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Regeneration of the tympanic membrane using fibroblast growth factor-2

Published online by Cambridge University Press:  18 July 2018

Z-C Lou ,
Z-H Lou  and
J Xiao
Z-C Lou*
Affiliation:
Department of Otorhinolaryngology, Affiliated YiWu Hospital of Wenzhou Medical University, Zhejiang, China
Z-H Lou
Affiliation:
Department of Clinical Medicine, Xinxiang Medical University, Xinxiang City, China
J Xiao
Affiliation:
Molecular Pharmacology Research Center, School of Pharmacy, Zhejiang Provincial Key Laboratory of Biotechnology Pharmaceutical Engineering, Wenzhou Medical University, Zhejiang, China
*
Author for correspondence: Dr Zheng-Cai Lou, Department of Otorhinolaryngology, Affiliated YiWu Hospital of Wenzhou Medical University, 699 Jiangdong Road, YiWu, Zhejiang 322000, China Fax: +86 0579 520 9678 E-mail: louzhengcai@163.com.
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Abstract

Objective

A systematic review was conducted to investigate the effectiveness of fibroblast growth factor-2 on the regeneration of tympanic membrane perforation.

Methods

The PubMed database was searched for relevant studies. Experimental studies, human randomised controlled trials, prospective single-arm studies and retrospective studies reporting acute and chronic tympanic membrane perforations in relation to two healing outcomes (success rate and closure time), were selected.

Results

All 11 clinical studies investigating the effect of fibroblast growth factor-2 on traumatic tympanic membrane perforations in humans reported a success rate of 89.3–100 per cent, with a closure time of around 2 weeks. Three studies of fibroblast growth factor-2 combined with Gelfoam showed that the success rate of chronic tympanic membrane perforation was 83–98.1 per cent in the fibroblast growth factor-2 group, but 10 per cent in the gelatine sponge groups.

Conclusion

Fibroblast growth factor-2 with or without biological material patching promotes regeneration in cases of acute and chronic tympanic membrane perforation, and is safe and efficient. However, the best dosage, application time and administration pathway of fibroblast growth factor-2 are still to be elucidated.

Keywords

Tympanic MembraneRegenerationFibroblast Growth Factor 2
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 6 , June 2018 , pp. 470 - 478
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr Z-C Lou takes responsibility for the integrity of the content of the paper

References

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