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Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk

  • Marlena C. Kruger (a1), Pamela R. von Hurst (a2), Christine L. Booth (a1), Barbara Kuhn-Sherlock (a3), Joanne M. Todd (a4) and Linda M. Schollum (a3)...

Abstract

Acute doses of Ca rapidly increase serum Ca and reduce bone resorption concomitant with a reduction in serum parathyroid hormone (PTH) levels. The physiological response to a dose of Ca in milk and to a Ca salt may be different. The present study investigated Ca absorption patterns with increasing levels of fortification in milk, and the response to one dose of a Ca salt. A group of twenty-eight Asian women aged 20–45 years volunteered to attend the laboratory over several weeks. The fasted volunteers were randomised to one of three experimental drinks: 200 ml skimmed milk containing 250, 500 or 1000 mg Ca. A subgroup of seven volunteers also received a calcium gluconate/carbonate salt containing 1000 mg Ca in 200 ml water. Serial blood samples and urine were collected for 5 h from baseline. Different doses of Ca in milk resulted in a graded response in serum corrected Ca, PTH and C-telopeptide of type I collagen (CTx) but not ionised Ca. Serum Ca increased in response to all milk drinks and from 2 to 5 h the blood Ca levels were significantly different for the 250 and 1000 mg doses, as was the integrated response between the loads. The PTH response to the two higher doses was significantly more than following the 250 mg dose. The integrated response for CTx and urinary Ca between all three doses of Ca in milk was significantly different. A dose of Ca salt elicited a more immediate response reaching a plateau faster, and declining faster to baseline. Fortified milk is a safe matrix for delivering larger doses of Ca.

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Copyright

The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution license .

