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Searching for new markers of panic disorder – the examination of stem cells mobilization and levels of factors involved in their trafficking

  • Jolanta Kucharska-Mazur (a1), Marcin Jabłoński (a1), Maciej Tarnowski (a2), Barbara Dołęgowska (a3), Z. Ratajczak Mariusz (a4) and Jerzy Samochowiec (a1)...

Abstract

Introduction

Regeneration processes are the new target in looking for biological markers of psychiatric disorders.

Aims

In this study, we considered the role of stem cells and factors responsible for their trafficking in panic disorder (PD).

Methods

A group of 30 patients with panic disorder was examined and compared with a group of 30 healthy volunteers. In peripheral blood we have analysed: the number of hematopoetic stem cells – HSC (Lin−/CD45+/CD34+) and HSC (Lin−/CD45+/AC133+), the number of very small embryonic – like stem cells – VSEL (Lin−/CD45−/CD34+) and VSEL (Lin−/CD45−/CD133+) and concentration of stromal derived factor-1 (SDF-1), sphingosine-1-phosphate (S1P), and some proteins of the complement cascade.

Results

Peripheral blood concentration of HSCs (Lin−/CD45+/AC133+) was significantly lower in PD group compared to control group, before and after antidepressant treatment. Peripheral blood concentration of VSEL (Lin−/CD45−/CD133+) was significantly lower in PD group before treatment compared to concentration after treatment. In PD group concentrations of factors involved in stem cell trafficking were statistically significant lower in PD group (before and after treatment) compared to control group.

Conclusion

Examination of regeneration system seems to be useful in PD diagnostics.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Copyright

Corresponding author

*Corresponding author.

Searching for new markers of panic disorder – the examination of stem cells mobilization and levels of factors involved in their trafficking

  • Jolanta Kucharska-Mazur (a1), Marcin Jabłoński (a1), Maciej Tarnowski (a2), Barbara Dołęgowska (a3), Z. Ratajczak Mariusz (a4) and Jerzy Samochowiec (a1)...

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Searching for new markers of panic disorder – the examination of stem cells mobilization and levels of factors involved in their trafficking

  • Jolanta Kucharska-Mazur (a1), Marcin Jabłoński (a1), Maciej Tarnowski (a2), Barbara Dołęgowska (a3), Z. Ratajczak Mariusz (a4) and Jerzy Samochowiec (a1)...
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