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Psychosis secondary to indomethacin. A case report

Published online by Cambridge University Press:  13 August 2021

S. Santiago González ,
C. Gómez Sánchez-Lafuente ,
A. Martinez Rico  and
J. Hurtado Molina
S. Santiago González*
Affiliation:
Psychiatry, Malaga Regional Hospital, Málaga, Spain
C. Gómez Sánchez-Lafuente
Affiliation:
Psychiatry, Malaga Regional Hospital, Málaga, Spain
A. Martinez Rico
Affiliation:
Psychiatry, Malaga Regional Hospital, Málaga, Spain
J. Hurtado Molina
Affiliation:
General Practice, Malaga District, Málaga, Spain
*
*Corresponding author.

Abstract

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Introduction

Indomethacin, a non-steroidal anti-inflammatory treatment used in various inflammatory diseases, is one of the drugs that has been related to the appearance of psychotic symptoms as a side effect.

Objectives

Point out the importance of knowing the possible psychiatric symptoms that some drugs can cause as a side effect.

Methods

Description of a clinical case and bibliography review.

Results

We present the case of a 71-year-old woman, with no previous mental health history, who is referred by her primary care physician due to the presence of auditory hallucinations and self-referential ideas. As a somatic history, the patient presented Rheumatoid Arthritis under control by rheumatology and acoustic neuroma, under control by neurosurgery. Treatment with Risperidone was started, up to 2 mg, which helped control her symptoms. After an exhaustive study of her situation, the possibility that her symptoms were a side effect of her usual treatment was raised. It was evidenced that the patient had taken a higher dose of Indomethacin than prescribed by the rheumatologist, reason why its daily intake was suspended, and subsequently an improvement and even suppression of symptoms was seen. Later, due to a misunderstanding, the drug was reintroduced, and symptoms appeared again.

Conclusions

The appearance of psychotic symptoms has been related to the intake of various drugs, including Indomethacin. It is essential to carry out a differential diagnosis if psychotic symptoms appear in the subject.

Disclosure

No significant relationships.

Keywords

IndomethacinCOVID-19
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S658
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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