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Emotion regulation in children and adolescents: Boundaries between normalcy and bipolar disorder

Published online by Cambridge University Press:  25 October 2006

DANIEL P. DICKSTEIN  and
ELLEN LEIBENLUFT
DANIEL P. DICKSTEIN
Affiliation:
National Institute of Mental Health
ELLEN LEIBENLUFT
Affiliation:
National Institute of Mental Health
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Abstract

Much controversy has surrounded the diagnosis of bipolar disorder (BD) in children and adolescents. However, recent work from an affective neuroscience perspective has advanced what is known about the boundaries of emotion regulation in BD compared to typically developing youth. In this article, we first briefly review the clinical issues that have contributed to this diagnostic controversy. Second, we discuss our phenotyping system, which can be used to guide neurobiological research designed to address these controversial issues. Third, we review what is known about the fundamentals of emotion regulation in human and nonhuman primate models. Fourth, we present recent data demonstrating how children and adolescents with BD differ from those without psychopathology on measures of emotion regulation. Taken as a whole, this work implicates a neural circuit encompassing the prefrontal cortex, amygdala, and striatum in the pathophysiology of pediatric BD.Both authors are affiliated with the Mood and Anxiety Disorders Program of the National Institute of Mental Health's Division of Intramural Research Programs (NIMH DIRP), which funded the work in its entirety. Dr. Dickstein is currently supported by a career development award (K22-MH 74945).

Type
Research Article
Information
Development and Psychopathology , Volume 18 , Issue 4 , December 2006 , pp. 1105 - 1131
Copyright
© 2006 Cambridge University Press

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References

REFERENCES

Adolphs, R., Baron-Cohen, S., & Tranel, D. (2002). Impaired recognition of social emotions following amygdala damage. Journal of Cognitive Neuroscience, 14, 1264–1274.Google Scholar
Adolphs, R., Damasio, H., Tranel, D., & Damasio, A. R. (1996). Cortical systems for the recognition of emotion in facial expressions. Journal of Neuroscience, 16, 7678–7687.Google Scholar
Adolphs, R., & Tranel, D. (2004). Impaired judgments of sadness but not happiness following bilateral amygdala damage. Journal of Cognitive Neuroscience, 16, 453–462.Google Scholar
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357–381.Google Scholar
Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., Jimenez, T., Leight, K., et al. (2000). An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry, 48, 147–162.Google Scholar
Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., & Mintz, J. (1998). Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: An MRI study demonstrating neuroanatomic specificity. Archives of General Psychiatry, 55, 663–664.Google Scholar
Altshuler, L. L., Conrad, A., Hauser, P., Li, X. M., Guze, B. H., Denikoff, K., et al. (1991). Reduction of temporal lobe volume in bipolar disorder: A preliminary report of magnetic resonance imaging. Archives of General Psychiatry, 48, 482–483.Google Scholar
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: Author.
Axelson, D., Birmaher, B., Strober, M., Gill, M. K., Valeri, S., Chiappetta, L., et al. (in press). Phenomenology of children and adolescents with bipolar spectrum disorders. Archives of General Psychiatry.
Barrett, J., Pike, G. B., & Paus, T. (2004). The role of the anterior cingulate cortex in pitch variation during sad affect. European Journal of Neuroscience, 19, 458–464.Google Scholar
Bartels, A., & Zeki, S. (2004). The neural correlates of maternal and romantic love. Neuroimage, 21, 1155–1166.Google Scholar
Baxter, M. G., & Murray, E. A. (2002). The amygdala and reward. Nature Reviews. Neuroscience, 3, 563–573.Google Scholar
Baxter, M. G., Parker, A., Lindner, C. C., Izquierdo, A. D., & Murray, E. A. (2000). Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex. Journal of Neuroscience, 20, 4311–4319.Google Scholar
Bhangoo, R. K., Dell, M. L., Towbin, K., Myers, F. S., Lowe, C. H., Pine, D. S., et al. (2003). Clinical correlates of episodicity in juvenile mania. Journal of Child and Adolescent Psychopharmacology, 13, 507–514.Google Scholar
Biederman, J., Faraone, S. V., Wozniak, J., Mick, E., Kwon, A., & Aleardi, M. (2004). Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years. Journal of Affective Disorders, 82(Suppl. 1), S45–S58.Google Scholar
