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Bipolar Disorder, Obesity and Cognitive Impairment

Published online by Cambridge University Press:  23 March 2020

M. La Montagna ,
E. Stella ,
F. Ricci ,
L. Borraccino ,
A.I. Triggiani ,
F. Panza ,
D. Seripa ,
G. Miscio ,
A. Bellomo  and
M. Lozupone
M. La Montagna
Affiliation:
University of Foggia, Department of Mental Health, Foggia, Italy
E. Stella
Affiliation:
University of Foggia, Department of Mental Health, Foggia, Italy
F. Ricci
Affiliation:
University of Foggia, Department of Mental Health, Foggia, Italy
L. Borraccino
Affiliation:
University of Foggia, Department of Mental Health, Foggia, Italy
A.I. Triggiani
Affiliation:
Laboratory of Physiology- University of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy
F. Panza
Affiliation:
IRCCS Casa Sollievo della Sofferenza, Department of Medical Sciences, San Giovanni Rotondo, Italy
D. Seripa
Affiliation:
IRCCS Casa Sollievo della Sofferenza, Department of Medical Sciences, San Giovanni Rotondo, Italy
G. Miscio
Affiliation:
IRCCS Casa Sollievo della Sofferenza, Department of Medical Sciences, San Giovanni Rotondo, Italy
A. Bellomo
Affiliation:
University of Foggia, Department of Mental Health, Foggia, Italy
M. Lozupone
Affiliation:
University of Foggia, Department of Mental Health, Foggia, Italy

Abstract

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Introduction

According to scientific literature, cognitive impairment is a disabling feature of the bipolar disorder (BD), present in all the phases of the disease. Obesity and metabolic disorders represent another risk factor for cognitive dysfunctions in BD, since the excess of weight could adversely influence several cognitive domains.

Objective

To highlight the presence of impairment of cognitive functions in a sample of subjects suffering from BD and obesity.

Aims

Evaluation of the cognitive performance in a sample of BD patients, considering their anthropometric measures (height and weight) and body mass index (BMI).

Methods

The neuropsychological battery MATRICS Consensus Cognitive Battery (MCCB) was administered by trained physicians for the evaluation of seven different cognitive domains in 46 patients (mean age: 43.17 years old; 39.13% male), affected by BD enrolled in the psychiatric unit of Azienda Sanitaria Locale and University of Foggia. In particular, cognitive functions assessed were speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition. BMI was calculated, and patients were divided into a group of normal weight and another one of overweight or obese, on the base of BMI value (BMI cut-off = 25).

Results

The obese patients amounted at 56.52%. We have found the presence of cognitive deficits in two of the seven domains assessed, that are speed of processing (P < 0.01) and reasoning and problem solving (P < 0.05) in the sample of overweight patients.

Conclusions

Cognitive deficits are clearly revealed in BD patients during the euthymic phase of the disorder. The obesity in BD could contribute to increase dysfunctions in cognitive domains.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-poster walk: Bipolar disorders – Part 2
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S207
Copyright
Copyright © European Psychiatric Association 2017
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