Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-23T19:09:07.181Z Has data issue: false hasContentIssue false
  • English
  • Français

EPA-0048 - Relationships Between Serum Total Antioxidant Capacity and Typical/atypical Antipsychotic Treatment in Acute Paranoid Schizophrenia

Published online by Cambridge University Press:  15 April 2020

E. Diaz-Mesa ,
A. Morera-Fumero ,
P. Abreu-Gonzalez ,
M. Henry-Benitez ,
L. Fernandez-Lopez ,
S. Yelmo-Cruz  and
R. Gracia-Marco
E. Diaz-Mesa
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain
A. Morera-Fumero
Affiliation:
Internal Medicine Dermatology and Psychiatry, School of Medicine, University of La Laguna
P. Abreu-Gonzalez
Affiliation:
Physiology, School of Medicine. University of La Laguna, Santa Cruz de Tenerife, Spain
M. Henry-Benitez
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain
L. Fernandez-Lopez
Affiliation:
Internal Medicine Dermatology and Psychiatry, School of Medicine, University of La Laguna
S. Yelmo-Cruz
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain
R. Gracia-Marco
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction:

Schizophrenia is a chronic disease characterized by disturbances of thought, perception, volition, affectivity and cognition. An imbalance of the oxidant-antioxidant system is one of the proposed etiological factors. There are controversies regarding the effect of antipsychotics on the oxidant-antioxidant balance.

Objective:

The aim of this research is to study the serum levels of the total antioxidant capacity (TAC) in paranoid schizophrenia patients treated with typical and/or atypical antipsychotics.

Methods:

The sample is comprised by 38 patients admitted to the psychiatric ward of the University Hospital of the Canary Islands. All patients met DSM-IV criteria for paranoid schizophrenia. Some patients were treated only with atypical antipsychotics (N=21) while others were treated with a combination of atypical and typical antipsychotics (N=17).

Results:

The next table shows the comparison of serum TAC levels at admission (TAC-A) and discharge (TAC-D) at 12:00 and 00:00 h.

 AntipsychoticsMeanS.DP
TAC-A-12Only Atypical0.66330.142150.952
Typical+Atypical0.66040.14889
TAC-A-00Only Atypical0.60040.150620.626
Typical+Atypical0.62470.16163
TAC-D-12Only Atypical0.60700.160670.019
Typical+Atypical0.71720.07654
TAC-D-00Only Atypical0.60010.161710.153
Typical+Atypical0.68360.07842

Patients treated with a combination of typical and atypical antipsychotics present at discharge (12:00 hours) significantly higher levels of TAC than patients treated only with typical antipsychotics. The remaining comparisons did not elicit significant results.

Conclusions:

The results point out the fact that a combination of typical and atypical antipsychotics is more helpful in reducing the deficits of the antioxidant system than treatments based only on typical antipsychotics.

Type
EPW01 - Schizophrenia 1
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
Submit a response

Comments

No Comments have been published for this article.