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Striatonigral Degeneration: Iron Deposition in Putamen Correlates with the Slit-like Void Signal of Magnetic Resonance Imaging

Published online by Cambridge University Press:  18 September 2015

Anthony E. Lang
Affiliation:
Morton and Gloria Shulman Movement Disorder Centre Division of Neurology and Department of Pathology (Neuropathology)
Terry Curran
Affiliation:
Morton and Gloria Shulman Movement Disorder Centre Division of Neurology and Department of Pathology (Neuropathology)
John Provias
Affiliation:
The Toronto Hospital, Toronto
Catherine Bergeron
Affiliation:
The Toronto Hospital, Toronto
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Abstract:

We report three patients with striatonigral degeneration highlighting the correlation between magnetic resonance imaging (MRI) and the pathological changes. The “slit-like void signal” observed in the putamen is typical of striatonigral degeneration and can be used to assist diagnosis during life. Our histochemical studies support the concept that increased iron deposition in the putamen is responsible for this MRI picture.

Résumé:

Résumé:

Dégénérescence striatonigrale: les dépôts de fer dans le putamen sont córreles au signal (“slit-like void”) de l’imagerie par résonance magnétique. Nous rapportons les cas de trois patients atteints de dégénérescence striatonigrale qui illustrent la corrélation qui existe entre l’imagerie par résonance magnétique nucléaire (RMN) et les changements anatomopathologiques. Le signal (“slit-like void”) observé dans le putamen est typique de la dégénérescence striatonigrale et peut être utilisé pour aider au diagnostic du vivant du patient. Nos études histochimiques appuient le concept que des dépôts accrus de fer dans le putamen sont responsables de cette image à la RMN.

Type
Original Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

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