M. (1995). Language before and after temporal lobectomy: Specificity of acute changes and relation to early risk factors. Epilepsia, 36, 10711077.
Schmolck, H., Kensinger, E.A., Corkin, S., & Squire, L.R. (2002). Semantic knowledge in patient H.M. and other patients with bilateral medial and lateral temporal lobe lesions. Hippocampus, 12, 520533.
Seidenberg, M., Hermann, B., Wyler, A., Davies, K., Curtis Dohan, F., & Leveroni, C.L. (1998). Neuropsychological outcome following anterior temporal lobectomy in patients with and without the syndrome of mesial temporal lobe epilepsy. Neuropsychology, 12, 303316.
Shear, P., Sullivan, E.V., Marsh, L., Morrell, M.J., Lim, K.O., & Pfefferbaum, A. (1997). Hippocampal volumes correlate with nonmnemonic abilities in temporal lobe epilepsy. Journal of the International Neurological Society, 3, 36.
Snyder, P., Barr, W.B., Schaul, N., & Lieberman, J. (1994). Quantitative MRI correlates of naming disorders in temporal lobe epilepsy. Epilepsia, 35(Suppl. 8), 102.
Squire, L.R. & Alvarez, P. (1995). Retrograde amnesia and memory consolidation: A neurobiological perspective. Current Opinion in Neurobiology, 5, 169177.
Vargha-Khadem, F., Gadiaun, D.G., Watkins, K.E., Connelly, A., Van Paesschen, W., & Mishkin, M. (1997). Differential effects of early hippocampal pathology on episodic and semantic memory. Science, 277, 376380.
Wilson, R., Sullivan, M., DeToledo-Morrell, L., Stebbins, G., Bennett, D., & Morrell, F. (1996). Association of memory and cognition in Alzheimer's Disease with volumetric estimates of temporal lobe structures. Neuropsychology, 10, 459463.



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