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EPA-1437 - Incidence of Cancer among People with Serious Mental Illness

Published online by Cambridge University Press:  15 April 2020

C. Chang
Affiliation:
Psychological Medicine Department, Institute of Psychiatry, London, United Kingdom
R.D. Hayes
Affiliation:
Psychological Medicine Department, Institute of Psychiatry, London, United Kingdom
M. Broadbent
Affiliation:
Psychological Medicine Department, Institute of Psychiatry, London, United Kingdom
M. Hotopf
Affiliation:
Psychological Medicine Department, Institute of Psychiatry, London, United Kingdom
E. Davies
Affiliation:
Psychological Medicine Department, Institute of Psychiatry, London, United Kingdom
H. Møller
Affiliation:
Psychological Medicine Department, Institute of Psychiatry, London, United Kingdom
R. Stewart
Affiliation:
Psychological Medicine Department, Institute of Psychiatry, London, United Kingdom

Abstract

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Introduction

Higher all-cause mortality and shorter life expectancies for people with severe mental illness (SMI, including schizophrenia, schizoaffective disorder, and bipolar disorder) have been frequently reported. Cancer contributes a substantial proportion of mortality (20 to 30%) as the second or third leading cause of death among people with SMI. Outcomes of cancer incidence studies in SMI were considerably heterogeneous, varying by cancer types and mental disorders.

Objectives/Aims

To compare the incidence of overall and each type of cancer between people with SMI in southeast London and general population in UK.

Methods

Using the anonymised linkage between a regional monopoly secondary mental health service provider covering four southeast London boroughs and a population-based cancer register, we carried out the comparisons of cancer incidences between people with SMI and general population by age- and gender-standardisation in 2011.

Results

Among SMI subjects with cancer (N=105), the most common cancer types were lung and colorectal cancer followed by breast cancer for women and prostate cancer for men in this area. Standardised incidence ratios (SIRs) for all cancers in SMI were 1.19 (95% CI: 0.97-1.44) overall, 2.43 (95% CI: 1.98-2.94) in men (n=61), and 0.98 (95% CI: 0.71-1.31) in women (n=44). Based on relatively small case numbers, raised SIRs were found for lung cancer in men (SIR=7.57, 95% CI: 3.04-15.6) and women (SIR=7.61, 95% CI: 2.79-16.6), and in women for colorectal (SIR=7.85, 95%CI: 2.55-18.32) and breast cancer (SIR=7.86, 95% CI: 4.58-12.59).

Conclusions

Specific pattern of elevated risks of cancer incidence were found for people with SMI.

Type
EPW30 - Psychiatry and Somatic diseases
Copyright
Copyright © European Psychiatric Association 2014
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