Corresponding author

* Corresponding author: Dr Marlena C. Kruger, email m.c.kruger@massey.ac.nz

References

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1. Guillemant, J & Guillemant, S (1993) Comparison of the suppressive effect of two doses (500 mg vs 1500 mg) of oral calcium and parathyroid hormone secretion and on urinary cyclic AMP. Calcif Tissue Int 53, 304306.
2. Karp, HJ, Ketola, ME & Lamberg-Allardt (2009) Acute effects of calcium carbonate, calcium citrate and potassium citrate on markers of calcium and bone metabolism in young women. Br J Nutr 102, 13411347.
3. Sadideen, H & Swaminathan, R (2004) Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects: an overnight study. Eur J Clin Nutr 58, 16611665.
4. Yang, R-S, Liu, T-K & Tsai, K-S (1994) The acute metabolic effects of oral tricalcium phosphate and calcium carbonate. Calcif Tissue Int 55, 335341.
5. Heaney, RP, Weaver, CM, Fitzsimmons, ML, et al. (1990) Calcium absorptive consistency. J Bone Miner Res 5, 11391142.
6. Heaney, RP, Weaver, CM & Fitzsimmons, ML (1990) Influence of calcium load on absorption fraction. J Bone Miner Res 5, 11351138.
7. Heaney, RP, Berner, B & Louie-Helm, J (2000) Dosing regimen for calcium supplementation. J Bone Miner Res 15, 2291.
8. Heaney, RP, Saville, PD & Recker, RR (1975) Calcium absorption as a function of calcium intake. J Lab Clin Med 85, 881890.
9. Harvey, JA, Zobitz, MM & Pak, CYC (1988) Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate. J Bone Miner Res 3, 253258.
10. Käkkäinem, MUM, Lamberg-Allardt, CJE, Ahonen, S, et al. (2001) Does it make a difference how and when you take your calcium? The acute effects of calcium and bone metabolism. Am J Clin Nutr 74, 335342.
11. Green, JH, Booth, C & Bunning, R (2003) Postprandial metabolic responses to milk enriched with milk calcium are different from responses to milk enriched with calcium carbonate. Asia Pac J Clin Nutr 12, 109119.
12. Recker, RR & Heaney, RP (1985) The effect of milk supplements on calcium metabolism, bone metabolism and calcium balance. Am J Clin Nutr 41, 254263.
13. Reid, IR, Bolland, MJ & Grey, A (2010) Does calcium supplementation increase cardiovascular risk? Clin Endocrinol (Oxf) 73, 689695.
14. Kärkkäinem, MUM, Wiersma, JW & Lamberg-Allardt, CJE (1997) Postprandial parathyroid hormone response to four calcium-rich foodstuffs. Am J Clin Nutr 65, 17261730.
15. Green, JH, Booth, C & Bunning, R (2003) Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption. Eur J Clin Nutr 57, 6168.
16. Heaney, RP, McCarron, DA, Dawson-Hughes, B, et al. (1999) Dietary changes favourably affect bone remodelling in older adults. J Am Diet Assoc 99, 12281233.
17. Kruger, MC, Schollum, LM, Kuhn-Sherlock, B, et al. (2006) Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women. Nutrition 22, 11201128.
18. Kruger, MC, Schollum, LM, Kuhn-Sherlock, B, et al. (2010) The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia. Bone 46, 759767.
19. Maunsell, Z, Wright, DJ & Rainbow, SJ (2005) Routine isotope-dilution liquid chromatography–tandem mass spectrometry assay for simultaneous measurement of 25-hydroxy metabolites of vitamins D2 and D3 . Clin Chem 51, 16831690.
20. Horowitz, M, Morris, HA, Hartley, TF, et al. (1987) The effect of an oral calcium load on plasma ionized calcium and parathyroid hormone concentrations in osteoporotic postmenopausal women. Calcif Tissue Int 40, 133136.
21. Heaney, RP, Dowell, MS, Bierman, J, et al. (2001) Absorbability and cost effectiveness in calcium supplementation. J Am Coll Nutr 20, 239246.
22. Reid, IR, Hannan, SF, Schooler, BA, et al. (1986) The acute biochemical effects of four proprietary calcium preparations. Aust NZ J Med 16, 193197.
23. Talbot, JR, Guardo, P, Seccia, S, et al. (1999) Calcium bioavailability and parathyroid hormone acute changes after oral intake of dairy and nondairy products in healthy volunteers. Osteoporos Int 10, 137142.
24. Zikán, V, Haas, T & Stepan, JJ (2001) Acute effects in healthy women of oral calcium on the calcium–parathyroid axis and bone resorption as assessed by serum β-CrossLaps. Calcif Tissue Int 68, 352357.
25. Nickel, KP, Martin, BR, Smith, DL, et al. (1996) Calcium bioavailability from bovine milk and dairy products in premenopausal women using intrinsic and extrinsic labelling techniques. J Nutr 126, 14061411.
26. Martini, L & Wood, RJ (2002) Relative bioavailability of calcium-rich dietary sources in the elderly. Am J Clin Nutr 76, 13451350.
27. López-Huertas, E, Teacher, B, Boza, JJ, et al. (2006) Absorption of calcium from milks enriched with fructo-oligosaccharides, caseinophosphopeptides, tricalcium phosphate, and milk solids. Am J Clin Nutr 83, 310316.
28. Guillemant, J, Le, H-T, Maria, A, et al. (2000) Acute effects of oral calcium load on parathyroid function and on bone resorption in young men. Am J Nephrology 20, 4852.
29. Bonewald, LF (2011) The amazing osteocyte. J Bone Miner Res 26, 229238.
30. Reid, IR, Bolland, MJ, Avenell, A, et al. (2011) Cardiovascular effects of calcium supplementation. Osteoporos Int 22, 16491658.
31. Bolland, MJ, Barber, PA, Doughty, RN, et al. (2008) Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 336, 262266.
32. Bolland, MJ, Avenell, A, Baron, JA, et al. (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 341, c3691.

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Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk

  • Marlena C. Kruger (a1), Pamela R. von Hurst (a2), Christine L. Booth (a1), Barbara Kuhn-Sherlock (a3), Joanne M. Todd (a4) and Linda M. Schollum (a3)...

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