Hostname: page-component-848d4c4894-ttngx Total loading time: 0 Render date: 2024-05-23T01:39:19.139Z Has data issue: false hasContentIssue false

Variant Alzheimer's Disease with Spastic Paraparesis and Supranuclear Gaze Palsy

Published online by Cambridge University Press:  23 September 2014

Namita Sinha*
Affiliation:
Division of Anatomical Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia
David Grimes
Affiliation:
Department of Neurology, Univerity of Ottawa, Ottawa
Shinya Tokuhiro
Affiliation:
Center for Research of Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Toronto, Ontario, Canada
Christine Sato
Affiliation:
Center for Research of Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Toronto, Ontario, Canada
Ekaterina Rogaeva
Affiliation:
Center for Research of Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Toronto, Ontario, Canada
John Woulfe
Affiliation:
Department of Pathology and Laboratory Medicine, Univerity of Ottawa, Ottawa
*
Division of Anatomical Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Mackenzie Building, 5788 University Avenue, Halifax, Nova Scotia, B3H 1V8, Canada. Email: drnamitasinha1@gmail.com.
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Brief Communications
Copyright
Copyright © The Canadian Journal of Neurological 2013

References

1. Rogaeva, E. The solved and unsolved mysteries of the genetics of early-onset Alzheimer’s disease. Neuromol Med. 2002;2(1):110.CrossRefGoogle ScholarPubMed
2. Rogaeva, E, Bergeron, C, Sato, C, et al. PS1 Alzheimer’s disease family with spastic paraplegia: the search for a gene modifier. Neurology. 2003;61(7):1005–7.CrossRefGoogle ScholarPubMed
3. Hanein, S, Martin, E, Boukhris, A, et al. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. Am J Hum Genet. 2008;82(4):9921002.CrossRefGoogle ScholarPubMed
4. O’Riordan, S, McMonagle, P, Janssen, JC, et al. Presenilin-1 mutation (E280G), spastic paraparesis, and cranial MRI white-matter abnormalities. Neurology. 2002;59(7):110810 CrossRefGoogle ScholarPubMed
5. Grewal, KK, Stefanelli, MG, Meijer, IA, Hand, CK, Rouleau, GA, Ives, EJ. A founder effect in three large Newfoundland families with a novel clinically variable spastic ataxia and supranuclear gaze palsy. Am J Med Genet A. 2004;131(3):249–54.CrossRefGoogle ScholarPubMed