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Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern

Published online by Cambridge University Press:  15 April 2020

M. Delavest ,
C. Even ,
N. Benjemaa ,
M.-F. Poirier ,
R. Jockers  and
M.-O. Krebs
M. Delavest
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France
C. Even*
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Clinique des maladies mentales et de l’encéphale, centre hospitalier Sainte-Anne, 100, rue de la Santé, 75014Paris, France
N. Benjemaa
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 7, rue Cabanis, 75014Paris, France
M.-F. Poirier
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 7, rue Cabanis, 75014Paris, France
R. Jockers
Affiliation:
CNRS (UMR 8104), Inserm U567, université Paris Descartes, institut Cochin, 22, rue Méchain, 75014Paris, France
M.-O. Krebs
Affiliation:
Inserm U894, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 7, rue Cabanis, 75014Paris, France
*
*Corresponding author. Tel.: +33 1 45 65 83 71; fax: +33 1 45 65 89 43. E-mail address: c.even@ch-sainte-anne.fr (C. Even).
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Abstract

This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.

Keywords

Seasonal Affective DisordersMood disordersGenetics
Type
Short communications
Information
European Psychiatry , Volume 27 , Issue 5 , July 2012 , pp. 369 - 371
Copyright
Copyright © Elsevier Masson SAS 2012

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