Biederman, J., Klein, R. G., Pine, D. S., & Klein, D. F. (1998). Resolved: Mania is mistaken for ADHD in prepubertal children. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 1091–1096.Google Scholar
Birmaher, B., Axelson, D., Strober, M., Gill, M. K., Valeri, S., Chiappetta, L., et al. (2006). Clinical course of children and adolescents with bipolar spectrum disorders. Archives of General Psychiatry, 63, 175–183.Google Scholar
Birmaher, B., Kennah, A., Brent, D., Ehmann, M., Bridge, J., & Axelson, D. (2002). Is bipolar disorder specifically associated with panic disorder in youths? Journal of Clinical Psychiatry, 63, 414–419.Google Scholar
Blair, R. J. (2004). The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cognition, 55, 198–208.Google Scholar
Blair, R. J., Colledge, E., & Mitchell, D. G. (2001). Somatic markers and response reversal: Is there orbitofrontal cortex dysfunction in boys with psychopathic tendencies? Journal of Abnormal Child Psychology, 29, 499–511.Google Scholar
Blair, R. J., Morris, J. S., Frith, C. D., Perrett, D. I., & Dolan, R. J. (1999). Dissociable neural responses to facial expressions of sadness and anger. Brain, 122 (Pt. 5), 883–893.Google Scholar
Blumberg, H. P., Fredericks, C. A., Wang, F., Kalmar, J. H., Spender, L., Papademetris, X., et al. (2005). Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders, 7, 570–576.Google Scholar
Blumberg, H. P., Kaufman, J., Martin, A., Charney, D. S., Krystal, J. H., & Peterson, B. S. (2004). Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder. Annals of the New York Academy of Sciences, 1021, 376–383.Google Scholar
Blumberg, H. P., Kaufman, J., Martin, A., Whiteman, R., Zhang, J. H., Gore, J. C., et al. (2003). Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry, 60, 1201–1208.Google Scholar
Blumberg, H. P., Leung, H. C., Skudlarski, P., Lacadie, C. M., Fredericks, C. A., Harris, B. C., et al. (2003). A functional magnetic resonance imaging study of bipolar disorder: State- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry, 60, 601–609.Google Scholar
Blumberg, H. P., Martin, A., Kaufman, J., Leung, H. C., Skudlarski, P., Lacadie, C., et al. (2003). Frontostriatal abnormalities in adolescents with bipolar disorder: Preliminary observations from functional MRI. American Journal of Psychiatry, 160, 1345–1347.Google Scholar
Botvinick, M. M., Cohen, J. D., & Carter, C. S. (2004). Conflict monitoring and anterior cingulate cortex: An update. Trends in Cognitive Science, 8, 539–546.Google Scholar
Brambilla, P., Harenski, K., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E., et al. (2003). MRI investigation of temporal lobe structures in bipolar patients. Journal of Psychiatric Ressearch, 37, 287–295.Google Scholar
Braver, T. S., Barch, D. M., Gray, J. R., Molfese, D. L., & Snyder, A. (2001). Anterior cingulate cortex and response conflict: Effects of frequency, inhibition and errors. Cerebral Cortex, 11, 825–836.Google Scholar
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., et al. (1996). Response and habituation of the human amygdala during visual processing of facial expression. Neuron, 17, 875–887.Google Scholar
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., et al. (1997). Acute effects of cocaine on human brain activity and emotion 2. Neuron, 19, 591–611.Google Scholar
Bunge, S. A., Dudukovic, N. M., Thomason, M. E., Vaidya, C. J., & Gabrieli, J. D. (2002). Immature frontal lobe contributions to cognitive control in children: Evidence from fMRI. Neuron, 33, 301–311.Google Scholar
Calarge, C., Andreasen, N. C., & O'Leary, D. S. (2003). Visualizing how one brain understands another: A PET study of theory of mind. American Journal of Psychiatry, 160, 1954–1964.Google Scholar
Carlson, G. A. (1998). Mania and ADHD: Comorbidity or confusion. Journal of Affective Disorders, 51, 177–187.Google Scholar
Carlson, G. A., Jensen, P. S., Findling, R. L., Meyer, R. E., Calabrese, J., DelBello, M. P., et al. (2003). Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: Report of a consensus conference. Journal of Child and Adolescent Psychopharmacology, 13, 13–27.Google Scholar
Carlson, G. A., & Strober, M. (1978). Manic-depressive illness in early adolescence. A study of clinical and diagnostic characteristics in six cases. Journal of the American Academy of Child Psychiatry, 17, 138–153.Google Scholar
Carter, C. S., Macdonald, A. M., Botvinick, M., Ross, L. L., Stenger, V. A., Noll, D., et al. (2000). Parsing executive processes: Strategic vs. evaluative functions of the anterior cingulate cortex. Proceedings of the National Academy of Sciences of the USA, 97, 1944–1948.Google Scholar
