This paper will examine Criminal Autistic Psychopathy. The vast majority of persons with autism and Asperger's syndrome are highly ethical. A tiny minority who end up in prison or in criminal activities not leading to prison have major empathy and interpersonal difficulties. These can lead to fatal acts of aggression. This paper focuses on differential diagnosis, neuropsychology, neurochemistry, and neuroimaging studies of this very serious and important condition even though it is rare.