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No association between polymorphisms in three genes of cytochrome p450 family and paranoid schizophrenia in northern Chinese Han population

Published online by Cambridge University Press:  16 April 2020

Yanbin Jia ,
Xin Yu ,
Boyu Zhang ,
Yanbo Yuan ,
Qi Xu ,
Yucun Shen  and
Yan Shen
Yanbin Jia
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
Xin Yu
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Boyu Zhang
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
Yanbo Yuan
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Qi Xu
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
Yucun Shen
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Yan Shen*
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
*
*Corresponding author. Email address: sheny@ms.imicams.ac.cn (Y. Shen).
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Abstract

We genotyped six SNPs in the genes of p450 family among paranoid schizophrenics and normal controls. All subjects are unrelated Han Chinese. Three showed polymorphic, and no significant differences in allele or genotype frequencies were detected between patients and controls. Thus we obtained no evidence for the involvement of the polymorphisms in paranoid schizophrenia in the population investigated.

Keywords

SchizophreniaAssociation studySNPCytochrome p450
Type
Short communication
Information
European Psychiatry , Volume 19 , Issue 6 , September 2004 , pp. 374 - 376
Copyright
Copyright © 2004 European Psychiatric Association

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References

Bassett, AS. Chromosomal aberrations and schizophrenia. Autosomes. Br J Psychiatry 1992;161:323–34.CrossRefGoogle ScholarPubMed
Dahl, ML. Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing? Clin Pharmacokinet 2002;41(7):453–70.CrossRefGoogle ScholarPubMed
Dean, B. Understanding the pathology of schizophrenia: recent advances from the study of the molecular architecture of postmortem CNS tissue. Postgrad Med J 2002;78(917):142–8.CrossRefGoogle Scholar
Ekelund, JLichtermann, DHovatta, IEllonen, PSuvisaari, JTerwilliger, JD, et al. Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum Mol Genet 2000;9(7):1049–57.CrossRefGoogle ScholarPubMed
Hayney, MSPoland, GALipsky, JJ. A noninvasive ‘swish and spit’ method for collecting nucleated cells for HLA typing by PCR in population studies. Hum Hered 1996;46(2):108–11.CrossRefGoogle ScholarPubMed
Lewis, CMLevinson, DFWise, LHDe Lisi, LEStraub, REHovatta, I, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 2003;73(1):34–48.CrossRefGoogle ScholarPubMed
Lichtermann, DKarbe, EMaier, W. The genetic epidemiology of schizophrenia and of schizophrenia spectrum disorders. Eur Arch Psychiatry Clin Neurosci 2000;250(6):304–10.CrossRefGoogle ScholarPubMed
Mowry, BJEwen, KRNancarrow, DJLennon, DPNertney, DAJones, HL, et al. Second stage of a genome scan of schizophrenia: study of five positive regions in an expanded sample. Am J Med Genet 2000;96(6):864–9.3.0.CO;2-D>CrossRefGoogle Scholar
Stormer, EBrockmoller, JRoots, ISchmider, J. Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl) 2000;151(4):312–20.Google ScholarPubMed
Thaker, GKCarpenter, WT Jr. Advances in schizophrenia. Nat Med 2001;7(6):667–71.CrossRefGoogle Scholar
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