Casey, B. J., Durston, S., & Fossella, J. A. (2001). Evidence for a mechanistic model of cognitive control. Clinical Neuroscience Research, 1, 267–282.Google Scholar
Casey, B. J., Tottenham, N., & Fossella, J. (2002). Clinical, imaging, lesion, and genetic approaches toward a model of cognitive control. Developmental Psychobiology, 40, 237–254.Google Scholar
Chang, K., Adleman, N., Dienes, K., Barnea-Goraly, N., Reiss, A., & Ketter, T. (2003). Decreased N-acetylaspartate in children with familial bipolar disorder. Biological Psychiatry, 53, 1059–1065.Google Scholar
Chang, K., Adleman, N. E., Dienes, K., Simeonova, D. I., Menon, V., & Reiss, A. (2004). Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: A functional magnetic resonance imaging investigation. Archives in General Psychiatry, 61, 781–792.Google Scholar
Chang, K., Karchemskiy, A., Barnea-Goraly, N., Garrett, A., Simeonova, D. I., & Reiss, A. (2005). Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 565–573.Google Scholar
Chen, B. K., Sassi, R., Axelson, D., Hatch, J. P., Sanches, M., Nicoletti, M., et al. (2004). Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biological Psychiatry, 56, 399–405.Google Scholar
Chen, C. H., Lennox, B., Jacob, R., Calder, A., Lupson, V., Bisbrown-Chippendale, R., et al. (2006). Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: A functional magnetic resonance imaging study. Biological Psychiatry, 59, 31–39.Google Scholar
Clark, L., Cools, R., & Robbins, T. W. (2004). The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning. Brain Cognition, 55, 41–53.Google Scholar
Clark, L., Iversen, S. D., & Goodwin, G. M. (2001). A neuropsychological investigation of prefrontal cortex involvement in acute mania. American Journal of Psychiatry, 158, 1605–1611.Google Scholar
Clark, L., Iversen, S. D., & Goodwin, G. M. (2002). Sustained attention deficit in bipolar disorder. British Journal of Psychiatry, 180, 313–319.Google Scholar
Cole, P. M., Martin, S. E., & Dennis, T. A. (2004). Emotion regulation as a scientific construct: Methodological challenges and directions for child development research. Child Development, 75, 317–333.Google Scholar
Compton, R. J., Banich, M. T., Mohanty, A., Milham, M. P., Herrington, J., Miller, G. A., et al. (2003). Paying attention to emotion: An fMRI investigation of cognitive and emotional stroop tasks. Cognitive, Affective Behavioral Neuroscience, 3, 81–96.Google Scholar
Cools, R., Clark, L., & Robbins, T. W. (2004). Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance. Journal of Neuroscience, 24, 1129–1135.Google Scholar
D'Esposito, M., & Postle, B. R. (1999). The dependence of span and delayed-response performance on prefrontal cortex. Neuropsychologia, 37, 1303–1315.Google Scholar
Dahl, R. E. (2004). Adolescent brain development: A period of vulnerabilities and opportunities. Keynote address. Annals of the New York Academy of Science, 1021, 1–22.Google Scholar
Damasio, H., Grabowski, T., Frank, R., Galaburda, A. M., & Damasio, A. R. (1994). The return of Phineas Gage: Clues about the brain from the skull of a famous patient. Science, 264, 1102–1105.Google Scholar
Davidson, R. J. (2004). What does the prefrontal cortex “do” in affect: Perspectives on frontal EEG asymmetry research. Biological Psychology, 67, 219–234.Google Scholar
Davis, M., & Whalen, P. J. (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry, 6, 13–34.Google Scholar
DelBello, M. P., Zimmerman, M. E., Mills, N. P., Getz, G. E., & Strakowski, S. M. (2004). Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorder, 6, 43–52.Google Scholar
Delgado, M. R., Stenger, V. A., & Fiez, J. A. (2004). Motivation-dependent responses in the human caudate nucleus. Cerebral Cortex, 14, 1022–1030.Google Scholar
Derryberry, D., & Reed, M. A. (1994). Temperament and attention: Orienting toward and away from positive and negative signals. Journal of Personality and Social Psychology, 66, 1128–1139.Google Scholar
Dickstein, D. P., Garvey, M., Pradella, A. G., Greenstein, D. K., Sharp, W. S., Castellanos, F. X., et al. (2005). Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorder. Biological Psychiatry, 58, 517–524.Google Scholar
Dickstein, D. P., Milham, M. P., Nugent, A. C., Drevets, W. C., Charney, D. S., Pine, D. S., et al. (2005). Frontotemporal alterations in pediatric bipolar disorder: Results of a voxel-based morphometry study. Archives of General Psychiatry, 62, 734–741.Google Scholar
Dickstein, D. P., Nelson, E. E., McClure, E. B., Grimley, M. E., Knopf, L., Brotman, M. A., et al. (2006). Cognitive flexibility in phenotypes of pediatric bipolar disorder. Manuscript submitted for publication.
