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The MINDVIEW project: First results

  • José M. Benlloch (a1), Antonio J. González (a1), Roberto Pani (a2), Enrico Preziosi (a2), Carl Jackson (a3), John Murphy (a3), Julio Barberá (a4), Carlos Correcher (a4), Sebastian Aussenhofer (a5), Daniel Gareis (a5), Dimitris Visvikis (a6), Julien Bert (a6), Bengt Langstrom (a7), Lars Farde (a8) (a9), Miklos Toth (a8), Jenny Haggkvist (a8), Fabio V. Caixeta (a9), Klas Kullander (a9), Ian Somlai-Schweiger (a10) and Markus Schwaiger (a10)...

Abstract

We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from 11C-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that 11C-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naïve, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia.

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Corresponding author

*Corresponding author. E-mail address: agonzalez@i3m.upv.es

References

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Keywords

The MINDVIEW project: First results

  • José M. Benlloch (a1), Antonio J. González (a1), Roberto Pani (a2), Enrico Preziosi (a2), Carl Jackson (a3), John Murphy (a3), Julio Barberá (a4), Carlos Correcher (a4), Sebastian Aussenhofer (a5), Daniel Gareis (a5), Dimitris Visvikis (a6), Julien Bert (a6), Bengt Langstrom (a7), Lars Farde (a8) (a9), Miklos Toth (a8), Jenny Haggkvist (a8), Fabio V. Caixeta (a9), Klas Kullander (a9), Ian Somlai-Schweiger (a10) and Markus Schwaiger (a10)...

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The MINDVIEW project: First results

  • José M. Benlloch (a1), Antonio J. González (a1), Roberto Pani (a2), Enrico Preziosi (a2), Carl Jackson (a3), John Murphy (a3), Julio Barberá (a4), Carlos Correcher (a4), Sebastian Aussenhofer (a5), Daniel Gareis (a5), Dimitris Visvikis (a6), Julien Bert (a6), Bengt Langstrom (a7), Lars Farde (a8) (a9), Miklos Toth (a8), Jenny Haggkvist (a8), Fabio V. Caixeta (a9), Klas Kullander (a9), Ian Somlai-Schweiger (a10) and Markus Schwaiger (a10)...
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