Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-10-31T23:40:34.009Z Has data issue: false hasContentIssue false

P03-62 - Markers of thrombogenesis are activated in not-yet treated acute schizophrenia

Published online by Cambridge University Press:  17 April 2020

J. Masopust
Affiliation:
Dpf. of Psychiatry, Hradec Kralove, Czech Republic
R. Maly
Affiliation:
1st Dpt. of Internal Medicine, Hradec Kralove, Czech Republic
C. Andrys
Affiliation:
Institute of Clinical Immunology and Allergology, Hradec Kralove, Czech Republic
L. Hosak
Affiliation:
Dpt. of Psychiatry, University Hospital, Hradec Kralove, Czech Republic

Abstract

Objectives

Antipsychotic treatment has been repeatedly found to be associated with an increased risk for venous thromboembolism (VTE) in schizophrenia. The aim of the study was to ascertain whether markers of thrombogenesis are increased in psychotic patients who have not yet been treated with antipsychotic medication.

Methods

We investigated plasma levels of markers indicating activation of coagulation (D-dimers) and platelets (solubile P-selectin, sP-selectin) in a group of nine men and nine women with acute schizophrenia who had not yet been treated with antipsychotics (age 29.8±9.1 years; body mass index 23.3±5.1), and eighteen healthy volunteers matched for age, gender and body mass index.

Results

D-dimers (median 0.38 vs 0.22 mg/l; P=0.049) as well as sP-selectin (median 195.9 vs 111.9 ng/ml; P=0.008) plasma levels were significantly increased in the group of patients with acute schizophrenia as compared to healthy volunteers.

Conclusions

The results suggest that at least a part of venous thromboembolic events in patients with schizophrenia may rather be induced by pathogenetic mechanisms related to psychosis than caused by antipsychotic treatment. Finding an exact cause of VTE in schizophrenia is necessary for its efficient treatment and prevention. We are aware of the pilot character of our data, and continue to involve more patients and healthy volunteers into the research.

Type
Psychotic disorders / Schizophrenia
Copyright
Copyright © European Psychiatric Association 2010

The study has been supported by the Research Project of the Ministry of Health of the Czech Republic MZO 00179906

Submit a response

Comments

No Comments have been published for this article.