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1473 – Seasonal Pattern In Bipolar Disorder: Prevalence, Clinical Characteristics And Gender Influence

Published online by Cambridge University Press:  15 April 2020

P.A. Geoffroy ,
B. Etain ,
J. Scott ,
C. Boudebesse ,
M. Lajnef ,
M. Leboyer  and
F. Bellivier
P.A. Geoffroy
Affiliation:
Inserm, U 955, Psychiatrie Génétique Fondation FondaMental, Creteil Pôle de Psychiatrie, Université Lille Nord de France, CHRU de Lille, Lille
B. Etain
Affiliation:
Inserm, U 955, Psychiatrie Génétique Fondation FondaMental, Creteil AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil, France
J. Scott
Affiliation:
Fondation FondaMental, Creteil Academic Psychiatry, Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK
C. Boudebesse
Affiliation:
Inserm, U 955, Psychiatrie Génétique Fondation FondaMental, Creteil AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil, France
M. Lajnef
Affiliation:
Inserm, U 955, Psychiatrie Génétique
M. Leboyer
Affiliation:
Inserm, U 955, Psychiatrie Génétique Fondation FondaMental, Creteil Université Paris Est, Faculté de Médecine, Creteil
F. Bellivier
Affiliation:
Inserm, U 955, Psychiatrie Génétique Université Paris Diderot, Faculté de Médecine AP-HP, Hôpital St Louis-Lariboisière-F. Widal, Pôle de Psychiatrie, Paris, France

Abstract

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Introduction

Circadian rhythm pathways are highlighted in a number of etiological models of bipolar disorder (BD). More than 25% of bipolar patients may present seasonal pattern (SP). However, there is very limited scientific data on the prevalence of SP, its clinical manifestations and any gender influence.

Methods

Caucasian individuals who met DSM-IV criteria for BD I or II were recruited from three university-affiliated psychiatric departments in France (Paris, Bordeaux, Nancy). SP was defined according to DSM-IV criteria. Clinical and socio- demographic variables were obtained from structured interviews with the patients and their relatives.

Results

Four hundred and fifty-two bipolar patients (n=452) in euthymic state were included in the study, 102 of them (23%) were considered as having SP according to DSM-IV criteria. Multivariate analysis showed a significant association of BD patients with SP for bipolar II subtype (OR=1.99, p=0.013), rapid cycling (OR=2.04, p=0.02), eating disorder (OR=2.93, p=0.003) and the total number of depressive episodes (OR=1.12, p=0.002). 71% of cases were correctly classified by this analysis. However, when stratifying the analyses by gender, SP was associated with BD II subtype (OR=2.89, p=0.02) and total number of depressive episodes (OR=1.21, p=0.002) in males but with rapid cycling (OR=3.02, p=0.003) and eating disorders (OR=2.60, p=0.02) in females.

Conclusions

The high prevalence of SP in BD, its associated clinical characteristics and the observed differences between genders, suggest that SP represents a potentially important specifier of BD.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E787
Copyright
Copyright © European Psychiatric Association 2013
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