Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-24T18:18:19.826Z Has data issue: false hasContentIssue false
  • English
  • Français

Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

Published online by Cambridge University Press:  16 April 2020

J.J. Mann  and
D.M. Currier
J.J. Mann*
Affiliation:
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY10032, United States
D.M. Currier
Affiliation:
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY10032, United States
*
*Corresponding author. Tel.: +212 543 5571; fax: +212 543 6017. E-mail addresses:jjm@columbia.edu (J.J. Mann).
Get access

Abstract

Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.

Keywords

SuicideSuicidal behaviorMajor depressionEpigeneticsGeneticsEnvironmentWhole-genomeStress
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 268 - 271
Copyright
Copyright © Elsevier Masson SAS 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anguelova, M, Benkelfat, C, Turecki, GA systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003;8:646–653.CrossRefGoogle ScholarPubMed
Arborelius, L, Hawks, BW, Owens, MJ, Plotsky, PM, Nemeroff, CBIncreased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation. Psychopharmacology (Berl) 2004;176:248–255.10.1007/s00213-004-1883-xCrossRefGoogle ScholarPubMed
Barr, CS, Newman, TK, Shannon, C, Parker, C, Dvoskin, RL, Becker, MLet al.Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry 2004;55:733–738.CrossRefGoogle ScholarPubMed
Bennett, AJ, Lesch, KP, Heils, A, Long, JC, Lorenz, JG, Shoaf, SEet al.Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 2002;7:118–122.CrossRefGoogle ScholarPubMed
Bradley, RG, Binder, EB, Epstein, MP, Tang, Y, Nair, HP, Liu, Wet al.Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 2008;65:190–200.CrossRefGoogle ScholarPubMed
Brodsky, BS, Stanley, BAdverse childhood experiences and suicidal behavior. Psychiatr Clin North Am 2008;31:223–235.10.1016/j.psc.2008.02.002CrossRefGoogle ScholarPubMed
Canli, T, Lesch, KPLong story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 2007;10:1103–1109.CrossRefGoogle ScholarPubMed
Currier, D, Mann, JJStress, genes and the biology of suicidal behavior. Psychiatr Clin North Am 2008;31:247–269.CrossRefGoogle ScholarPubMed
Dunn, AJ, Swiergiel, AH, Palamarchouk, VBrain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress. Ann N Y Acad Sci 2004;1018:25–34.CrossRefGoogle ScholarPubMed
Galfalvy, H, Currier, D, Oquendo, MA, Sullivan, G, Huang, YY, Mann, JJLower CSF MHPG predicts short-term risk for suicide attempt. Int J Neuropsychopharmacol 2009;12:1327–1335.CrossRefGoogle ScholarPubMed
Haghighi, F, Bach-Mizrachi, H, Huang, YY, Arango, V, Shi, S, Dwork, AJet al.Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression. Mol Psychiatry 2008;13:813–830.CrossRefGoogle ScholarPubMed
Heim, C, Nemeroff, CBThe role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 2001;49:1023–1039.10.1016/S0006-3223(01)01157-XCrossRefGoogle ScholarPubMed
Lester, DThe concentration of neurotransmitter metabolites in the cerebrospinal fluid of suicidal individuals: a meta-analysis. Pharmacopsychiat 1995;28:45–50.CrossRefGoogle ScholarPubMed
Lopez, JF, Vazquez, DM, Chalmers, DT, Watson, SJRegulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis. Implications for the neurobiology of suicide. Ann N Y Acad Sci 1997;836:106–134.CrossRefGoogle ScholarPubMed
Mann, JJ, Currier, D, Stanley, B, Oquendo, MA, Amsel, LV, Ellis, SPCan biological tests assist prediction of suicide in mood disorders?. Int J Neuropsychopharmacol 2006;9:465–474.CrossRefGoogle ScholarPubMed
Mann, JJ, Currier, DA review of prospective studies of biologic predictors of suicidal behavior in mood disorders. Arch Suicide Res 2007;11:3–16.CrossRefGoogle ScholarPubMed
Mann, JJNeurobiology of suicidal behaviour. Nat Rev Neurosci 2003;4:819–828.CrossRefGoogle ScholarPubMed
Miller, JM, Kinnally, EL, Ogden, RT, Oquendo, MA, Mann, JJ, Parsey, RVReported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder. Synapse 2009;63:565–573.CrossRefGoogle ScholarPubMed
Oquendo, MA, Placidi, GP, Malone, KMet al.Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Arch Gen Psychiatry 2003;60:14–22.10.1001/archpsyc.60.1.14CrossRefGoogle ScholarPubMed
Owens, MJ, Nemeroff, CBPhysiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 1991;43:425–473.Google ScholarPubMed
Rinne, T, Westenberg, HG, Den Boer, JA, van den, BWSerotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients. Biol Psychiatry 2000;47:548–556.CrossRefGoogle ScholarPubMed
Roy, A, Hu, XZ, Janal, MN, Goldman, DInteraction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology 2007;32:2046–2052.CrossRefGoogle ScholarPubMed
Rujescu, D, Thalmeier, A, Moller, HJ, Bronisch, T, Giegling, IMolecular genetic findings in suicidal behavior: what is beyond the serotonergic system?. Arch Suicide Res 2007;11:17–40.CrossRefGoogle ScholarPubMed
Tyrka, AR, Price, LH, Gelernter, J, Schepker, C, Anderson, GM, Carpenter, LLInteraction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. Biol Psychiatry 2009;66:681–685.10.1016/j.biopsych.2009.05.012CrossRefGoogle ScholarPubMed
Uher, R, McGuffin, PThe moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry 2008;13:131–146.CrossRefGoogle ScholarPubMed
Voracek, M, Loibl, LMGenetics of suicide: a systematic review of twin studies. Wien Klin Wochenschr 2007;119:463–475.CrossRefGoogle ScholarPubMed
Weaver, IC, Champagne, FA, Brown, SEet al.Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 2005;25:11045–11054.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.