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Reward-related processing in the human brain: Developmental considerations

Published online by Cambridge University Press:  07 October 2008

Dominic S. Fareri ,
Laura N. Martin  and
Mauricio R. Delgado
Dominic S. Fareri
Affiliation:
Rutgers University
Laura N. Martin
Affiliation:
Rutgers University
Mauricio R. Delgado*
Affiliation:
Rutgers University
*
Address correspondence and reprint requests to: Mauricio R. Delgado, Department of Psychology, Smith Hall, Room 340, Rutgers University, 101 Warren Street, Newark, NJ 07102; E-mail: delgado@psychology.rutgers.edu.
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Abstract

The pursuit of rewarding experiences motivates everyday human behavior, and can prove beneficial when pleasurable, positive consequences result (e.g., satisfying hunger, earning a paycheck). However, reward seeking may also be maladaptive and lead to risky decisions with potentially negative long-term consequences (e.g., unprotected sex, drug use). Such risky decision making is often observed during adolescence, a time in which important structural and functional refinements occur in the brain's reward circuitry. Although much of the brain develops before adolescence, critical centers for goal-directed behavior, such as frontal corticobasal ganglia networks, continue to mature. These ongoing changes may underlie the increases in risk-taking behavior often observed during adolescence. Further, typical development of these circuits is vital to our ability to make well-informed decisions; atypical development of the human reward circuitry can have severe implications, as is the case in certain clinical and developmental conditions (e.g., attention-deficit/hyperactivity disorder). This review focuses on current research probing the neural correlates of reward-related processing across human development supporting the current research hypothesis that immature or atypical corticostriatal circuitry may underlie maladaptive behaviors observed in adolescence.

Type
Research Article
Information
Development and Psychopathology , Volume 20 , Special Issue 4: Imaging Brain Systems in Normality and Psychopathology , Fall 2008 , pp. 1191 - 1211
Copyright
Copyright © Cambridge University Press 2008

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Footnotes

The authors acknowledge Marek Mandau for assistance with the figures and the support from the National Institute on Drug Abuse Grant DA022998 (to M.R.D.).

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