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A case of marchiafava bignami disease with frontal cortex involvement and late onset, long-lasting psychiatric symptoms

Published online by Cambridge University Press:  23 March 2020

C. Vecchi*
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
C. Gramaglia
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
A. Feggi
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
I. Coppola
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
S. Di Marco
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
A. Venesia
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
C. Delicato
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
N. Chieppa
Affiliation:
AOU Maggiore della Carità, Psychiatry, Novara, Italy
F. De Marchi
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
R. Cantello
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
P. Zeppegno
Affiliation:
Università del Piemonte Orientale, Translational Medicine, Novara, Italy
*
* Corresponding author.

Abstract

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Aims

To describe the case and management of a patient with marchiafava bignami disease (MBD) with frontal cortical lesions, no specific symptoms at first referral to the emergency room, and late onset of atypical psychiatric symptoms.

Methods

We report the case of a 44-year-old patient with a history of chronic alcohol abuse, eventually diagnosed with MBD.

Results

Magnetic resonance showed lesions in the splenium and in the body of corpus callosum and bilateral lesions of the frontal cortex. The patient showed late-onset atypical psychiatric symptoms, which were drug resistant.

Conclusions

The case we describe seems to support the existing few ones describing cortical involvement in MBD, which suggest that this is associated with a poorer prognosis. Psychiatric symptoms may be challenging to treat because of drug resistance. The involvement of psychiatrists together with neurologists and radiologists, with a consultation–liaison approach has proved important for the achievement of diagnosis and of the most appropriate management and treatment for this patient.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV116
Copyright
Copyright © European Psychiatric Association 2016
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