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From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process

  • Arielle R. Deutsch (a1) (a2), Wendy S. Slutske (a1) (a2), Michael T. Lynskey (a2) (a3), Kathleen K. Bucholz (a2), Pamela A. F. Madden (a2), Andrew C. Heath (a2) and Nicholas G. Martin (a4)...

Abstract

The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones.

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Corresponding author

Address correspondence and reprint requests to: Arielle R. Deutsch, Department of Psychological Sciences, University of Missouri–Columbia, 112 Psychology Building, Columbia, MO 65211; E-mail: arielle.deutsch@gmail.com.

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This work was supported by National Institute on Drug Abuse Grant DA18267 and National Institute on Alcohol Abuse and Alcoholism Grants AA07728 and AA023133. We thank Leah Richmond-Rackerd for her feedback on the manuscript; Dixie Statham for coordinating the data collection for the twins; and David Smyth, Olivia Zheng, and Harry Beeby for data management of the Australian Twin Registry. We thank the Australian Twin Registry twins for their continued participation.

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References

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American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
Behar, D., Berg, C. J., Rapoport, J. L., Nelson, W., Linnolia, M., Cohen, M., et al. (1983). Behavioral and physiological effects of ethanol in high-risk and control children: A pilot study. Alcohol: Clinical and Experimental Research, 7, 404410.
Behrendt, S., Buhringer, G., Perkonigg, A., Lieb, R., & Beesdo-Baum, K. (2013). Characteristics of developmentally early alcohol use disorder symptom reports: A prospective-longitudinal community study. Drug and Alcohol Dependence, 131, 308315. doi:10.1016/j.drugalcdep.2012.12.024
Behrendt, S., Wittchen, H., Hofler, M., Lieb, R., Low, N. C. P., Rehm, J., et al. (2009) Risk and speed of transitions to first alcohol dependence symptoms in adolescents: A 10-year longitudinal community study in Germany. Addiction, 103, 16381647. doi:10.1111/j.1360-0443.2008.02324.x
Brown, S. A., McGue, M., Maags, J., Schulenberg, J., Hingson, R., Swartzwelder, S., et al. (2008) A developmental perspective on alcohol and youths from 16 to 20 years of age. Pediatrics, 121, S290S310. doi:10.1542/peds.2007-2243D
Bucholz, K. K., Cadoret, R., Cloninger, C. R., Dinwiddie, S. H., Hesselbrock, V. M., Nurnberger, J. I., et al. (1994). Journal of Studies on Alcohol, 55, 149158.
Buu, A., Wang, W., Schroder, S. A., Kalaida, N. L., Puttler, L. I., & Zucker, R. A. (2012). Developmental emergence of alcohol use disorder symptoms and their potential as early indicators for progression to alcohol dependence in a high-risk sample: A longitudinal study form childhood to early adulthood. Journal of Abnormal Psychology, 121, 897908. doi:1 0.1037/a0024926
Chassin, L., Sher, K. J., Hussong, A., & Currran, P. (2013) Developmental psychopathology of alcohol use and alcohol disorders: Research achievements and future directions. Development and Psychopathology, 25, 15671584. doi:10.1017/S0954579413000771
Chung, T., Martin, C. S., Armstrong, T. D., & Labouvie, E. W. (2002). Prevalence of DSM-IV alcohol diagnoses and symptoms in adolescent community and clinical samples. Journal of the American Academy of Child & Adolescent Psychiatry, 41, 546554. doi:10.1097/00004583-200205000-00012
Chung, T., Martin, C. S., Winters, K. C., & Langenbucher, J. W. (2001). Assessment of alcohol tolerance in adolescents. Journal of Studies in Alcohol, 62, 687695.
Deas, D., Riggs, P., Langenbucher, J., Goldman, M., & Brown, S. (2000). Adolescents are not adults: Developmental considerations in alcohol users. Alcoholism: Clinical and Experimental Research, 24, 232237. doi:10.1111/j.1530-0277.2000.tb04596.x
Deutsch, A. R., Slutske, W. S., Richmond-Rakerd, L. S., Chernyavskiy, P., Heath, A. C., & Martin, N. G. (2013) Causal influence of age at first drink on alcohol involvement in adulthood and its moderation by familial context Journal of Studies on Alcohol and Drugs, 74, 703713.
Enders, C. K., & Tofighi, D. (2007). Centering predictor variables in cross-sectional multilevel models: A new look at an old issue. Psychological Methods, 12, 121138.
Faden, V. B. (2006). Trends initiation of alcohol use in the United States 1975 to 2003. Alcoholism: Clinical and Experimental Research, 30, 10111022. doi:10.1111/j.1530-0277.2006.00115.x
