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Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia

Published online by Cambridge University Press:  16 April 2020

Filip Spaniel ,
Vit Herynek ,
Tomas Hajek ,
Monika Dezortova ,
Jiri Horacek ,
Milan Hajek ,
Jiri Kozeny ,
Colleen Dockery  and
Cyril Höschl
Filip Spaniel*
Affiliation:
Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic 3rd School of Medicine, Charles University, Prague, Czech Republic
Vit Herynek*
Affiliation:
MR Unit, Department of Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Tomas Hajek
Affiliation:
Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic 3rd School of Medicine, Charles University, Prague, Czech Republic
Monika Dezortova
Affiliation:
MR Unit, Department of Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Jiri Horacek
Affiliation:
Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic 3rd School of Medicine, Charles University, Prague, Czech Republic
Milan Hajek
Affiliation:
MR Unit, Department of Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Jiri Kozeny
Affiliation:
Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
Colleen Dockery
Affiliation:
Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
Cyril Höschl
Affiliation:
Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic 3rd School of Medicine, Charles University, Prague, Czech Republic
*
*Corresponding author. E-mail address: spaniel@pcp.lf3.cuni.cz
*Corresponding author. E-mail address: spaniel@pcp.lf3.cuni.cz
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Abstract

T1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14 healthy MZ twins.

Keywords

MR relaxometryT1 relaxation timesT2 relaxation timesMonozygotic twinsSchizophreniaGlobus pallidus
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 1 , January 2005 , pp. 41 - 44
Copyright
Copyright © Elsevier SAS 2005

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Footnotes

1

These authors contributed equally to this paper.

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