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Rasagiline and venlafaxine: The serotonin syndrome

Published online by Cambridge University Press:  23 March 2020

A. Rodriguez Campos ,
L. Rodríguez Andrés ,
G. Medina Ojeda ,
L. Gallardo Borge  and
E. Rybak Koite
L. Rodríguez Andrés
Affiliation:
Hospital Clinico Universitario de Valladolid, Psychiatry Department, Valladolid, Spain
G. Medina Ojeda
Affiliation:
Hospital Clinico Universitario de Valladolid, Psychiatry Department, Valladolid, Spain
L. Gallardo Borge
Affiliation:
Hospital Clinico Universitario de Valladolid, Psychiatry Department, Valladolid, Spain
E. Rybak Koite
Affiliation:
Hospital Clinico Universitario de Valladolid, Psychiatry Department, Valladolid, Spain

Abstract

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Rasagiline is a highly potent irreversible monoamine oxidase (MAO)-B inhibitor, antiparkinsonian drug that may be used with caution in patients treated with antidepressant drugs because of the possible appearance of severe adverse effects. It is presented the case report of a woman treated with rasagiline and venlafaxine that presents confusion and a serotonin syndrome. Pathogenesis, physiopathology and treatment are discussed. Growing evidence suggests that Parkinson disease and depression are linked. Antidepressant drugs and PD treatment should be used with caution because of possible drug interaction.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Psychopharmacology and pharmacoeconomics
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S759
Copyright
Copyright © European Psychiatric Association 2017
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