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Exposure to tobacco smoke in utero or during early childhood and risk of hypomania: Prospective birth cohort study

Published online by Cambridge University Press:  23 March 2020

D.F. Mackay ,
J.J. Anderson ,
J.P. Pell ,
S. Zammit  and
D.J. Smith
D.F. Mackay*
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
J.J. Anderson
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
J.P. Pell
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
S. Zammit
Affiliation:
Department of psychological medicine and clinical neurosciences, school of medicine, Cardiff university, Cardiff, Wales, United Kingdom
D.J. Smith
Affiliation:
Institute of health & wellbeing, university of Glasgow 1, Lilybank Gardens, G12 8RZGlasgow, Scotland, United Kingdom
*
*Corresponding author. Tel.: +0141 330 2567. E-mail address:Daniel.Mackay@Glasgow.ac.uk (D.F. Mackay).
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Abstract

Objectives

Using data from a prospective birth cohort, we aimed to test for an association between exposure to tobacco smoke in utero or during early development and the experience of hypomania assessed in young adulthood.

Methods

We used data on 2957 participants from a large birth cohort (Avon longitudinal study of parents and children [ALSPAC]). The primary outcome of interest was hypomania, and the secondary outcome was “hypomania plus previous psychotic experiences (PE)”. Maternally-reported smoking during pregnancy, paternal smoking and exposure to environmental tobacco smoke (ETS) in childhood were the exposures of interest. Multivariable logistic regression was used and estimates of association were adjusted for socio-economic, lifestyle and obstetric factors.

Results

There was weak evidence of an association between exposure to maternal smoking in utero and lifetime hypomania. However, there was a strong association of maternal smoking during pregnancy within the sub-group of individuals with hypomania who had also experienced psychotic symptoms (OR = 3.45; 95% CI: 1.49–7.98; P = 0.004). There was no association between paternal smoking, or exposure to ETS during childhood, and hypomania outcomes.

Conclusions

Exposure to smoking in utero may be a risk factor for more severe forms of psychopathology on the mood-psychosis spectrum, rather than DSM-defined bipolar disorder.

Keywords

TobaccoPsychosesPost-partumNicotineBipolar disorder
Type
Original article
Information
European Psychiatry , Volume 39 , January 2017 , pp. 33 - 39
Copyright
Copyright © Elsevier Masson SAS 2017

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