Dickstein, D. P., Rich, B. A., Binstock, A. B., Pradella, A. G., Towbin, K. E., Pine, D. S., et al. (2005). Comorbid anxiety in phenotypes of pediatric bipolar disorder. Journal of Child and Adolescent Psychopharmacology, 15, 534–548.Google Scholar
Dickstein, D. P., Treland, J. E., Snow, J., McClure, E. B., Mehta, M. S., Towbin, K. E., et al. (2004). Neuropsychological performance in pediatric bipolar disorder. Biological Psychiatry, 55, 32–39.Google Scholar
Dilsaver, S. C., Chen, Y. W., Swann, A. C., Shoaib, A. M., Tsai-Dilsaver, Y., & Krajewski, K. J. (1997). Suicidality, panic disorder and psychosis in bipolar depression, depressive-mania and pure-mania. Psychiatry Research, 73, 47–56.Google Scholar
Dittmann, S., Biedermann, N. C., Grunze, H., Hummel, B., Scharer, L. O., Kleindienst, N., et al. (2002). The Stanley Foundation Bipolar Network: Results of the naturalistic follow-up study after 2.5 years of follow-up in the German centres. Neuropsychobiology, 46(Suppl. 1), 2–9.Google Scholar
Drevets, W. C., Ongur, D., & Price, J. L. (1998). Neuroimaging abnormalities in the subgenual prefrontal cortex: Implications for the pathophysiology of familial mood disorders. Molecular Psychiatry, 3, 220–221.Google Scholar
Durston, S., Thomas, K. M., Worden, M. S., Yang, Y., & Casey, B. J. (2002). The effect of preceding context on inhibition: An event-related fMRI study. Neuroimage, 16, 449–453.Google Scholar
Ernst, M., Dickstein, D. P., Munson, S., Eshel, N., Pradella, A. G., Jazbec, S., et al. (2004). Reward-related processes in pediatric bipolar disorder: A pilot study. Journal of Affective Disorders, 82, S89–S101.Google Scholar
Ernst, M., Nelson, E. E., Jazbec, S., McClure, E. B., Monk, C. S., Leibenluft, E., et al. (2005). Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents. Neuroimage, 25, 1279–1291.Google Scholar
Farroni, T., Csibra, G., Simion, F., & Johnson, M. H. (2002). Eye contact detection in humans from birth. Proceedings of the National Academy of Science of the USA, 99, 9602–9605.Google Scholar
Feske, U., Frank, E., Mallinger, A. G., Houck, P. R., Fagiolini, A., Shear, M. K., et al. (2000). Anxiety as a correlate of response to the acute treatment of bipolar I disorder. American Journal of Psychiatry, 157, 956–962.Google Scholar
Fletcher, P. C., Happe, F., Frith, U., Baker, S. C., Dolan, R. J., Frackowiak, R. S., et al. (1995). Other minds in the brain: A functional imaging study of “theory of mind” in story comprehension. Cognition, 57, 109–128.Google Scholar
Fonagy, P., Steele, M., Moran, G., Steele, H., & Higgitt, A. (1993). Measuring the ghost in the nursery: An empirical study of the relation between parents' mental representations of childhood experiences and their infants' security of attachment. Journal of the American Psychoanalytic Association, 41, 957–989.Google Scholar
Forbes, E. E., & Dahl, R. E. (2005). Neural systems of positive affect: Relevance to understanding child and adolescent depression? Development and Psychopathology, 17, 827–850.Google Scholar
Frank, E., Cyranowski, J. M., Rucci, P., Shear, M. K., Fagiolini, A., Thase, M. E., et al. (2002). Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder. Archives of General Psychiatry, 59, 905–911.Google Scholar
Frazier, J. A., Chiu, S., Breeze, J. L., Makris, N., Lange, N., Kennedy, D. N., et al. (2005). Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. American Journal of Psychiatry, 162, 1256–1265.Google Scholar
Freeman, M. P., Freeman, S. A., & McElroy, S. L. (2002). The comorbidity of bipolar and anxiety disorders: Prevalence, psychobiology, and treatment issues. Journal of Affective Disorders, 68, 1–23.Google Scholar
Fuster, J. M. (2000). Prefrontal neurons in networks of executive memory. Brain Research Bulletin, 52, 331–336.Google Scholar
Gauthier, I., Tarr, M. J., Anderson, A. W., Skudlarski, P., & Gore, J. C. (1999). Activation of the middle fusiform “face area” increases with expertise in recognizing novel objects. Nature Neuroscience, 2, 568–573.Google Scholar
Geller, B., Bolhofner, K., Craney, J. L., Williams, M., DelBello, M. P., & Gundersen, K. (2000). Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype. Journal of the American Academy of Child & Adolescent Psychiatry, 39, 1543–1548.Google Scholar
Geller, B., Tillman, R., Craney, J. L., & Bolhofner, K. (2004). Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Archives of General Psychiatry, 61, 459–467.Google Scholar
Geller, B., Williams, M., Zimerman, B., Frazier, J., Beringer, L., & Warner, K. L. (1998). Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. Journal of Affective Disorders, 51, 81–91.Google Scholar
Geller, B., Zimerman, B., Williams, M., DelBello, M. P., Bolhofner, K., Craney, J. L., et al. (2002). DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. Journal of Child and Adolescent Psychopharmacology, 12, 11–25.Google Scholar
Giedd, J. N. (2004). Structural magnetic resonance imaging of the adolescent brain. Annals of the New York Academy of Sciences, 1021, 77–85.Google Scholar
Gobbini, M. I., Leibenluft, E., Santiago, N., & Haxby, J. V. (2004). Social and emotional attachment in the neural representation of faces. Neuroimage, 22, 1628–1635.Google Scholar
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., et al. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the USA, 101, 8174–8179.Google Scholar
Goldman-Rakic, P. S. (1987). Development of cortical circuitry and cognitive function. Child Development, 58, 601–622.Google Scholar
Gorrindo, T., Blair, R. J., Budhani, S., Dickstein, D. P., Pine, D. S., & Leibenluft, E. (2005). Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. American Journal of Psychiatry, 162, 1975–1977.Google Scholar
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003). Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science, 301, 1104–1107.Google Scholar
Gur, R. C., Turetsky, B. I., Matsui, M., Yan, M., Bilker, W., Hughett, P., et al. (1999). Sex differences in brain gray and white matter in healthy young adults: Correlations with cognitive performance. Journal of Neuroscience, 19, 4065–4072.Google Scholar
