According to the recommendation of the World Health Organization, and also implementation of atypical antipsychotics in every day clinical practice, consequently the question mark appears regarding use of anticolinergic drugs (i.e. biperiden). Therefore it′s prophylactic administration is not recommended in every day clinical practice, except in younger patients and children receiving high potency typical antipsychotic drugs. In this paper we studied frequency of using, or abusing biperiden, and daily dosage of it, during determinate period of one year on the Acute male and Acute female department of the Psychiatric Hospital ″Sveti Ivan″ in patients diagnosed with schizophrenia. The object was to observe the therapy at the time of discharge. Almost 300 were included schizophrenic patients with average age of 40.6, and with prescription rate of biperiden as high as 38%.