Fowler, T., Lifford, K., Shelton, K., Rice, F., Thapar, A., Neale, M. C., et al. (2007). Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction, 102, 413422. doi:10.1111/j.1360-0443.2006.01694.x
Grant, B. F., & Dawson, D. A. (1997) Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: Results from the National Longitudinal Alcohol Epidemiologic Survey. Journal of Substance Abuse, 9, 103110. doi:10.1016/S0899-3289(97)90009-2
Grant, J. D., Scherrer, J. F., Lynskey, M. T., Lyons, M. J., Eisen, S. A., Tsuang, M. T., et al. (2006). Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: Evidence from a twin design. Psychological Medicine, 1, 109118.
Haller, M., Handley, E., Chassin, L., & Bountress, K. (2010). Developmental cascades: Linking substance use with promoting peers and academic achievement to adult substance use disorders. Development and Psychopathology, 22, 899916. doi:10.1017/S0954579410000532
Harford, T. C., Grant, B. F., Yi, H., & Chen, C. M. (2005) Patterns of DSM-IV alcohol abuse and dependence criteria among adolescents and adults: Results from the 2001 National Household Survey on Drug Abuse. Alcoholism: Clinical and Experimental Research, 29, 810828. doi:10.1097/01.ALC.0000164381.67723.76
Hasin, D. S., Schuckit, M. A., Martin, C. S., Grant, B. F., Bucholz, K. K., & Hezler, J. E. (2003). The validity of DSM-IV alcohol dependence: What do we know and what do we need to know? Alcoholism: Clinical and Experimental Research, 27, 244252. doi:10.1097/01.ALC.0000060878.61384.ED
Hougaard, P. (2014). Frailty models. In Klein, J. P., van Houwelingen, H. C., Ibrahim, J. G., & Scheike, T. H. (Eds.), Handbook of survival analysis (pp. 457474). Boca Raton, FL: CRC Press.
Iacono, W., Malone, S., & McGue, M. (2008). Behavioral disinhibition and the development of early onset addiction: Common and specific influences. Annual Review of Clinical Psychology, 4, 325348. doi:10.1146/annurev.clinpsy.4.022007.141157
Jackson, K. M. (2010). Progression through early drinking milestones in an adolescent treatment sample. Addiction, 105, 438449. doi:10.1111/j.1360-0443.2009.02800.x
Kendler, K. S., Gardner, C., & Dick, D. M. (2011). Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction. Psychological Medicine, 41, 15071516. doi:10.1017/S003329171000190X
Kendler, K. S., Schmitt, J. E., Aggen, S. H., & Prescott, C. A. (2008). Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from adolescence to middle adulthood. Archives of General Psychiatry, 65, 674682. doi:10.1001/archpsyc.65.6.674
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey replication. Archives of General Psychiatry, 62, 593602. doi:10.1001/archpsyc.62.6.593
Keyes, K. M., Martins, S. S., Blanco, C., & Hasin, D. S. (2010). Telescoping and gender differences in alcohol dependence: New evidence from two national surveys. American Journal of Psychiatry, 167, 969976. doi:10.1176/appi.ajp.2009.09081161
King, A. C., Hasin, D., O'Connor, S. J., McNamara, P. J., & Cao, D. (2015). A prospective 5-year re-examination of alcohol response in heavy drinkers progressing in alcohol use disorder. Biological Psychiatry. Advance online publication. doi:10.1016/j.biopsych.2015.05.007
Knopic, V. S., Heath, A. C., Madden, P. A. F., Bucholz, K. K., Slutske, W. S., Nelson, E. C., et al. (2004). Genetic effects on alcohol dependence risk: Re-evaluating the importance of psychiatric and other heritable risk factors. Psychological Medicine, 34, 15191530. doi:10.1017/S0033291704002922
Lee, M. R., & Chassin, L. (2013). Maturing out of alcohol involvement: Transitions in latent drinking statuses from late adolescence to adulthood. Development and Psychopathology, 25, 11371153. doi:10.1017/S0954579413000424
Lynne-Landsman, S. D., Bradshaw, C. P., & Ialongo, N. S. (2010). Testing a developmental cascade model of adolescent substance use trajectories and young adult adjustment. Development and Psychopathology, 22, 933948. doi:10.1017/S0954579410000556
Lynskey, M. T., Heath, A. C., Bucholz, K. K., Slutske, W. S., Madden, P. A. F., Nelson, E. C., et al. (2003). Escalation of drug use in early-onset cannabis users vs co-twin controls. Journal of the American Medical Association, 289, 427433. doi:10.1001/jama.289.4.427
Maggs, J. L., & Schulenberg, J. E. (2004) Trajectories of alcohol use during the transition to adulthood. Alcohol Research and Health, 28, 195201.
Martin, C. S., & Winters, K. C. (1998) Diagnosis and assessment of alcohol use disorders among adolescents. Alcohol Health and Research World, 22, 95105.
Masten, A. S., & Cicchetti, D. (2010). Developmental cascades. Development and Psychopathology, 22, 491495. doi:10.1017/S0954579410000222
