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Enduring effect of childhood maltreatment on cortisol and heart rate responses to stress: The moderating role of severity of experiences

  • Isabelle Ouellet-Morin (a1) (a2) (a3), Marie-Pier Robitaille (a1), Stéphanie Langevin (a1), Christina Cantave (a1), Mara Brendgen (a3) (a4) and Sonia J. Lupien (a1) (a2)...

Abstract

There is a relative consensus about the detrimental impact of childhood maltreatment on later mental health problems and behavioral difficulties. Prior research suggests that neurophysiological stress mechanisms may partly mediate this association. However, inconsistent findings regarding hypothalamic-pituitary-adrenal axis and sympathetic responses to stress complicate this investigation. Furthermore, the concordance in these two stress systems is not well understood. We tested whether the severity of maltreatment affected the association between maltreatment and cortisol and heart rate (HR) stress responses and the symmetry of these responses. Participants were 155 males (56 maltreated and 99 controls) aged 18 to 35 years. Cortisol and HR were measured in response to the Trier Social Stress Test. Childhood maltreatment, sociodemographic factors, and health-related factors were measured using self-reported questionnaires. Maltreated participants had higher cortisol responses to stress in comparison to controls. However, a shift from moderate to lower to higher cortisol responses was noted as the severity of the experiences increased. Participants exposed to more experiences of maltreatment also showed a greater symmetry between cortisol and HR stress responses. Our findings provide further support for persistent dysregulation of the HPA axis following childhood maltreatment, of which the expression and symmetry with the sympathetic system may change according to the severity of experiences.

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Corresponding author

Address correspondence and reprint requests to: Isabelle Ouellet-Morin, School of Criminology, University of Montreal, Research Center of the Montreal Mental Health University Institute and the Research Group on Child Maladjustment, C.P. 6128, succursale Centre-ville, Montréal QC, H3C 3J7, Canada; E-mail: isabelle.ouellet-morin@umontreal.ca.

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We are grateful to the participants who have given their time to take part in this study. The data presented in this manuscript have been funded by the HF Guggenheim Foundation. Isabelle Ouellet-Morin is Canada Research Chair in the Developmental Origins of Vulnerability and Resilience, and Stéphanie Langevin is supported by the Fonds de recherche du Québec–Société et Culture. Mara Brendgen was supported by the Fonds de Recherche du Québec-Santé, and Sonia J. Lupien is a Canada Research Chair in Human Stress.

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