Skip to main content Accessibility help
×
Home

The anterior temporal lobes and the functional architecture of semantic memory

  • W. KYLE SIMMONS (a1) and ALEX MARTIN (a1)

Abstract

Recently, three accounts have emerged on the role of the anterior temporal lobes (ATLs) in semantic memory. One account claims that the ATLs are domain-general semantic hubs, another claims that they underlie knowledge of unique entities specifically, and yet another account claims that they support social conceptual knowledge generally. Here, we review neuropsychological and neuroimaging studies that bear on these three accounts and offer suggestions for future research to elucidate the roles of the ATLs in semantic memory. (JINS, 2009, 15, 645–649.)

Copyright

Corresponding author

*Correspondence and reprint requests to: W. Kyle Simmons, Ph.D, Laboratory of Brain & Cognition, National Institute of Mental Health, Building 10, Room 4C-104, MSC 1366, Bethesda, MD 20892-1366. E-mail: simmonswkyle@mail.nih.gov

References

Hide All
Brambati, S.M., Rankin, K.P., Narvid, J., Seeley, W.W., Dean, D., Rosen, H.J., et al. (2009). Atrophy progression in semantic dementia with asymmetric temporal involvement: A tensor-based morphometry study. Neurobiology of Aging, 30, 103–111.
Castelli, F., Happe, F., Frith, U., & Frith, C. (2000). Movement and mind: A functional imaging study of perception and interpretation of complex intentional movement patterns. Neuroimage, 12, 314–25.
Crinion, J.T., Lambon Ralph, M.A., Warburton, E.A., Howard, D., & Wise, R.J.S. (2003). Temporal lobe regions engaged during normal speech comprehension. Brain, 126, 1193–1201.
Damasio, H., Tranel, D., Grabowski, T., Adolphs, R., & Damasio, A. (2004). Neural systems behind word and concept retrieval. Cognition 92, 179–229.
Davis, M.H., & Johnsrude, I.S. (2003). Hierarchical processing in spoken language comprehension. Journal of Neuroscience, 23, 3423–3431.
Devlin, J.T., Russell, R.P., Davis, M.H., Price, C.J., Wilson, J., Moss, H.E., et al. (2000). Susceptibility-induced loss of signal: Comparing PET and fMRI on a semantic task. Neuroimage, 11, 589–600.
Drane, D.L., Ojemann, G.A., Aylward, E., Ojemann, J.G., Johnson, L.C., Silbergeld, D.L., et al. (2008). Category-specific naming and recognition deficits in temporal lobe epilepsy surgical patients. Neuropsychologia, 46, 1242–1255.
Frith, C.D. (2007). The social brain? Philosophical Transactions of the Royal Society London: Series B, Biological Sciences, 362, 671–678.
Fukatsu, R., Fujii, T., Tsukiura, T., Yamadori, A., & Otsuki, T. (1999). Proper name anomia after left temporal lobectomy: A patient study. Neurology, 52, 1096–1099.
Glosser, G., Salvucci, A.E., & Chiaravalloti, N.D. (2003). Naming and recognizing famous faces in temporal lobe epilepsy. Neurology, 61, 81–86.
Gorno-Tempini, M.L., Price, C.J., Josephs, O., Vandenberghe, R., Cappa, S.F., Kapur, N., et al. (1998). The neural systems sustaining face and proper-name processing. Brain, 121, 2103–2118.
Grabowski, T.J., Damasio, H., Tranel, D., Ponto, L.L., Hichwa, R.D., & Damasio, A.R. (2001). A role for left temporal pole in the retrieval of words for unique entities. Human Brain Mapping, 13, 199–212.
Grezes, J., Frith, C., & Passingham, R.E. (2004). Brain mechanisms for inferring deceit in the actions of others. Journal of Neuroscience, 24, 5500–5505.
Grill-Spector, K. (2003). The neural basis of object perception. Current Opinion in Neurobiology, 13, 159–166.
