In this article, the analyses of the natural frequency and buckling of orthotopic nanoplates, such as single-layered graphene sheets, resting on Pasternak's elastic foundations with various boundary conditions are presented. New functions for midplane displacements are suggested to satisfy the different boundary conditions. These functions are examined by comparing their results with the results obtained by using the functions suggested by Reddy (Reddy JN. Mechanics of Composite Materials and Structures: Theory and Analysis. Boca Raton, FL: CRC Press; 1997). Moreover, these functions are very simple comparing with Reddy's functions, leading to ease of calculations. The equations of motion of the nonlocal model are derived using the sinusoidal shear deformation plate theory (SPT) in conjunction with the nonlocal elasticity theory. The present SPT are compared with other plate theories. Explicit solution for buckling loads and vibration are obtained for single-layered graphene sheets with isotropic and orthotropic properties; and under biaxial loads. The formulation and the method of the solution are firstly validated by executing the comparison studies for the isotropic nanoplates with the results being in literature. Then, the influences of nonlocal parameter and the other parameters on the buckling and vibration frequencies are investigated.