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A Theory of the Mechanism of Cerebral Vasospasm and Its Reversal, the Role of Calcium and Cyclic AMP

Published online by Cambridge University Press:  18 September 2015

Eric W. Peterson  and
Richard Leblanc
Eric W. Peterson*
Affiliation:
Division of Neurosurgery, University of Ottawa, Medical School
Richard Leblanc
Affiliation:
Division of Neurosurgery, University of Ottawa, Medical School
*
703-1081 Carling Avenue, Ottawa, Ontario KIY 4G2 Canada
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It is proposed that the basic mechanism of vasospasm which sometimes follows subarachnoid hemorrhage is dependent on increased free intracellular calcium ion produced by spasmogens from closely applied extravasated blood. Relaxation of this spasm occurs when the intracellular cyclic AMP levels are raised, resulting in sequestration of calcium ion by the vascular smooth muscle cell sarcoplasmic reticulum.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 4 , November 1976 , pp. 223 - 226
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

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