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Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis

  • JULIE D. HENRY (a1), LOUISE H. PHILLIPS (a2), WILLIAM W. BEATTY (a3), SKYE MCDONALD (a1), WENDY A. LONGLEY (a4), AMY JOSCELYNE (a1) and PETER G. RENDELL (a5)...

Abstract

Multiple sclerosis (MS) is a white matter disease associated with neurocognitive difficulties. More recently the potential for white matter pathology to also disrupt important aspects of emotion understanding has been recognized. However, no study to date has assessed whether capacity for facial affect recognition and theory of mind (ToM) is disrupted in MS, or whether any observed deficits are related to more general cognitive impairment. In the present study MS participants (n = 27) and nonclinical controls (n = 30) were administered measures of facial affect recognition, ToM, and cognitive functioning. MS participants were significantly impaired on the ToM task, and also presented with specific deficits decoding facial emotions of anger and fear. Performance on the measures of facial affect recognition and ToM were related to general cognitive functioning, and in particular, measures sensitive to executive dysfunction and information processing speed. These data highlight the need for future research to more fully delineate the extent and implications of emotion understanding difficulties in this population. (JINS, 2009, 15, 277–285.)

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Corresponding author

*Correspondence and reprint requests to: Julie D. Henry, School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia. E-mail: julie.henry@unsw.edu.au

