Skip to main content Accessibility help
×
Home

Use of antipsychotics and antidepressants in patients with HIV

  • P. Muñoz-Calero, F. García Sánchez (a1), N. Rodriguez Criado (a1), R. Martín Aragón (a1), J.F. Cruz Fourcade (a1), S. Bravo Herrero (a1) and B. Sánchez Sánchez (a1)...

Abstract

Introduction

Psychological distress appears in the majority of people infected with HIV. Depression is the most important affection, the prevalence in comparison with general population arises to 37%. Psychotic symptoms in patients with HIV are a very frequent entity, in some cases, these symptoms are pre-existent in others the evolution of the infection or a medical cause related with the infection can cause its apparition. Psychosis and depression in patients with HIV have some clinical and therapeutical considerations. Antidepressants and antipsychotics have many pharmacological interactions with antiretroviral therapy.

Objectives

Review the efficacy and safety of antidepressants and antipsychotics in patients with HIV infection.

Methods

PubMed was searched for articles published between 1966 and January 1, 2015, using the search terms HIV, AIDS, depression, phycosis, antipsychotics, antidepressants, antiretrovirals. We selected randomized placebo controlled or active comparator control trials.

Results

Twelve studies for depression treatment and 2 studies for psychosis treatment in patients with HIV infection. Selective serotonin reuptake inhibitors (SSRI) especially fluoxetine and tryciclic antidepressants are effective in treating depressive symptoms in patients with HIV infection. Testosterone and stimulants have been used in patients with mild depressive symptoms, however studies with these agents had a small sample size. Haloperidol and chlorpromazine were effective for AIDS delirium, there are not controlled trials with other antipsychotics.

Conclusions

Psychiatrists must be concern about the clinical particularities of patients with HIV and depression or psychotic symptoms. The election of antidepressant or antipsychotic has to be made very carefully because of their side effects and interactions.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Copyright

Corresponding author

*Corresponding author.

Use of antipsychotics and antidepressants in patients with HIV

  • P. Muñoz-Calero, F. García Sánchez (a1), N. Rodriguez Criado (a1), R. Martín Aragón (a1), J.F. Cruz Fourcade (a1), S. Bravo Herrero (a1) and B. Sánchez Sánchez (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

Use of antipsychotics and antidepressants in patients with HIV

  • P. Muñoz-Calero, F. García Sánchez (a1), N. Rodriguez Criado (a1), R. Martín Aragón (a1), J.F. Cruz Fourcade (a1), S. Bravo Herrero (a1) and B. Sánchez Sánchez (a1)...
Submit a response

Comments

No Comments have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *