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P0220 - Effect of menopause and use of contraceptives/hormone therapy on association of C-reactive protein and depression: A population-based study

Published online by Cambridge University Press:  16 April 2020

T. Liukkonen ,
M. Vanhala ,
J. Jokelainen ,
S. Keinänen-Kiukaanniemi ,
H. Koponen  and
M. Timonen
T. Liukkonen
Affiliation:
Savonlinna Central Hospital, Department of Psychiatry, Savonlinna, Finland University of Oulu, Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
M. Vanhala
Affiliation:
Laukaa Health Centre, Laukaa, Finland Centre Finland Central Hospital, Unit of General Practice, Jyväskylä, Finland Family Practice Unit, Kuopio University and Kuopio University Hospital, Kuopio, Finland
J. Jokelainen
Affiliation:
University of Oulu, Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland Oulu University Hospital, Unit of General Practice, Oulu, Finland
S. Keinänen-Kiukaanniemi
Affiliation:
University of Oulu, Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland Oulu University Hospital, Unit of General Practice, Oulu, Finland Oulu Health Centre, Oulu, Finland
H. Koponen
Affiliation:
Kuopio University Hospital, Department of Psychiatry and The Academy of Finland, Kuopio, Finland
M. Timonen
Affiliation:
University of Oulu, Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland

Abstract

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Background:

Unipolar depression has been found to associate with elevated C-reactive protein levels (CRP) in men, but findings among women have been conflicting. It has been hypothesized that this would be explained by a different hormonal environment (compared with men) and its changes throughout the lifecycle in women, but until now, the corresponding evidence has been lacking. We investigated the association between depressive symptoms and CRP levels in a population-based study in pre-, peri- and postmenopausal women, and also, whether this association is affected by the use of exogenous hormones (contraceptives and postmenopausal hormone therapy).

Methods:

Initially, the entire age classes of those born in 1942, 1947, 1952, 1957 and 1962, and living in Pieksämäki, Finland were invited (N=1,294), and out of 730 women 512 (70.1 %) participated in this cross-sectional study in 1997-98. Depressive symptoms were assessed by Beck's Depression Inventory -21 (BDI-21) and C-reactive protein (CRP) was measured with a high-sensitivity CRP assay (hs-CRP).

Results:

We found a statistically significant positive correlation between hs-CRP-levels and depressive symptoms in peri- and postmenopausal women not using exogenous hormones (Spearman partial correlation coefficient, r=0.189, p=0.011; and r=0.436, p=0.033, respectively). On the contrary, no significant correlations were found in peri- and postmenopausal women using exogenous hormones, or in premenopausal women irrespective of their exogenous hormone use.

Conclusions:

Our novel findings strongly suggest that female hormones might have a major impact on the association between elevated CRP levels and depressive symptoms in females. Further studies are, however, needed to confirm our findings.

Type
Poster Session II: Depression
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S257
Copyright
Copyright © European Psychiatric Association 2008
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