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Childhood adversity predicts black young adults’ DNA methylation-based accelerated aging: A dual pathway model

Published online by Cambridge University Press:  20 December 2021

Steven R. H. Beach Open the ORCID record for Steven R. H. Beach [Opens in a new window] ,
Frederick X. Gibbons Open the ORCID record for Frederick X. Gibbons [Opens in a new window] ,
Sierra E. Carter Open the ORCID record for Sierra E. Carter [Opens in a new window] ,
Mei Ling Ong ,
Justin A. Lavner ,
Man-Kit Lei ,
Ronald L. Simons ,
Meg Gerrard  and
Robert A. Philibert
Steven R. H. Beach*
Affiliation:
Department of Psychology, University of Georgia, Athens, GA, USA Center for Family Research, University of Georgia, Athens, GA, USA
Frederick X. Gibbons
Affiliation:
Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA
Sierra E. Carter
Affiliation:
Department of Psychology, Georgia State University, Atlanta, GA, USA
Mei Ling Ong
Affiliation:
Center for Family Research, University of Georgia, Athens, GA, USA
Justin A. Lavner
Affiliation:
Department of Psychology, University of Georgia, Athens, GA, USA Center for Family Research, University of Georgia, Athens, GA, USA
Man-Kit Lei
Affiliation:
Department of Sociology, University of Georgia, Athens, GA, USA
Ronald L. Simons
Affiliation:
Department of Sociology, University of Georgia, Athens, GA, USA
Meg Gerrard
Affiliation:
Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA
Robert A. Philibert
Affiliation:
Department of Psychiatry, University of Iowa, Iowa City, IA, USA Behavioral Diagnostics, Coralville, IA, USA
*
Corresponding author: Steven R. H. Beach, email: srhbeach@uga.edu
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Abstract

We expand upon prior work (Gibbons et al., 2012) relating childhood stressor effects, particularly harsh childhood environments, to risky behavior and ultimately physical health by adding longer-term outcomes – deoxyribonucleic acid (DNA) methylation-based measures of accelerated aging (DNAm-aging). Further, following work on the effects of early exposure to danger (McLaughlin et al., 2014), we also identify an additional pathway from harsh childhood environments to DNAm-aging that we label the danger/FKBP5 pathway, which includes early exposure to dangerous community conditions that are thought to impact glucocorticoid regulation and pro-inflammatory mechanisms. Because different DNAm-aging indices provide different windows on accelerated aging, we contrast effects on early indices of DNAm-aging based on chronological age with later indices that focused on predicting biological outcomes. We utilize data from Family and Community Health Study participants (N = 449) from age 10 to 29. We find that harshness influences parenting, which, in turn, influences accelerated DNAm-aging through the risky cognitions and substance use (i.e., behavioral) pathway outlined by Gibbons et al. (2012). Harshness is also associated with increased exposure to threat/danger, which, in turn, leads to accelerated DNAm-aging through effects on FKBP5 activity and enhanced pro-inflammatory tendencies (i.e., the danger/FKBP5 pathway).

Keywords

discriminationDNAm-agingFKBP5Life History
Type
Special Issue Article
Information
Development and Psychopathology , Volume 34 , Issue 2: Special Issue: Dimensions of early experience and adaptive and maladaptive development , May 2022 , pp. 689 - 703
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© The Author(s), 2021. Published by Cambridge University Press

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