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Assessment of microalbuminuria and ankle-brachial index in outpatients with schizophrenia treated with antipsychotics - a possible predictors of cardiovascular disease

Published online by Cambridge University Press:  16 April 2020

R. Malý
Affiliation:
1st Department of Internal Medicine, Hradec Kralove, Czech Republic
D. Kalnická
Affiliation:
Department of Psychiatry, University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic
J. Masopust
Affiliation:
Department of Psychiatry, University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic
K. Minářová
Affiliation:
Department of Psychiatry, University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic
M. Vašatová
Affiliation:
Institute of Clinical Biochemistry and Diagnostics, University Hospital and Faculty of Medicine, Hradec Králové, Czech Republic
L. Pavlíková
Affiliation:
Institute of Clinical Biochemistry and Diagnostics, University Hospital and Faculty of Medicine, Hradec Králové, Czech Republic
J. Bažant
Affiliation:
Department of Psychiatry, University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic

Abstract

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Schizophrenia and related psychoses are associated with excess morbidity and mortality from cardiovascular (CV) disease. Microalbuminuria (MA) is associated with an increased risk of CV disease and mortality. This association is independent of other known CV risk factors such as hypertension, dyslipidemia, obesity, smoking, and impaired renal function. The ankle brachial index (ABI), which is the ratio of systolic pressure at the ankle to that in the arm, is quick and easy to measure and has been used to confirm the diagnosis and assess the severity of peripheral artery disease. Low ABI has been related to an increased incidence of total and CV mortality and CV events. The objective of prospective pilot study was to determine MA and ABI as well as the prevalence of CV risk factors (glucose tolerance status, lipids levels, obesity, hypertension, smoking) and assessment of Framingham risk score in patients with schizophrenia treated with antipsychotic drugs. The study included thirty-three outpatient subjects (female, n = 16), aged 21–66 years. The exclusion criteria included urinary infection and presence of diabetes mellitus. Three patients (7,7%) has abnormal (>26 mg/d) levels of MA, non of ABI.In conclusion, stratification by MA can help identify a high-risk subset of nondiabetic patients with schizophrenia in risk of CV events.

Type
P03-267
Copyright
Copyright © European Psychiatric Association 2011
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