Kriegeskorte, N., Formisano, E., Sorger, B., & Goebel, R. (2007). Individual faces elicit distinct response patterns in human anterior temporal cortex. Proceedings of the National Academy of Sciences of the United States of America, 104, 20600–20605.
Lambon Ralph, M.A., & Patterson, K. (2008). Generalization and differentiation in semantic memory: Insights from semantic dementia. Annals of the New York Academy of Science, 1124, 61–76.
Leveroni, C.L., Seidenberg, M., Mayer, A.R., Mead, L.A., Binder, J.R., & Rao, S.M. (2000). Neural systems underlying the recognition of familiar and newly learned faces. Journal of Neuroscience, 20, 878–886.
Levy, D.A., Bayley, P.J, & Squire, L.R. (2004). The anatomy of semantic knowledge: Medial vs. lateral temporal lobe. Proceedings of the National Academy of Sciences of the United States of America, 101, 6710–6715.
Martin, A. (2007). The representation of object concepts in the brain. Annual Review of Psychology, 58, 25–45.
McClelland, J.L., & Rogers, T.T. (2003). The parallel distributed processing approach to semantic cognition. Nature Reviews Neuroscience, 4, 310–322.
Moll, J., de Oliveira-Souza, R., Eslinger, P.J., Bramati, I.E., Mourao-Miranda, J., Andreiuolo, P.A., et al. (2002). The neural correlates of moral sensitivity: A functional magnetic resonance imaging investigation of basic and moral emotions. Journal of Neuroscience, 22, 2730–2736.
Mur, M., Bandettini, P.A., & Kriegeskorte, N. (2009). Revealing representational content with pattern-information fMRI–an introductory guide. Social, Cognitive, and Affective Neuroscience, 4, 101–109.
Nakamura, K., Kawashima, R., Sato, N., Nakamura, A., Sugiura, M., Kato, T., et al. (2000). Functional delineation of the human occipito-temporal areas related to f ace and scene processing. A PET study. Brain, 123, 1903–1912.
Noppeney, U., Patterson, K., Tyler, L.K., Moss, H., Stamatakis, E.A., Bright, P., et al. (2007). Temporal lobe lesions and semantic impairment: A comparison of herpes simplex virus encephalitis and semantic dementia. Brain, 130, 1138–1147.
Olson, I.R., Plotzker, A., & Ezzyat, Y. (2007). The enigmatic temporal pole: A review of findings on social and emotional processing. Brain 130, 1718–1731.
Patterson, K., Nestor, P.J., & Rogers, T.T. (2007). Where do you know what you know? The representation of semantic knowledge in the human brain. Nature Reviews Neuroscience, 8, 976–987.
Pobric, G., Jefferies, E., & Lambon-Ralph, M.A. (2007). Anterior temporal lobes mediate semantic representation: Mimicking semantic dementia by using rTMS in normal participants. Proceedings of the National Academy of Sciences of the United States of America, 104, 20137–20141.
Pourtois, G., Schwartz, S., Segheir, M.L., Lazeyras, F., & Vuilluemier, P. (2005). View-independent coding of face identity in frontal and temporal cortices is modulated by familiarity: An event-related fMRI study. Neuroimage, 24, 1214–1224.
Powell, H.W., Parker, G.J., Alexander, D.C., Symms, M.R., Boulby, P.A., Wheeler-Kingshott, C.A., et al. (2007). Abnormalities of language networks in temporal lobe epilepsy. Neuroimage, 36, 209–221.
Rogers, T.T., Hocking, J., Noppeney, U., Mechelli, A., Gorno-Tempini, M.L., Patterson, K., et al. (2006). Anterior temporal cortex and semantic memory: Reconciling findings from neuropsychology and functional imaging. Cognitive, Affective & Behavioral Neuroscience, 6, 201–213.
