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Stereopsis in Drug Naïve Parkinson's Disease Patients

Published online by Cambridge University Press:  02 December 2014

Seung-Hyun Kim
Affiliation:
Department of Ophthalmology, Korea University College of Medicine at Guro Hospital, Seoul, Republic of Korea
Ji-Hye Park
Affiliation:
Department of Ophthalmology, Korea University College of Medicine at Guro Hospital, Seoul, Republic of Korea
Yu Hwan Kim
Affiliation:
Department of Neurology, Korea University College of Medicine at Guro Hospital, Seoul, Republic of Korea
Seong-Beom Koh*
Affiliation:
Department of Neurology, Korea University College of Medicine at Guro Hospital, Seoul, Republic of Korea
*
Department of Neurology, Korea University College of Medicine at Guro Hospital, #80 Guro-2-Dong, Guro-Gu, Seoul, Republic of Korea.
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Abstract

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Background:

Motor deficits associated with Parkinson's disease (PD) have been well described, yet little attention has been paid to non-motor symptoms, especially cortical visual dysfunction. We investigated stereopsis, as well as the relationship between stereopsis and other cognitive function, in a sample of PD patients.

Methods:

We used Titmus stereotest plates for assessing stereopsis. Fifty-nine subjects (29 PD patients and 30 normal controls) were included in this study. The included patients underwent a neurological examination, clinical rating scale and neuropsychological tests.

Results:

Drug naïve PD patients showed decreased stereopsis on the Titmus fly stereopsis test (Pearson χ2=23.80, p<0.001) compared to PD patients with normal stereopsis. The Hoehn-Yahr stages and Unified Parkinson's Disease Rating Scale motor scores were significantly higher in patients with PD with abnormal stereopsis than in patients with PD with normal stereopsis (p=0.026; p=0.046). The frequency of abnormal visual perception/constructive function was greater in patients with PD with abnormal stereopsis compared to patients with PD with normal stereopsis (Pearson χ2=5.11, p=0.024).

Conclusion:

These findings suggest that stereopsis deficits and visual perception/constructive dysfunction are common in de novo PD patients.

Type
Original Article
Copyright
Copyright © The Canadian Journal of Neurological 2011

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