Hariri, A. R., Bookheimer, S. Y., & Mazziotta, J. C. (2000). Modulating emotional responses: Effects of a neocortical network on the limbic system. Neuroreport, 11, 43–48.Google Scholar
Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146–152.Google Scholar
Harpold, T. L., Wozniak, J., Kwon, A., Gilbert, J., Wood, J., Smith, L., et al. (2005). Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents. Journal of Affective Disorders, 88, 19–26.Google Scholar
Haruno, M., Kuroda, T., Doya, K., Toyama, K., Kimura, M., Samejima, K., et al. (2004). A neural correlate of reward-based behavioral learning in caudate nucleus: A functional magnetic resonance imaging study of a stochastic decision task. Journal of Neuroscience, 24, 1660–1665.Google Scholar
Hauser, P., Matochik, J., Altshuler, L. L., Denicoff, K. D., Conrad, A., Li, X., et al. (2000). MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders. Journal of Affective Disorders, 60, 25–32.Google Scholar
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2002). Human neural systems for face recognition and social communication. Biological Psychiatry, 51, 59–67.Google Scholar
Henry, C., Van den, B. D., Bellivier, F., Etain, B., Rouillon, F., & Leboyer, M. (2003). Anxiety disorders in 318 bipolar patients: Prevalence and impact on illness severity and response to mood stabilizer. Journal of Clinical Psychiatry, 64, 331–335.Google Scholar
Holland, P. C., & Gallagher, M. (2003). Double dissociation of the effects of lesions of basolateral and central amygdala on conditioned stimulus-potentiated feeding and Pavlovian-instrumental transfer. European Journal of Neuroscience, 17, 1680–1694.Google Scholar
Izquierdo, A., & Murray, E. A. (2004). Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys. Journal of Neurophysiology, 91, 2023–2039.Google Scholar
Johnson, M. H., Dziurawiec, S., Ellis, H., & Morton, J. (1991). Newborns' preferential tracking of face-like stimuli and its subsequent decline. Cognition, 40, 1–19.Google Scholar
Jonkman, L. M., Kemner, C., Verbaten, M. N., Van Engeland, H., Camfferman, G., Buitelaar, J. K. et al. (2000). Attentional capacity, a probe ERP study: Differences between children with attention-deficit hyperactivity disorder and normal control children and effects of methylphenidate. Psychophysiology, 37, 334–346.Google Scholar
Kalin, N. H., Shelton, S. E., Davidson, R. J., & Kelley, A. E. (2001). The primate amygdala mediates acute fear but not the behavioral and physiological components of anxious temperament. Journal of Neuroscience, 21, 2067–2074.Google Scholar
Kanwisher, N., McDermott, J., & Chun, M. M. (1997). The fusiform face area: A module in human extrastriate cortex specialized for face perception. Journal of Neuroscience, 17, 4302–4311.Google Scholar
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980–988.Google Scholar
Kaur, S., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Monkul, E. S., et al. (2005). Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. American Journal of Psychiatry, 162, 1637–1643.Google Scholar
Kerr, N., Dunbar, R. I., & Bentall, R. P. (2003). Theory of mind deficits in bipolar affective disorder. Journal of Affective Disorders, 73, 253–259.Google Scholar
Killgore, W. D., & Yurgelun-Todd, D. A. (2004). Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. Neuroimage, 21, 1215–1223.Google Scholar
Kluver, H., & Bucy, P. C. (1997). Preliminary analysis of functions of the temporal lobes in monkeys. 1939. Journal of Neuropsychiatry and Clinical Neurosciences, 9, 606–620.Google Scholar
Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D. (2000). FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage, 12, 20–27.Google Scholar
Koob, G. F. (1996). Hedonic valence, dopamine and motivation. Molecular Psychiatry, 1, 186–189.Google Scholar
Koski, L., & Paus, T. (2000). Functional connectivity of the anterior cingulate cortex within the human frontal lobe: A brain-mapping meta-analysis. Experimental Brain Research, 133, 55–65.Google Scholar
Koulomzin, M., Beebe, B., Anderson, S., Jaffe, J., Feldstein, S., & Crown, C. (2002). Infant gaze, head, face and self-touch at 4 months differentiate secure vs. avoidant attachment at 1 year: A microanalytic approach. Attachment and Human Development, 4, 3–24.Google Scholar
Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1998). Emotion, motivation, and anxiety: brain mechanisms and psychophysiology. Biological Psychiatry, 44, 1248–1263.Google Scholar
Leckman, J. F., Sholomskas, D., Thompson, W. D., Belanger, A., & Weissman, M. M. (1982). Best estimate of lifetime psychiatric diagnosis: A methodological study. Archives of General Psychiatry, 39, 879–883.Google Scholar
LeDoux, J. (2003). The emotional brain, fear, and the amygdala. Cell and Molecular Neurobiology, 23, 727–738.Google Scholar
LeDoux, J. E., Iwata, J., Cicchetti, P., & Reis, D. J. (1988). Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. Journal of Neuroscience, 8, 2517–2529.Google Scholar
Lehmann, C., Mueller, T., Federspiel, A., Hubl, D., Schroth, G., Huber, O., et al. (2004). Dissociation between overt and unconscious face processing in fusiform face area. Neuroimage, 21, 75–83.Google Scholar
Leibenluft, E., Blair, R. J., Charney, D. S., & Pine, D. S. (2003). Irritability in pediatric mania and other childhood psychopathology. Annals of the New York Academy of Sciences, 1008, 201–218.Google Scholar
Leibenluft, E., Charney, D. S., Towbin, K. E., Bhangoo, R. K., & Pine, D. S. (2003). Defining clinical phenotypes of juvenile mania. American Journal of Psychiatry, 160, 430–437.Google Scholar
Leibenluft, E., Gobbini, M. I., Harrison, T., & Haxby, J. V. (2004). Mothers' neural activation in response to pictures of their children and other children. Biological Psychiatry, 56, 225–232.Google Scholar
Leibenluft, E., Rich, B. A., Vinton, D. T., Nelson, E. E., Fromm, S. J., Berghorst, L. H., et al. (in press). Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. American Journal of Psychiatry.
