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Determining the cut-off for recurrent depressive episode to predict diagnostic conversion from unipolar depression to bipolar disorder: 5-year retrospective study in one university hospital

Published online by Cambridge University Press:  23 March 2020

W.M. Bahk
Affiliation:
Yeouido St. Mary's Hospital, Psychiatry, Seoul, Republic of Korea
Y.S. Woo
Affiliation:
Yeouido St. Mary's Hospital, Psychiatry, Seoul, Republic of Korea
H.R. Wang
Affiliation:
Yeouido St. Mary's Hospital, Psychiatry, Seoul, Republic of Korea
B.H. Yoon
Affiliation:
Naju National Hospital, Psychiatry, Naju, Republic of Korea
D.I. Jon
Affiliation:
Sacred Heart Hospital, Hallym University, Psychiatry, Anyang, Republic of Korea
Y.J. Kwon
Affiliation:
Soonchunhyang Cheonan Hospital, Psychiatry, Cheona, Republic of Korea
K.H. Lee
Affiliation:
College of Medicine, Dongguk University, Psychiatry, Gyeongju, Republic of Korea
K.J. Min
Affiliation:
College of Medicine, Chung-Ang University, Psychiatry, Seoul, Republic of Korea
S.Y. Lee
Affiliation:
Wonkwang University School of Medicine, Psychiatry, Iksan, Republic of Korea
M.D. Kim
Affiliation:
College of Medicine, Jeju National University, Psychiatry, Jeju, Republic of Korea

Abstract

Objectives

The aim of this study was to determining the cut-off for recurrent depressive episode to predict diagnostic conversion from unipolar depression to bipolar disorder by means of retrospective reviews of medical records.

Methods

The medical records of 250 patients with a diagnosis of major depressive disorder for at least 5 years were retrospectively reviewed for this study. We reviewed DSM-IV diagnosis and detailed clinical information at the index admission with assessments made every year after discharge to determining the cut-off for recurrent depressive episode to predict diagnostic conversion from unipolar depression to bipolar disorder.

Results

Receiver operating characteristic curve analysis indicated cut-off scores for recurrent depressive episode of more than three times (area under curve = 0.647, sensitivity = 0.435, specificity = 0.819, positive predictive value = 0.351, negative predictive value = 0.865).

Conclusions

These findings suggest that it could predict the best diagnostic conversion from unipolar depression to bipolar disorder when depressive episodes are recurrent more than three times. Based on these findings, it will be able to promote the accuracy of diagnosis and the efficiency of treatment.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW23
Copyright
Copyright © European Psychiatric Association 2016
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Determining the cut-off for recurrent depressive episode to predict diagnostic conversion from unipolar depression to bipolar disorder: 5-year retrospective study in one university hospital
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