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Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

Published online by Cambridge University Press:  16 April 2020

J.J. Mann  and
D.M. Currier
J.J. Mann*
Affiliation:
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY10032, United States
D.M. Currier
Affiliation:
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY10032, United States
*
*Corresponding author. Tel.: +212 543 5571; fax: +212 543 6017. E-mail addresses:jjm@columbia.edu (J.J. Mann).
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Abstract

Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.

Keywords

SuicideSuicidal behaviorMajor depressionEpigeneticsGeneticsEnvironmentWhole-genomeStress
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 268 - 271
Copyright
Copyright © Elsevier Masson SAS 2010

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