Lembke, A., & Ketter, T. A. (2002). Impaired recognition of facial emotion in mania. American Journal of Psychiatry, 159, 302–304.Google Scholar
Lennox, B. R., Jacob, R., Calder, A. J., Lupson, V., & Bullmore, E. T. (2004). Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania. Psychology in Medicine, 34, 795–802.Google Scholar
Logan, G. D., Schachar, R. J., & Tannock, R. (1997). Impulsivity and inhibitory control. Psychological Science, 8, 60–64.Google Scholar
Loiselle, D. L., Stamm, J. S., Maitinsky, S., & Whipple, S. C. (1980). Evoked potential and behavioral signs of attentive dysfunctions in hyperactive boys. Psychophysiology, 17, 193–201.Google Scholar
Lyoo, I. K., Kim, M. J., Stoll, A. L., Demopulos, C. M., Parow, A. M., Dager, S. R., et al. (2004). Frontal lobe gray matter density decreases in bipolar I disorder. Biological Psychiatry, 55, 648–651.Google Scholar
MacLeod, C. M., & MacDonald, P. A. (2000). Interdimensional interference in the Stroop effect: Uncovering the cognitive and neural anatomy of attention. Trends in Cognitive Science, 4, 383–391.Google Scholar
Mangun, G. R., & Hillyard, S. A. (1991). Modulations of sensory-evoked brain potentials indicate changes in perceptual processing during visual-spatial priming. Journal of Experimental Psychology: Human Perception and Performance, 17, 1057–1074.Google Scholar
Masi, G., Toni, C., Perugi, G., Mucci, M., Millepiedi, S., & Akiskal, H. S. (2001). Anxiety disorders in children and adolescents with bipolar disorder: A neglected comorbidity. Canadian Journal of Psychiatry, 46, 797–802.Google Scholar
Matsumoto, N., Hanakawa, T., Maki, S., Graybiel, A. M., & Kimura, M. (1999). Role of [corrected] nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner. Journal of Neurophysiology, 82, 978–998.Google Scholar
May, J. C., Delgado, M. R., Dahl, R. E., Stenger, V. A., Ryan, N. D., Fiez, J. A., et al. (2004). Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents. Biological Psychiatry, 55, 359–366.Google Scholar
McClure, E. B., Pope, K., Hoberman, A. J., Pine, D. S., & Leibenluft, E. (2003). Facial expression recognition in adolescents with mood and anxiety disorders. American Journal of Psychiatry, 160, 1172–1174.Google Scholar
McClure, E. B., Treland, J. E., Snow, J., Schmajuk, M., Dickstein, D. P., Towbin, K. E., et al. (2005). Deficits in social cognition and response flexibility in pediatric bipolar disorder. American Journal of Psychiatry, 162, 1644–1651.Google Scholar
McManis, M. H., Bradley, M. M., Berg, W. K., Cuthbert, B. N., & Lang, P. J. (2001). Emotional reactions in children: Verbal, physiological, and behavioral responses to affective pictures. Psychophysiology, 38, 222–231.Google Scholar
Meunier, M., Bachevalier, J., & Mishkin, M. (1997). Effects of orbital frontal and anterior cingulate lesions on object and spatial memory in rhesus monkeys. Neuropsychologia, 35, 999–1015.Google Scholar
Monk, C. S., McClure, E. B., Nelson, E. E., Zarahn, E., Bilder, R. M., Leibenluft, E., et al. (2003). Adolescent immaturity in attention-related brain engagement to emotional facial expressions. Neuroimage, 20, 420–428.Google Scholar
Moore, C. M., Biederman, J., Wozniak, J., Mick, E., Aleardi, M., Wardrop, M., et al. (2006). Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: A proton magnetic resonance spectroscopy study. American Journal of Psychiatry, 163, 316–318.Google Scholar
Nelson, E. E., Leibenluft, E., McClure, E. B., & Pine, D. S. (2005). The social re-orientation of adolescence: A neuroscience perspective on the process and its relation to psychopathology. Psychological Medicine, 35, 163–174.Google Scholar
Nitschke, J. B., Nelson, E. E., Rusch, B. D., Fox, A. S., Oakes, T. R., & Davidson, R. J. (2004). Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their newborn infants. Neuroimage, 21, 583–592.Google Scholar
Nowicki, S., & Duke, M. (1994). Individual differences in the nonverbal communication of affect: The Diagnostic Analysis of Nonverbal Accuracy Scale. Journal of Nonverbal Behavior, 18, 9–35.Google Scholar
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004). Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science, 304, 452–454.Google Scholar
Olvera, R. L., Semrud-Clikeman, M., Pliszka, S. R., & O'Donnell, L. (2005). Neuropsychological deficits in adolescents with conduct disorder and comorbid bipolar disorder: A pilot study. Bipolar Disorder, 7, 57–67.Google Scholar
Pasupathy, A., & Miller, E. K. (2005). Different time courses of learning-related activity in the prefrontal cortex and striatum. Nature, 433, 873–876.Google Scholar
Pearlson, G. D., Barta, P. E., Powers, R. E., Menon, R. R., Richards, S. S., Aylward, E. H., et al. (1997). Ziskind-Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry, 41, 1–14.Google Scholar
Perchet, C., Revol, O., Fourneret, P., Mauguiere, F., & Garcia-Larrea, L. (2001). Attention shifts and anticipatory mechanisms in hyperactive children: An ERP study using the Posner paradigm. Biological Psychiatry, 50, 44–57.Google Scholar
Perez-Edgar, K., & Fox, N. (in press). A behavioral and electrophysiological study of children's selective attention under neutral and affective conditions. Journal of Cognition and Development.
