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Pretreatment Predictors of Early Response Revealed by Quantitative Cerebral Blood Flow in Major Depressive Disorder

Published online by Cambridge University Press:  23 March 2020

Z. Hou ,
Z. Wang ,
W. Jiang ,
Y. Yin ,
Y. Yue ,
Y. Zhang  and
Y. Yuan
Z. Hou
Affiliation:
Zhongda Hospital, Medical School of Southeast University, Department of Psychosomatics and Psychiatry, Nanjing, China
Z. Wang
Affiliation:
Zhongda Hospital, Medical School of Southeast University, Department of Neurology, Nanjing, China
W. Jiang
Affiliation:
Zhongda Hospital, Medical School of Southeast University, Department of Psychosomatics and Psychiatry, Nanjing, China
Y. Yin
Affiliation:
Zhongda Hospital, Medical School of Southeast University, Department of Psychosomatics and Psychiatry, Nanjing, China
Y. Yue
Affiliation:
Zhongda Hospital, Medical School of Southeast University, Department of Psychosomatics and Psychiatry, Nanjing, China
Y. Zhang
Affiliation:
Zhongda Hospital, Medical School of Southeast University, Department of Psychosomatics and Psychiatry, Nanjing, China
Y. Yuan
Affiliation:
Zhongda Hospital, Medical School of Southeast University, Department of Psychosomatics and Psychiatry, Nanjing, China

Abstract

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Objective

The potential pattern of regional cerebral blood flow (rCBF) in major depressive disorder (MDD) underlies different response to antidepressants medication remain unclear. This study aimed to investigate the differences of rCBF between patients with different treatment response.

Methods

Eighty MDD patients [(44 treatment-responsive depression (RD) and 36 non-responding depression (NRD)] and 42 healthy controls (HC) underwent pulsed arterial spin labeling (PASL) scans in magnetic resonance imaging and clinical estimates. The exact rCBF values of each groups were obtained via quantification evaluation.

Results

Compared to NRD, the RD patients showed decreased rCBF values in frontal sensorimotor network (i.e. left paracentral lobule, left medial frontal gyrus, right superior frontal gyrus and right middle frontal gyrus), and further receiver operating curve (ROC) analyses demonstrated that the altered rCBF in these four regions exhibited outstanding performance on distinguishing NRD from RD. The NRD also exhibited reduced rCBF in bilateral cerebellum posterior lobe and right middle occipital gyrus and elevated rCBF in right postcentral gyrus and right middle frontal gyrus as compared to HC.

Conclusions

The decreased rCBF in frontal sensorimotor network appeared to be distinct characteristics for NRD, and might be severed as promising neuroimaging markers to differentiate depressed patients with weak early response to antidepressant medication. These findings expand our understanding of neural substrate underlying the antidepressant efficacy.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-poster walk: Classification of mental disorders and cultural psychiatry
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S225
Copyright
Copyright © European Psychiatric Association 2017
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