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Global Epidemiology of Clostridium difficile Infection in 2010

Published online by Cambridge University Press:  02 January 2015

Dale N. Gerding*
Affiliation:
Edward Hines Jr. VA Hospital, Hines and Loyola University Chicago Stritch, School of Medicine, Chicago, Illinois
*
Research Service (151), Edward Hines Jr. VA Hospital, Building 1, Room C344, Hines, IL 60611 (dale.gerding2@va.gov)

Abstract

The past decade has been characterized by an epidemic of Clostridium difficile infection in North America and Europe that threatens to extend to the rest of the world. The epidemic is due in part to the emergence of a previously rare and now more lethal C. difficile strain variously named group BI, ribotype 027, and North American pulsed-field gel electrophoresis type 1.

Type
Supplement Article
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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References

1.McDonald, LC, Killgore, GE, Thompson, A, et al.An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005;353(23):24332441.CrossRefGoogle ScholarPubMed
2.Loo, VG, Poirier, L, Miller, MA, et al.A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353(23):24422449.CrossRefGoogle ScholarPubMed
3.Pepin, J, Valiquette, L, Alary, ME, et al.Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004;171(5):466472.CrossRefGoogle Scholar
4.Warny, M, Pepin, J, Fang, A, et al.Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 2005;366(9491):10791084.Google Scholar
5.Cheknis, AK, Sambol, SP, Davidson, DM, et al.Distribution of Clostridium difficile strains from a North American, European and Australian trial of treatment for C. difficile infections: 2005–2007. Anaerobe 2009;15(6):230233.CrossRefGoogle ScholarPubMed
6.Debast, SB, Vaessen, N, Choudry, A, Wiegers-Ligtvoet, EA, van den Berg, RJ, Kuijper, EJ. Successful combat of an outbreak due to Clostridium difficile PCR ribotype 027 and recognition of specific risk factors. Clin Microbiol Infect 2009;15(5):427434.CrossRefGoogle ScholarPubMed
7.Kuijper, EJ, Barbut, F, Brazier, JS, et al.Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. Euro Surveill 2008;13(31):18942.CrossRefGoogle ScholarPubMed
8.Hensgens, MP, Goorhuis, A, Notermans, DW, van Benthem, BH, Kuijper, EJ. Decrease of hypervirulent Clostridium difficile PCR ribotype 027 in the Netherlands. Euro Surveill 2009;14(45):19402.CrossRefGoogle ScholarPubMed
9.Goorhuis, A, Bakker, D, Corver, J, et al.Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clin Infect Dis 2008;47(9):11621170.CrossRefGoogle ScholarPubMed
10.Belmares, J, Johnson, S, Parada, JP, et al.Molecular epidemiology of Clostridium difficile over the course of 10 years in a tertiary care hospital. Clin Infect Dis 2009;49(8):11411147.CrossRefGoogle ScholarPubMed