Pessoa, L., McKenna, M., Gutierrez, E., & Ungerleider, L. G. (2002). Neural processing of emotional faces requires attention. Proceedings of the National Academy of Sciences of the USA, 99, 11458–11463.Google Scholar
Pessoa, L., & Ungerleider, L. G. (2004). Neuroimaging studies of attention and the processing of emotion-laden stimuli. Progress in Brain Research, 144, 171–182.Google Scholar
Phillips, M. L., Williams, L. M., Heining, M., Herba, C. M., Russell, T., Andrew, C., et al. (2004). Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. Neuroimage, 21, 1484–1496.Google Scholar
Polich, J., & Herbst, K. L. (2000). P300 as a clinical assay: Rationale, evaluation, and findings. International Journal of Psychophysiology, 38, 3–19.Google Scholar
Posner, M. I., & Rothbart, M. K. (1998). Attention, self-regulation and consciousness. Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences, 353, 1915–1927.Google Scholar
Poznanski, E. O., Cook, S. C., Carroll, B. J., & Corzo, H. (1983). Use of the Children's Depression Rating Scale in an inpatient psychiatric population. Journal of Clinical Psychiatry, 44, 200–203.Google Scholar
Puig-Antich, J., Blau, S., Marx, N., Greenhill, L. L., & Chambers, W. (1978). Prepubertal major depressive disorder: A pilot study. Journal of the American Academy of Child Psychiatry, 17, 695–707.Google Scholar
Rich, B. A., Schmajuk, M., Perez-Edgar, K. E., Pine, D. S., Fox, N. A., & Leibenluft, E. (2005). The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder. Biological Psychiatry, 58, 532–539.Google Scholar
Rich, B. A., Schmajuk, M., Perez-Edgar, K., Pine, D. S., Fox, N. A., & Leibenluft, E. (in press). Frustration elicits different psychophysiological and behavioral responses in pediatric bipolar disorder and severe mood dysregulation. American Journal of Psychiatry.
Rich, B. A., Vinton, D. T., Roberson-Nay, R., Hommer, R. E., Berghorst, L. H., McClure, E. B., et al. (2006). Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proceedings of the National Academy of Science of the USA, 103, 8900–8905.Google Scholar
Risinger, R. C., Salmeron, B. J., Ross, T. J., Amen, S. L., Sanfilipo, M., Hoffmann, R. G., et al. (2005). Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage, 26, 1097–1108.Google Scholar
Rogers, R. D., Ramnani, N., Mackay, C., Wilson, J. L., Jezzard, P., Carter, C. S., et al. (2004). Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition. Biological Psychiatry, 55, 594–602.Google Scholar
Rolls, E. T. (2000). The orbitofrontal cortex and reward. Cerebral Cortex, 10, 284–294.Google Scholar
Rolls, E. T., O'Doherty, J., Kringelbach, M. L., Francis, S., Bowtell, R., & McGlone, F. (2003). Representations of pleasant and painful touch in the human orbitofrontal and cingulate cortices. Cerebral Cortex, 13, 308–317.Google Scholar
Rubinsztein, J. S., Fletcher, P. C., Rogers, R. D., Ho, L. W., Aigbirhio, F. I., Paykel, E. S., et al. (2001). Decision-making in mania: A PET study. Brain, 124, 2550–2563.Google Scholar
Rubinsztein, J. S., Michael, A., Paykel, E. S., & Sahakian, B. J. (2000). Cognitive impairment in remission in bipolar affective disorder. Psychological Medicine, 30, 1025–1036.Google Scholar
Sanches, M., Roberts, R. L., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., et al. (2005). Developmental abnormalities in striatum in young bipolar patients: A preliminary study. Bipolar Disorder, 7, 153–158.Google Scholar
Sanches, M., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Hatch, J. P., et al. (2005). Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study. Psychiatry Research, 138, 43–49.Google Scholar
Sax, K. W., Strakowski, S. M., Zimmerman, M. E., DelBello, M. P., Keck, P. E., Jr., & Hawkins, J. M. (1999). Frontosubcortical neuroanatomy and the continuous performance test in mania. American Journal of Psychiatry, 156, 139–141.Google Scholar
Schoenbaum, G., Chiba, A. A., & Gallagher, M. (1999). Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. Journal of Neuroscience, 19, 1876–1884.Google Scholar
Schultz, W., Tremblay, L., & Hollerman, J. R. (1998). Reward prediction in primate basal ganglia and frontal cortex. Neuropharmacology, 37, 421–429.Google Scholar
