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Performance of the NINDS-CSN 5-Minute Protocol in a National Population-Based Sample

Published online by Cambridge University Press:  27 August 2014

Richard E. Kennedy*
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
Virginia G. Wadley
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
Leslie A. McClure
Affiliation:
Department of Biostatistics, University of Alabama Birmingham, Birmingham, Alabama
Abraham J. Letter
Affiliation:
WL Gore and Associates, Flagstaff, Arizona
Frederick W. Unverzagt
Affiliation:
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana
Michael Crowe
Affiliation:
Department of Psychology, University of Alabama Birmingham, Birmingham, Alabama
David Nyenhius
Affiliation:
Hauenstein Neuroscience Center, Mercy Health Saint Mary’s, Grand Rapids, Michigan
Brendan J. Kelley
Affiliation:
Department of Neurology, Ohio State University, Columbus, Ohio
Bhumika Kana
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
Janice Marceaux
Affiliation:
Department of Psychology, University of Alabama Birmingham, Birmingham, Alabama
Manjula Kurella Tamura
Affiliation:
Department of Medicine, Stanford University, Stanford, California
Virginia Howard
Affiliation:
Department of Epidemiology, University of Alabama Birmingham, Birmingham, Alabama
George Howard
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
*
Correspondence and reprint requests to: Richard E. Kennedy, Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, 933 19th Street South, CH19-218R, Birmingham, AL. E-mail: rekenned@uab.edu

Abstract

In 2006, the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) Vascular Cognitive Impairment Harmonization Standards recommended a 5-Minute Protocol as a brief screening instrument for vascular cognitive impairment (VCI). We report demographically adjusted norms for the 5-Minute Protocol and its relation to other measures of cognitive function and cerebrovascular risk factors. We performed a cross-sectional analysis of 7199 stroke-free adults in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study on the NINDS-CSN 5-Minute Protocol score. Total scores on the 5-Minute Protocol were inversely correlated with age and positively correlated with years of education, and performance on the Six-Item Screener, Word List Learning, and Animal Fluency (all p-values <.001). Higher cerebrovascular risk on the Framingham Stroke Risk Profile (FSRP) was associated with lower total 5-Minute Protocol scores (p <.001). The 5-Minute Protocol also differentiated between participants with and without confirmed stroke and with and without stroke symptom histories (p <.001). The NINDS-CSN 5-Minute Protocol is a brief, easily administered screening measure that is sensitive to cerebrovascular risk and offers a valid method of screening for cognitive impairment in populations at risk for VCI. (JINS, 2014, 20, 1–12)

Type
Research Articles
Copyright
Copyright © The International Neuropsychological Society 2014 

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