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Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation

  • Sean P. Carruthers (a1), Caroline T. Gurvich (a2), Denny Meyer (a1) (a3), Australian Schizophrenia Research Bank (a4), Chad Bousman (a5) (a6) (a7), Ian P. Everall (a5) (a7) (a8) (a9) (a10), Erica Neill (a1) (a7) (a8), Christos Pantelis (a5) (a7) (a8) (a10) (a11), Philip J. Sumner (a1), Eric J. Tan (a1) (a12), Elizabeth H.X. Thomas (a2), Tamsyn E. Van Rheenen (a1) (a11) and Susan L. Rossell (a1) (a12)...

Abstract

Objectives: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to investigate the schizophrenia spectrum. The successful completion of the task requires the interaction of multiple intact executive processes, including attention, inhibition, cognitive flexibility, and concept formation. Considerable cognitive heterogeneity exists among the schizophrenia spectrum population, with substantive evidence to support the existence of distinct cognitive phenotypes. The within-group performance heterogeneity of individuals with schizophrenia spectrum disorder (SSD) on the WCST has yet to be investigated. A data-driven cluster analysis was performed to characterise WCST performance heterogeneity. Methods: Hierarchical cluster analysis with k-means optimisation was employed to identify homogenous subgroups in a sample of 210 schizophrenia spectrum participants. Emergent clusters were then compared to each other and a group of 194 healthy controls (HC) on WCST performance and demographic/clinical variables. Results: Three clusters emerged and were validated via altered design iterations. Clusters were deemed to reflect a relatively intact patient subgroup, a moderately impaired patient subgroup, and a severely impaired patient subgroup. Conclusions: Considerable within-group heterogeneity exists on the WCST. Identification of subgroups of patients who exhibit homogenous performance on measures of executive functioning may assist in optimising cognitive interventions. Previous associations found using the WCST among schizophrenia spectrum participants should be reappraised. (JINS, 2019, 25, 750–760)

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Corresponding author

Correspondence and reprint requests to: Sean P. Carruthers, Centre for Mental Health, Level 10, ATC Building, Swinburne University of Technology, Hawthorn VIC 3122, Australia. E-mail: scarruthers@swin.edu.au

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Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation

  • Sean P. Carruthers (a1), Caroline T. Gurvich (a2), Denny Meyer (a1) (a3), Australian Schizophrenia Research Bank (a4), Chad Bousman (a5) (a6) (a7), Ian P. Everall (a5) (a7) (a8) (a9) (a10), Erica Neill (a1) (a7) (a8), Christos Pantelis (a5) (a7) (a8) (a10) (a11), Philip J. Sumner (a1), Eric J. Tan (a1) (a12), Elizabeth H.X. Thomas (a2), Tamsyn E. Van Rheenen (a1) (a11) and Susan L. Rossell (a1) (a12)...

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