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What's New in the Medical Management of Pediatric Epilepsy?

  • Elaine C. Wirrell (a1)


Epilepsy affects approximately 45 per 100,000 children per year. While many cases respond favorably to antiepileptic therapy, approximately 20% will prove to be medically intractable. This paper reviews some of the recently identified important metabolic and autoimmune etiologies for which there are specific therapies. Additionally, newer antiepileptic medications, including rufinamide, lacosamide, retigabine, eslicarbazepine and brivaracetam and newer dietary options, including the modified Atkins diet and low-glycemic index diet are discussed.


L'épilepsie atteint environ 45 enfants par 100 000 annuellement. Bien que plusieurs patients répondent favorablement au traitement antiépileptique, environ 20% ont une épilepsie pharmacorésistante. Cet article revoit certaines des étiologies métaboliques et autoimmunes importantes identifiées récemment, pour lesquelles il existe un traitement spécifique. De plus, nous traitons des nouveaux médicaments antiépileptiques dont le rufinamide, le lacosamide, la rétigabine, l'eslicarbazépine et le brivaracetam et de nouvelles options diététiques dont le régime Atkins modifié et la diète à indice glycémique faible.

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Corresponding author

Child and Adolescent Neurology, Mayo Clinic, 200 First St SW, Rochester, Minnesota, 55905, USA. Email:


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