References

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Adolphs, R., Baron-Cohen, S., & Tranel, D. (2002). Impaired recognition of social emotions following amygdala damage. Journal of Cognitive Neuroscience, 14, 12641274.
Adolphs, R., Damasio, H., Tranel, D., Cooper, G., & Damasio, A.R. (2000). A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mapping. Journal of Neuroscience, 20, 26832690.
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994). Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature, 372, 669672.
Apperly, I.A., Samson, D., Chiavarino, C., & Humphreys, G. (2004). Frontal and temporo-parietal lobe contributions to theory of mind: Neuropsychological evidence from a false-belief task with reduced language and executive demands. Journal of Cognitive Neuroscience, 16, 17731784.
Arnett, P.A., Higginson, C.I., Voss, W.D., Bender, W.I., Wurst, J.M., & Tippin, J.M. (1999). Depression in multiple sclerosis: Relationship to working memory capacity. Neuropsychology, 13, 546556.
Arnett, P.A., Rao, S.M., Grafman, J., Bernardin, L., Luchetta, T., Binder, J.R., & Lobeck, L. (1997). Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities. Neuropsychology, 11, 535544.
Bailey, P.E. & Henry, J.D. (2008). Growing less empathic with age: Disinhibition of the self-perspective. Journal of Gerontology: Psychological Sciences, 63, P219P226.
Baron-Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997). A further advanced test of theory of mind: Evidence from very high functioning adults with autism or Asperger syndrome. Journal of Child Psychology and Psychiatry, 38, 813822.
Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The “Reading the Mind in the Eyes” test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 42, 241251.
Beatty, W.W., Goodkin, D.E., Beatty, P.A., & Monson, N. (1989). Frontal lobe dysfunction and memory impairment in patients with chronic progressive multiple sclerosis. Brain and Cognition, 11, 7386.
Beatty, W.W., Orbelo, D.M., Sorocco, K.H., & Ross, E.D. (2003). Comprehension of affective prosody in multiple sclerosis. Multiple Sclerosis, 9, 148153.
Beatty, W.W., Paul, R.H., Wilbanks, S.L., Hames, K.A., Blanco, C.R., & Goodkin, D.E. (1995). Identifying multiple sclerosis patients with mild or global cognitive impairment using the Screening Examination for Cognitive Impairment (SEFCI). Neurology, 45, 718723.
Beeney, J. & Arnett, P.A. (2008). Stress and memory bias interact to predict depression in multiple sclerosis. Neuropsychology, 22, 118126.
Beers, S.R., Goldstein, G., & Katz, L.J. (1994). Neuropsychological differences between college students with learning disabilities and those with mild head injury. Journal of Learning Disabilities, 27, 315324.
Bobholz, J.A. & Rao, S.M. (2003). Cognitive dysfunction in multiple sclerosis: A review of recent developments. Current Opinion in Neurology, 16, 283288.
Bobholz, J.A., Rao, S.M., Lobeck, L., Elsinger, L., Elsinger, C., Gleason, A., Kanz, J., Durgerian, S., & Maas, E. (2006). fMRI study of episodic memory in relapsing-remitting MS: Correlation with T2 lesion volume. Neurology, 67, 16401645.
Buitelaar, J.K., van der Wees, M., Swaab-Barneveld, H., & van der Gaag, J. (1999). Verbal memory and performance IQ predict theory of mind and emotion recognition ability in children with autistic spectrum disorders and psychiatric control children. Journal of Child Psychology and Psychiatry, 40, 869881.
Bull, R., Phillips, L.H., & Conway, C. (2008). The role of control functions in mentalizing: Dual task studies of Theory of Mind and executive function. Cognition, 107, 663672.
Calder, A.J., Keane, J., Lawrence, A.D., & Manes, F. (2004). Impaired recognition of anger following damage to the ventral striatum. Brain, 127, 19581969.
Carstensen, L.L., Gross, J.J., & Fung, H.H. (1998). The social context of emotional experience. Annual Review of Gerontology and Geriatrics, 17, 325352.
Carton, J.S., Kessler, E.A., & Pape, C.L. (1999). Nonverbal decoding skills and relationship well-being in adults. Journal of Nonverbal Behavior, 23, 91100.
Chalfont, A.M., Bryant, R.A., & Fulcher, G. (2004). Post traumatic stress disorder following diagnosis of multiple sclerosis. Journal of Traumatic Stress, 17, 423428.
Crawford, J.R. & Henry, J.D. (2005). Assessment of executive deficits. In Halligan, P.W. & Wade, N. (Eds.), The effectiveness of rehabilitation for cognitive deficits (pp. 233246). London: Oxford University Press.
Decety, J. & Jackson, P.L. (2004). The functional architecture of human empathy. Behavioural and Cognitive Neuroscience Reviews, 3, 71100.
Ekman, P. & Friesen, W.V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press.
Feldman, R.S., Philippot, P., & Custrini, R.J. (1991). Social competence and nonverbal behavior. In Feldman, R.S. & Rime, B. (Eds.), Fundamentals of nonverbal behavior. New York: Cambridge University Press.
Filley, C.M. (2005). White matter and behavioral neurology. Annals of the New York Academy of Sciences, 1064, 162183.
Green, R.E.A., Turner, G.R., & Thompson, W.F. (2004). Deficits in facial emotion perception in adults with recent traumatic brain injury. Neuropsychologia, 42, 133141.
