Hostname: page-component-848d4c4894-75dct Total loading time: 0 Render date: 2024-05-12T17:47:40.131Z Has data issue: false hasContentIssue false
  • English
  • Français

Lithium augmentation in venlafaxine non-responders: an open study

Published online by Cambridge University Press:  16 April 2020

G. Bertschy ,
E. Ragama-Pardos ,
A. Aït-Ameur ,
M. Muscionico ,
S. Favre  and
L. Roth
G. Bertschy*
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
E. Ragama-Pardos
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
A. Aït-Ameur
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
S. Favre
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
L. Roth
Affiliation:
Clinic of Adult Psychiatry, Department of Psychiatry, Geneva University, 2, ch. du Petit Bel-Air, Chene-Bourg, 1225Geneva, Switzerland
*
*Corresponding author. E-mail address: gilles.bertschy@hcuge.ch (G. Bertschy).
Get access

Abstract

Thirteen major depressive patients not responding to a 4-week venlafaxine 300 mg treatment were eligible for a 4-week open trial of lithium addition. Two patients had to stop lithium for a possible moderate serotonin syndrome and five patients became responders, including one dramatic response and two semi-rapid responses.

Keywords

VenlafaxineLithiumDepressionResistance
Type
Short communication
Information
European Psychiatry , Volume 18 , Issue 6 , October 2003 , pp. 314 - 317
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bauer, M, Dopfmer, S. Lithium augmentation in treatment-resistant depression: meta-analysis of placebo-controlled studies. J Clin Psychopharmacol 1999;19:427-34.CrossRefGoogle ScholarPubMed
Baumann, P, Nil, R, Souche, A, Montaldi, S, Baettig, D, Lambert, S, et al. A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation. J Clin Psychopharmacol 1996;16:307-14.CrossRefGoogle ScholarPubMed
Bschor, T, Canata, B, Muller-Oerlinghausen, B, Bauer, M. Predictors of response to lithium augmentation in tricyclic antidepressant-resistant depression. J Affect Disord 2001;64:261-5.CrossRefGoogle ScholarPubMed
Burnett, FE, Dinan, TG. Venlafaxine: pharmacology and therapeutic potential in the treatment of depression. Hum Psychopharmacol 1998;13:153-62.3.0.CO;2-S>CrossRefGoogle Scholar
Charney, DS, Berman, RM, Miller, HL. Treatment of depression. 2nd ed. In: Schatzberg, AF, Nemeroff, CB, The American Psychiatric Press textbook of psychopharmacology. Washington (DC): The American Psychiatric Press; 1998. p. 705-31.Google Scholar
de Montigny, C, Cournoyer, G, Morissette, R, Langlois, R, Caille, G. Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression: correlations with the neurobiologic actions of tricyclic antidepressant drugs and lithium ion on the serotonin system. Arch Gen Psychiatry 1983;40:1327-34.CrossRefGoogle ScholarPubMed
de Montigny, C, Grunberg, F, Mayer, A, Deschenes, JP. Lithium induces rapid relief of depression in tricyclic antidepressant drug non-responders. Br J Psychiatry 1981;138:252-6.CrossRefGoogle ScholarPubMed
de Montigny, C, Silverstone, PH, Debonnel, G, Blier, P, Bakish, D. Venlafaxine in treatment-resistant major depression: a Canadian multicenter, open-label trial. J Clin Psychopharmacol 1999;19:401-6.CrossRefGoogle ScholarPubMed
Gentil, V, Kerr-Correa, F, Moreno, R, D’Arrigo Busnello, E, De Campos, JA, Juruena, MF, et al. Double-blind comparison of venlafaxine and amitriptyline in outpatients with major depression with or without melancholia. J Psychopharmacol 2000;14:61-6.CrossRefGoogle ScholarPubMed
Hegerl, U, Bottlender, R, Gallinat, J, Kuss, HJ, Ackenheil, M, Moller, HJ. The serotonin syndrome scale: first results on validity. Eur Arch Psychiatry Clin Neurosci 1998;248:96-103.CrossRefGoogle ScholarPubMed
Hoencamp, E, Haffmans, J, Dijken, WA, Huijbrechts, IP. Lithium augmentation of venlafaxine: an open-label trial. J Clin Psychopharmacol 2000;20:538-43.CrossRefGoogle Scholar
Katona, CL, Abou-Saleh, MT, Harrison, DA, Nairac, BA, Edwards, DR, Lock, T, et al. Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine. Br J Psychiatry 1995;166:80-6.CrossRefGoogle ScholarPubMed
Lejoyeux, M, Adès, J, Rouillon, F. Serotonin syndrome: incidence, symptoms and treatment. CNS Drugs 1994;2:132-43.CrossRefGoogle Scholar
Mekler, G, Woggon, B. A case of serotonin syndrome caused by venlafaxine and lithium. Pharmacopsychiatry 1997;30:272-3.CrossRefGoogle ScholarPubMed
Montgomery, SA, Asberg, M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382-9.CrossRefGoogle ScholarPubMed
Nierenberg, AA, Adler, LA, Peselow, E, Zornberg, G, Rosenthal, M. Trazodone for antidepressant-associated insomnia. Am J Psychiatry 1994;151:1069-72.Google ScholarPubMed
Nierenberg, AA, Feighner, JP, Rudolph, R, Cole, JO, Sullivan, J. Venlafaxine for treatment-resistant unipolar depression. J Clin Psychopharmacol 1994;14:419-23.CrossRefGoogle ScholarPubMed
Ontiveros, A, Fontaine, R, Elie, R. Refractory depression: the addition of lithium to fluoxetine or desipramine. Acta Psychiatr Scand 1991;83:188-92.CrossRefGoogle ScholarPubMed
Perry, P, Alexander, B, Prince, R, Dunner, F. The utility of a single-point dosing protocol for predicting steady-state lithium levels. Br J Psychiatry 1986;148:401-5.CrossRefGoogle ScholarPubMed
Poirier, MF, Boyer, P. Venlafaxine and paroxetine in treatment-resistant depression: double-blind, randomised comparison. Br J Psychiatry 1999;175:12-6.CrossRefGoogle ScholarPubMed
Walter, G, Lyndon, B, Kubb, R. Lithium augmentation of venlafaxine in adolescent major depression. Aust N Z J Psychiatry 1998;32:457-9.CrossRefGoogle ScholarPubMed
Zullino, D, Preisig, M, Baumann, P. Lithium augmentation in venlafaxine-refactory depression. J Clin Psychopharmacol 2001;21:242-3.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.