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Factors influencing depression endpoints research (FINDER): Study design and population characteristics

Published online by Cambridge University Press:  16 April 2020

Ana Garcia-Cebrian ,
Michael Bauer ,
Angel L. Montejo ,
Nicolas Dantchev ,
Koen Demyttenaere ,
Paul Gandhi ,
Luigi Grassi ,
Brigitta U. Monz ,
David G.S. Perahia  and
Deborah Quail
...Show all authors
Ana Garcia-Cebrian
Affiliation:
Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, SurreyGU20 6PH, UK
Michael Bauer*
Affiliation:
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrae 74, D-01307Dresden, Germany
Angel L. Montejo
Affiliation:
Hospital Universitario Salamanca, Avda Comuneros 27, Salamanca37003, Spain
Nicolas Dantchev
Affiliation:
Unite de Psychiatrie, Hotel-Dieu, 1 place du Parvis Notre Dame, 75004Paris, France
Koen Demyttenaere
Affiliation:
Universitair Ziekenhuis Gasthuisberg, Herestraat 49, 3000Leuven, Belgium
Paul Gandhi
Affiliation:
Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, SurreyGU20 6PH, UK
Luigi Grassi
Affiliation:
University of Ferrara, Corso Giovecca 203, 44100Ferrara, Italy
Brigitta U. Monz
Affiliation:
Boehringer Ingelheim GmbH, D-55216Ingelheim, Germany
David G.S. Perahia
Affiliation:
Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, SurreyGU20 6PH, UK The Gordon Hospital, Bloomburg Street, LondonSW1V 2RH, UK
Deborah Quail
Affiliation:
Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, SurreyGU20 6PH, UK
Andre Tylee
Affiliation:
Section of Primary Care Mental Health, Health Services and Population Research Department, Institute of Psychiatry, De Crespigny Park, Denmark Hill, LondonSE5 8AF, UK
*
* Corresponding author. Tel.: +49 351 458 2772; fax: +49 351 458 43 24.
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Abstract

Factors influencing outcomes of depression in clinical practice, especially health-related quality of life (HRQoL), are poorly understood. The Factors Influencing Depression Endpoints Research (FINDER) study is a European prospective, observational study designed to estimate the HRQoL of adults with a clinically diagnosed depressive episode at baseline, and 3 and 6 months after commencing antidepressant medication. We report here the study design and baseline patient characteristics.

HRQoL was assessed by the 36-item Short-Form Health Survey (SF-36) and European Quality of Life-5 Dimensions (EQ-5D). Patient ratings on Hospital Anxiety and Depression Scale (HADS) and pain Visual Analogue Scale (VAS) were also obtained. Results (n = 3468) showed that SF-36 mental component summary (mean 22.2) was more than two SDs below general population norms (mean 50.0) and one SD below clinical depression norms (mean 34.8); the physical component summary (mean 46.1) was similar to general population (mean 50.0) and clinical depression norms (mean 45.0). Mean EQ-5D scores were also lower than general population norms. Mean HADS-Depression and -Anxiety subscores were 12.3 and 13.0, respectively. Fifty-six percent of patients reported an overall pain VAS score of at least 30 mm and 70% of these patients had no physical explanation for their pain.

Further investigation into factors associated with HRQoL in depression after treatment initiation is warranted.

Keywords

DepressionEuropeObservational studyQuality of life
Type
Original articles
Information
European Psychiatry , Volume 23 , Issue 1 , January 2008 , pp. 57 - 65
Copyright
Copyright © Elsevier Masson SAS 2008

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Footnotes

☆

FINDER was funded by Eli Lilly and Company Limited, Windleham, UK and Boehringer Ingelheim GmbH, Ingelheim, Germany.

1

Dr Paul Gandhi was employed by Eli Lilly and Company Limited, Basingstoke, UK at the time the research was performed.

2

Tel.: +44 1276 483028 (office); fax: +44 (0) 1276 483192.

3

Tel.: +34 923 12 65 96/97 (office); fax: +34 923 26 54 82.

4

Tel.: +33 142 34 84 35 (office); fax: +33 142 34 84 33.

5

Tel.: +32 163 48705 (office); fax: +32 163 48700.

6

Tel.: +39 0532 236 409 (office); fax: +39 0532 212240.

7

Tel.: +49 6132 779 3362 (office); fax: +49 6132 774233.

8

Tel.: +44 1276 483755 (office); fax: +44 (0) 1276 483711.

9

Tel.: +44 20 8746 8733; fax: +44 (0) 20 8746 8711.

10

Tel.: +44 1276 483293 (office); fax: +44 (0) 1276 484800.

11

Tel.: +44 20 7848 0150 (office); fax: +44 (0) 20 7848 0333.

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