Henry, J.D. & Beatty, W.W. (2006). Verbal fluency deficits in multiple sclerosis. Neuropsychologia, 44, 11661174.
Henry, J.D. & Crawford, JR. (2004). A meta-analytic review of verbal fluency performance following focal cortical lesions. Neuropsychology, 18, 284295.
Henry, J.D., Phillips, L.H., Crawford, J.R., Iatswaart, M., & Summers, F. (2006). Theory of mind following traumatic brain injury: The role of emotion recognition and executive dysfunction. Neuropsychologia, 44, 16231628.
Henry, J.D., Ruffman, T., McDonald, S., Peek-O’Leary, M., Phillips, L.H., Brodaty, H., & Rendell, P.G. (2008). Recognition of disgust is selectively preserved in Alzheimer’s disease. Neuropsychologia, 46, 13631370.
Hohol, M.J., Orav, E.J., & Weiner, H.L. (1995). Disease steps in multiple sclerosis: A simple approach to evaluate disease progression. Neurology, 45, 251255.
Just, M.A., Cherkassky, V.L., Keller, T.A., Kana, R.K., & Minshew, N.J. (2007). Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex, 17, 951961.
Kaland, N., Callesen, K., Moller-Nielsen, A., Mortensen, E.L., & Smith, L. (2008). Performance of children and adolescents with Asperger syndrome or high functioning autism on advanced theory of mind tasks. Journal of Autism and Developmental Disorders, 38, 11121123.
Mohr, D.C., Goodkin, D.E., Likosky, W., Beutler, L., Gatto, N., & Langan, M.K. (1997). Identification of Beck Depression Inventory items related to multiple sclerosis. Journal of Behavioral Medicine, 20, 407414.
Nordahl, C.W., Ranganath, C., Yonelinas, A.P., DeCarli, C., Fletcher, E., & Jagust, W.J. (2006). White matter changes compromise prefrontal cortex function in healthy elderly individuals. Journal of Cognitive Neuroscience, 18, 418429.
Phillips, L.H., Channon, S., Tunstall, M., Hedenstrom, A., & Lyons, K. (2008). The role of working memory in decoding emotions. Emotion, 8, 184191.
Phillips, L.H., MacLean, R.D.J., & Allen, R. (2002). Age and the understanding of emotions: Neuropsychological and sociocognitive perspectives. Journal of Gerontology: Psychological Sciences, 57, 526530.
Ruffman, T., Henry, J.D., Livingstone, V., & Phillips, L.H. (2008). A meta-analytic review of emotion recognition and aging: Implications for neuropsychological models of aging. Neuroscience and Biobehavioral Reviews, 32, 863–881.
Samson, D., Apperly, I.A., Kathirgamanathan, U., & Humphreys, G.W. (2005). Seeing it my way: A case of a selective deficit in inhibiting self-perspective. Brain, 128, 11021111.
Smith, A. (1982). Symbol Digit Modalities Test (SDMT) Manual (Revised). Los Angeles: Western Psychological Services.
Spell, L.A. & Frank, E. (2000). Recognition of nonverbal communication of affect following traumatic brain injury. Journal of Nonverbal Behavior, 24, 285300.
Sprengelmeyer, R., Rausch, M., Eysel, U.T., & Przuntek, H. (1998). Neural structures associated with recognition of facial expressions of basic emotions. Proceedings of the Royal Society of London B: Biological Sciences, 265, 19271931.
Stuss, D.T. & Gow, C.A. (1992). “Frontal dysfunction” after traumatic brain injury. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 5, 272282.
Suzuki, A., Hoshino, T., Shigemasu, K., & Kawamura, M. (2006). Disgust-specific impairment of facial expression recognition in Parkinson’s disease. Brain, 129, 707717.
Tager-Flusberg, H. (2001). The theory of mind hypothesis in autism. In Burack, J., Charman, T., Yirmiya, N. & Zelano, P.R. (Eds.), Development in autism: Perspectives from theory and research (pp. 173193). Hillsdale, NJ: Erlbaum.
Tedeschi, G., Lavorgna, L., Russo, P., Prinster, A., Dinacci, D., Savettieri, G., Quattrone, A., Livrea, P., Messina, C., Reggio, A., Bresciamorra, V., Orefice, G., Paciello, M., Brunetti, A., Coniglio, G., Bonavita, S., Di Costanzo, A., Bellacosa, A., Valentino, P., Quarantelli, M., Patti, F., Salemi, G., Cammarata, E., Simone, I.L., Salvatore, M., Bonavita, V., & Alfano, B. (2005). Brain atrophy and lesion load in a large population of patients with multiple sclerosis. Neurology, 65, 280285.
Thomas, C., Moya, L., Avidan, G., Humphreys, K., Jung, K.J., Peterson, M.A., & Behrmann, M. (2008). Reduction in white matter connectivity revealed by diffusion tensor imaging, may account for age-related changes in face perception. Journal of Cognitive Neuroscience, 20, 268284.
Tribe, K.L., Longley, W.A., Fulcher, G., Faine, R.J., Blagus, L., Pearce, G., Hope, A.D., & Henderson, E.M. (2006). Living a life with multiple sclerosis in New South Wales, Australia, at the beginning of the 21st century: Impact of mobility disability. International Journal of MS Care, 8, 1930.
Yesavage, J.A., Brink, T.L., Rose, T.L., Lum, O., Huang, V., Adey, M., & Leirer, V.O. (1983). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17, 3749.
Zachary, R. (1986). Shipley Institute of Living Scale–Revised. Los Angeles: Western Psychological Services.

Keywords

Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis

  • JULIE D. HENRY (a1), LOUISE H. PHILLIPS (a2), WILLIAM W. BEATTY (a3), SKYE MCDONALD (a1), WENDY A. LONGLEY (a4), AMY JOSCELYNE (a1) and PETER G. RENDELL (a5)...

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