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Acute hormonal response to glucose, lipids and arginine infusion in overweight cats

  • Lucile J. M. Martin (a1), Thomas A. Lutz (a2), Caroline Daumas (a1), Philippe Bleis (a1), Patrick Nguyen (a1), Vincent Biourge (a3) and Henri J. W. Dumon (a1)...

Abstract

In cats, the incidence of obesity and diabetes is increasing, and little is known about specific aspects of the endocrine control of food intake in this species. Recent data suggest that ghrelin has an important role in the control of insulin secretion and vice versa, but this role has never been demonstrated in cats. Here we aimed to improve our understanding about the relationship between insulin, amylin and ghrelin secretion in response to a nutrient load in overweight cats. After a 16 h fast, weekly, six overweight male cats underwent randomly one of the four testing sessions: saline, glucose, arginine and TAG. All solutions were isoenergetic and isovolumic, and were injected intravenously as a bolus. Glucose, insulin, acylated ghrelin (AG), amylin and prolactin were assayed in plasma before and 10, 20, 40, 60, 80 and 100 min after the nutrient load. A linear mixed-effects model was used to assess the effect of bolus and time on the parameters. A parenteral bolus of glucose or arginine increased insulin and ghrelin concentrations in cats. Except for with the TAG bolus, no suppression of ghrelin was observed. The absence of AG suppression after the intravenous load of arginine and glucose may suggest: (1) that some nutrients do not promote satiation in overweight cats; or that (2) AG may be involved in non-homeostatic consumption mechanisms. However, the role of ghrelin in food reward remains to be assessed in cats.

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Copyright

The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution license .

Corresponding author

* Corresponding author: Dr Lucile Martin, fax + 33 240 687 746, email lucile.martin@oniris-nantes.fr

References

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Keywords

Acute hormonal response to glucose, lipids and arginine infusion in overweight cats

  • Lucile J. M. Martin (a1), Thomas A. Lutz (a2), Caroline Daumas (a1), Philippe Bleis (a1), Patrick Nguyen (a1), Vincent Biourge (a3) and Henri J. W. Dumon (a1)...

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