Skip to main content Accessibility help
×
Home

Volumetric analysis of vocal fold atrophy via magnetic resonance imaging

  • S Saint-Victor (a1), E Barbarite (a1), C Sidani (a2), R Bhatia (a2) and D E Rosow (a1)...

Abstract

Objective

To quantitatively test the hypothesis that older patients have increased thyroarytenoid muscle atrophy by comparing thyroarytenoid muscle volumes across different age groups.

Methods

A retrospective chart review was conducted. The study included 111 patients with no history of laryngeal pathology. Two investigators reviewed magnetic resonance imaging studies of these patients and manually traced the thyroarytenoid muscles on multiple slices bilaterally. Thyroarytenoid muscle volumes were then computed using imaging analysis software. Patients were stratified into three age groups (18–50 years, 51–64 years, and 65 years or older) for comparison.

Results

Intra- and inter-rater reliabilities were excellent for all measurements (intraclass correlation co-efficient > 0.90). There was no statistically significant difference in the mean volumes of left and right thyroarytenoid muscles in all age and gender groups.

Conclusion

Given the lack of statistically significant difference in thyroarytenoid muscle volume between age groups on magnetic resonance imaging, the prevailing assumption that age-related thyroarytenoid muscle atrophy contributes to presbyphonia should be re-examined.

Copyright

Corresponding author

Author for correspondence: Dr David E Rosow, 1120 NW 14th Street, 5th Floor, Miami, FL 33136, USA E-mail: DRosow@med.miami.edu Fax: +1 305 243 2009

Footnotes

Hide All

Dr D E Rosow takes responsibility for the integrity of the content of the paper

Presented at the American Laryngological Association Annual Meeting, 26–28 April 2017, San Diego, California, USA.

Footnotes

References

Hide All
1Roy, N, Stemple, J, Merrill, RM, Thomas, L. Epidemiology of voice disorders in the elderly: preliminary findings. Laryngoscope 2007;117:628–33
2Von Leden, H, Alessi, DM. The aging voice. In: Benninger, MS, Jacobson, BJ, Johnson, AF, eds. Vocal Arts Medicine: The Care and Prevention of Professional Voice Disorders. New York: Thieme Medical Publishers, 1994;269–80
3Martins, RH, Pessin, AB, Nassib, DJ, Branco, A, Rodrigues, SA, Matheus, SM. Aging voice and the laryngeal muscle atrophy. Laryngoscope 2015;125:2518–21
4Jang, YC, Van Remmen, H. Age-associated alternations of neuromuscular junction. Exp Gerontol 2011;46:193–8
5Nair, KS. Aging muscle. Am J Clin Nutr 2005;81:953–63
6Kirkeby, S, Garbarsch, C. Aging affects different human muscles in various ways. An imaging analysis of histomorphometric characteristics of fiber types in human masseter and vastus lateralis muscles from young adults and the very old. Histol Histopathol 2000;13:6171
7Yamauchi, A, Imagawa, H, Sakakaibara, K, Yokonishi, H, Ueha, R, Nito, T et al. Vocal fold atrophy in a Japanese tertiary medical institute: status quo of the most aged country. J Voice 2014;28:231–6
8Kwong, Y, Boddu, S, Shah, J. Radiology of vocal cord palsy. Clin Radiol 2012;67:1108–14
9Konomi, U, Tokashiki, R, Hiramatsu, H, Kumada, M. Diagnosis and management of unilateral thyroarytenoid muscle palsy. Eur Arch Otorhinolaryngol 2016;273:3803–11
10Romo, LV, Curtin, HD. Atrophy of the posterior cricoarytenoid muscle as an indicator of recurrent laryngeal nerve palsy. AJNR Am J Neuroradiol 1999;20:467–71
11Ziade, G, Semaan, S, Fakhri, G, El Natout, T, Hamdan, AL. Thyroarytenoid muscle uptake and attenuation in PET/CT in elderly. Eur Arch Otorhinolaryngol 2016;273:4385–9
12Huang, BY, Solle, M, Weissler, MC. Larynx: anatomic imaging for diagnosis and management. Otolaryngol Clin North Am 2012;45:1325–61
13Ziade, G, Semaan, S, Ghulmiyyah, J, Kasti, M, Handan, AL. Structural and anatomic laryngeal measurements in geriatric populations using MRI. J Voice 2017;31:359–62
14Thomas, LB, Harrison, AL, Stemple, JC. Aging thyroarytenoid and limb skeletal muscle: lessons in contrast. J Voice 2008;22:430–50
15The Older Population: 2010 (United States Census Bureau Brief). In: https://www.census.gov/prod/cen2010/briefs/c2010br-09.pdf [31 March 2017]
16Bearden, SE. Effect of aging on the structure and function of skeletal muscle microvascular networks. Microcirculation 2006;13:279–88
17Kendall, K. Presbyphonia: a review. Curr Opin Otolaryngol Head Neck Surg 2007;15:137–40
18Malmgren, LT, Fisher, PJ, Bookman, LM, Uno, T. Age-related changes in muscle fiber types in the human thyroarytenoid muscle: an immunohistochemical and stereological study using confocal laser scanning microscopy. Otolaryngol Head Neck Surg 1999;121:441–51
19Nishida, N, Taguchi, A, Motoyoshi, K, Hyodo, M, Gyo, K, Desaki, J. Age-related changes in rat intrinsic laryngeal muscles: analysis of muscle fibers, muscle fiber proteins, and subneural apparatuses. Eur Arch Otorhinolaryngol 2013;270:975–84
20Branco, A, Rodrigues, SA, Fabro, AT, Fonseca-Alves, CE, Martins, RH. Hyaluronic acid behavior in the lamina propria of the larynx with advancing age. Otolaryngol Head Neck Surg 2014;151:652–6
21Rosen, CA, Gartner-Schmidt, J, Casiano, R, Anderson, TD, Johnson, F, Remacle, M et al. Vocal fold augmentation with calcium hydroxylapatite: twelve-month report. Laryngoscope 2009;119:1033–41
22Lisi, C, Hawkshaw, MJ, Sataloff, RT. Viscosity of materials for laryngeal injection: a review of current knowledge and clinical implications. J Voice 2012;27:119–23
23Hsiung, MW, Woo, P, Minasian, A, Schaefer Mojica, J. Fat augmentation for glottic insufficiency. Laryngoscope 2000;110:1026–33
24Chan, KM, Li, RH, Chapman, JW, Trac, EM, Kobler, JB, Zeitels, SM et al. Functionalizable hydrogel microparticles of tunable size and stiffness for soft-tissue filler application. Acta Biomater 2014;10:2563–73
25Hirano, S, Nagai, H, Tateya, I, Tateya, T, Ford, CN, Bless, DM. Regeneration of aged vocal folds with basic fibroblast growth factor in a rat model: a preliminary report. Ann Otol Rhinol Laryngol 2005;114:304–8
26Ohno, S, Hirano, S, Yasumoto, A, Ikeda, H, Takebayashi, S, Miura, M. Outcome of regenerative therapy for age-related vocal fold atrophy with basic fibroblast growth factor. Laryngoscope 2016;126:1844–8

Keywords

Related content

Powered by UNSILO

Volumetric analysis of vocal fold atrophy via magnetic resonance imaging

  • S Saint-Victor (a1), E Barbarite (a1), C Sidani (a2), R Bhatia (a2) and D E Rosow (a1)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.