Shaffer, D., Fisher, P., Dulcan, M. K., Davies, M., Piacentini, J., Schwab-Stone, M. E., et al. (1996). The NIMH Diagnostic Interview Schedule for Children Version 2.3 (DISC-2.3): description, acceptability, prevalence rates, and performance in the MECA Study. Methods for the Epidemiology of Child and Adolescent Mental Disorders Study. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 865–877.Google Scholar
Sowell, E. R., Thompson, P. M., Leonard, C. M., Welcome, S. E., Kan, E., & Toga, A. W. (2004). Longitudinal mapping of cortical thickness and brain growth in normal children. Journal of Neuroscience, 24, 8223–8231.Google Scholar
Steger, J., Imhof, K., Coutts, E., Gundelfinger, R., Steinhausen, H. C., & Brandeis, D. (2001). Attentional and neuromotor deficits in ADHD. Developmental Medicine and Child Neurology, 43, 172–179.Google Scholar
Stone, V. E., Baron-Cohen, S., & Knight, R. T. (1998). Frontal lobe contributions to theory of mind. Journal of Cognitive Neuroscience, 10, 640–656.Google Scholar
Strakowski, S. M., DelBello, M. P., Sax, K. W., Zimmerman, M. E., Shear, P. K., Hawkins, J. M., et al. (1999). Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry, 56, 254–260.Google Scholar
Striano, T. (2001). From social expectations to social cognition in early infancy. Bulletin of the Menninger Clinic, 65, 361–370.Google Scholar
Stuss, D. T., & Levine, B. (2002). Adult clinical neuropsychology: Lessons from studies of the frontal lobes. Annual Review of Psychology, 53, 401–433.Google Scholar
Sweeney, J. A., Kmiec, J. A., & Kupfer, D. J. (2000). Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery. Biological Psychiatry, 48, 674–684.Google Scholar
Thompson, R. A. (1994). Emotion regulation: A theme in search of definition. Monographs of the Society for Research in Child Development, 59, 25–52.Google Scholar
Thorpe, S. J., Rolls, E. T., & Maddison, S. (1983). The orbitofrontal cortex: neuronal activity in the behaving monkey. Experimental Brain Research, 49, 93–115.Google Scholar
Trepagnier, C., Sebrechts, M. M., & Peterson, R. (2002). Atypical face gaze in autism. Cyberpsychology Behavior, 5, 213–217.Google Scholar
Ungerleider, L. G., Courtney, S. M., & Haxby, J. V. (1998). A neural system for human visual working memory. Proceedings of the National Academy of Sciences of the USA, 95, 883–890.Google Scholar
Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D., et al. (2002). “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse, 44, 175–180.Google Scholar
Weissman, M. M., & Myers, J. K. (1978). Affective disorders in a US urban community: The use of research diagnostic criteria in an epidemiological survey. Archives in General Psychiatry, 35, 1304–1311.Google Scholar
Wilens, T. E., Biederman, J., Millstein, R. B., Wozniak, J., Hahesy, A. L., & Spencer, T. J. (1999). Risk for substance use disorders in youths with child- and adolescent-onset bipolar disorder. Jouranl of the American Academy of Child and Adolescent Psychiatry, 38, 680–685.Google Scholar
Wilke, M., Kowatch, R. A., DelBello, M. P., Mills, N. P., & Holland, S. K. (2004). Voxel-based morphometry in adolescents with bipolar disorder: First results. Psychiatry Research, 131, 57–69.Google Scholar
Williams, M. A., Morris, A. P., McGlone, F., Abbott, D. F., & Mattingley, J. B. (2004). Amygdala responses to fearful and happy facial expressions under conditions of binocular suppression. Journal of Neuroscience, 24, 2898–2904.Google Scholar
Wozniak, J., Biederman, J., Kiely, K., Ablon, J. S., Faraone, S. V., Mundy, E., et al. (1995). Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 867–876.Google Scholar
Zald, D. H., Boileau, I., El Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S., et al. (2004). Dopamine transmission in the human striatum during monetary reward tasks. Journal of Neuroscience, 24, 4105–4112.Google Scholar
Zink, C. F., Pagnoni, G., Martin-Skurski, M. E., Chappelow, J. C., & Berns, G. S. (2004). Human striatal responses to monetary reward depend on saliency. Neuron, 42, 509–517.Google Scholar