McGue, M., Osler, M., & Christensen, K. (2010). Causal inference and observational research: The utility of twins. Perspectives on Psychological Science, 5, 546556. doi:10.1177/1745691610383511
Morean, M. E., Kong, G., Camenga, D. R., Cavallo, D. A., Connell, C., & Krishnan-Sarin, S. (2014). First drink to first drunk: Age of onset and delay to intoxication are associated with adolescent alcohol and binge drinking. Alcoholism: Clinical and Experimental Research, 38, 26152621. doi:10.1111/acer.12526
Osgood, D. W., Ragan, D. T., Wallace, L. Gest, S. D., Feinberg, M. E., & Moody, J. (2013). Peers and the emergence of alcohol use: Influence and selection processes in adolescent friendship networks. Journal of Research on Adolescence, 23, 500512. doi:10.1111/jora.12059
Pagan, J. L., Ros, R. J., Viken, R. J., Pulkken, L., Kaprio, J., & Dick, D. M. (2006). Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood. Behavior Genetics, 36, 483497. doi:10.1007/s10519-006-9062-y
Pollock, N. K., & Martin, C. S. (1999) Diagnostic orphans: Adolescents with alcohol symptom who do not qualify for DSM-IV abuse or dependence diagnoses. American Journal of Psychiatry, 156, 897901. doi:ajp.156.6.897
Prescott, C. A., & Kendler, K. S. (1999). Age at first drink and risk for alcoholism: A noncausal association. Alcoholism: Clinical and Experimental Research, 23, 101107. doi:10.1111/j.1530-0277.1999.tb04029.x
Randall, C. L., Roberts, J. S., Del Boca, F. K., Carroll, K. M., Connors, G. J., & Mattson, M. E. (1999). Telescoping of landmark events associated with drinking: A gender comparison. Journal of Studies on Alcohol and Drugs, 60, 252260.
Ray, L. A., Miranda, R., Chelminski, I., Young, D., & Zimmerman, M. (2008) Diagnostic orphans for alcohol use disorders in a treatment-seeking psychiatric sample. Drug and Alcohol Dependence, 96, 187191. doi:10.1016/j.drugalcdep.2008.03.002
Reifman, A., Barnes, G. M., Dincheft, B. A., Farrell, M. P., & Utheg., L. (1998). Parental and peer influences on the onset of heavier drinking among adolescents. Journal of Studies on Alcohol, 59, 331–317.
Rubin, D. B. (2008). For objective causal inferences, design trumps analysis. Annals of Applied Statistics, 2, 808840. doi:10.1214/08-AOAS187
Sartor, C. E., Lynskey, M. T., Heath, A. C., Jacob, T., & True, W. (2007). The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction, 102, 216225. doi:10.1111/j.1360-0443.2006.01661.x
Schemper, M. (1992). Cox analysis of survival data with non-proportional hazard functions. Statistician, 41, 455465.
Schuckit, M. A., Danko, G. P., Smith, T. L., Bierut, L. J., Bucholz, K. K., Edenberg, H. J., et al. (2008). The prognostic implications of DSM-IV abuse criteria in drinking adolescents. Drug and Alcohol Dependence, 97, 94104. doi:10.1016/j.drugalcdep.2008.03.020
Sher, K. J. (1991). Children of alcoholics: A critical appraisal of theory and research. Chicago: University of Chicago Press.
Sher, K. J., Jackson, K. M., & Steinley, D. (2011). Alcohol use trajectories and the ubiquitous cat's cradle: A cause for concern? Journal of Abnormal Psychology, 120, 322335. doi:10.1037/a0021813
Singer, J. D., & Willett, J. B. (2003). Applied longitudinal data analysis: Modeling change and event occurrence. New York: Oxford University Press.
Snijders, T., & Bosker, R. (1999). Multilevel analysis: An introduction to basic and advanced multilevel modeling. Thousand Oaks, CA: Sage.
Spear, L. P. (2011). Adolescent neurobehavioral characteristics, alcohol sensitivities, and intake: Setting the stage for alcohol use disorders? Child Development Perspectives, 5, 231238. doi:10.1111/j.1750-8606.2011.00182.x
Stallings, M. C., Hewitt, J. K., Beresford, T., Heath, A. C., & Eaves, L. J. (1999). A twin study of drinking and smoking onset and latencies from first use to regular use. Behavior Genetics, 29, 409421. doi:10.1023/A:1021622820644
Waller, M. B., McBride, W. J., Lumeng, L., & Li, T. K. (1983). Initial sensitivity and acute tolerance to ethanol in the P and NP lines of rats. Pharmacology Biochemistry and Behavior, 19, 683686.
Warner, L. A., & White, H. R. (2003). Longitudinal effects of age at onset and first drinking situations on problem drinking. Substance Use and Misuse, 38, 19832016. doi:10.1081/JA-120025123
Windle, M., Spear, L. P., Fuligni, A. J., Angold, A., Brown, J. D., Pine, D., et al. (2008). Transitions into underage and problem drinking summary of developmental processes and mechanisms: Ages 10–15. Pediatrics, 121, S273S289.
Witt, E. D. (2010). Research on alcohol and adolescent brain development: Opportunities and future directions. Alcohol, 44, 119124. doi:10.1016/j.alcohol.2009.08.011
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