Rogers, T.T., Lambon Ralph, M.A., Garrard, P., Bozeat, S., McClelland, J.L., Hodges, J.R., et al. (2004). Structure and deterioration of semantic memory: A neuropsychological and computational investigation. Psychological Review, 111, 205–235.
Rogers, T.T., & McClelland, J.L. (2004). Semantic cognition: A parallel distributed processing approach. Cambridge, MA: MIT Press.
Rotshtein, P., Henson, R.N., Treves, A., Driver, J., & Dolan, R.J. (2005). Morphing Marilyn into Maggie dissociates physical and identity face representations in the brain. Nature Neuroscience, 8, 107–113.
Rounis, E., Stephan, K.E., Lee, L., Siebner, H.R., Pesenti, A., Friston, K., et al. (2006). Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task. Journal of Neuroscience, 26, 9629–9638.
Schultz, R.T., Grelotti, D.J., Klin, A., Kleinman, J., Van der Gaag, C., Marois, R., et al. (2003). The role of the fusiform face area in social cognition: Implications for the pathobiology of autism. Philosophical Transactions of the Royal Society London: Series B, Biological Sciences, 358, 415–427.
Sergent, J., & Signoret, J.L. (1992). Functional and anatomical decomposition of face processing: Evidence from prosopagnosia and PET study of normal subjects. Philosophical Transactions of the Royal Society London: Series B, Biological Sciences, 335, 55–62.
Simmons, W.K., Reddish, M., Bellgowan, P.F.S., & Martin, A. (in press). The selectivity and functional connectivity of the anterior temporal lobes. Cerebral Cortex.
Sugiura, M., Kawashima, R., Nakamura, K., Sato, N., Nakamura, A., Kato, T., et al. (2001). Activation reduction in anterior temporal cortices during repeated recognition of faces and personal acquaintances. Neuroimage, 13, 877–890.
Thompson-Schill, S.L. (2003). Neuroimaging studies of semantic memory: Inferring “how” from “where.” Neuropsychologia, 41, 280–292.
Tranel, D. (2006). Impaired naming of unique landmarks is associated with left temporal polar damage. Neuropsychology 20, 1–10.
Tsukiura, T., Namiki, M., Fujii, T., & Iijima, T. (2003). Time-dependent neural activations related to recognition of people’s names in emotional and neutral face-name associative learning: An fMRI study. Neuroimage, 20, 784–794.
Tsukiura, T., Toshikatsu, F., Fukatsu, R., Otsuki, T., Okuda, J., Umetsu, A., et al. (2003). Neural basis of the retrieval of people’s names: Evidence from brain-damaged patients and fMRI. Journal of Cognitive Neuroscience, 14, 922–937.
Tyler, L.K., Stamatakis, E.A., Bright, P., Acres, K., Abdallah, S., Rodd, J.M., et al. (2004). Processing objects at different levels of specificity. Journal of Cognitive Neuroscience, 16, 351–362.
Vandenberghe, R., Price, C., Wise, R., Josephs, O., & Frackowiak, R.S.J. (1996). Functional anatomy of a common semantic system for words and pictures. Nature, 383, 254–256.
Vandenberghe, R., Nobre, A.C., & Price, C.J. (2002). The response of left temporal cortex to sentences. Journal of Cognitive Neuroscience, 14, 550–560.
Williams, G.B., Nestor, P.J., & Hodges, J.R. (2005). Neural correlates of semantic and behavioural deficits in frontotemporal dementia. Neuroimage 24, 1042–1051.
Zahn, R., Moll, J., Iyengar, V., Huey, E.D., Tierney, M., Krueger, F., et al. (2009). Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism. Brain. 132, 604–616.
Zahn, R., Moll, J., Krueger, F., Huey, E.D., Garrido, G., & Grafman, J. (2007). Social concepts are represented in the superior anterior temporal cortex. Proceedings of the National Academy of Sciences of the United States of America, 104, 6430–6435.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed