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Sodium Valproate in the Treatment of the Intractable Childhood Epileptic

  • D.L. Keene (a1), K. Metrakos (a1), G.V. Watters (a1) and A. Sherwin (a1)

Summary:

Sixty-five children with seizure disorders, who had been treated with multiple anticonvulsants but were poorly controlled, were selected from the Montreal Children’s Hospital Convulsive Disorder Clinic and Neurology Service and were treated with sodium valproate (valproate). All types of seizure disorders were included in the group.

Rapid oral absorption of the drug lead to peak plasma levels in one to three hours (later peaks occurring if administered after meals). A mean plasma half-life of 12.8 hours was calculated. Correlation between oral dose and plasma levels was poor. The side effects which occurred in this study were trivial. Drug interactions occurred with phenobarbital, diphenylhydantoin and clonazepam.

Sixty percent of patients had a greater than 50% reduction in seizure frequency with sodium valproate, but the best response was in generalized absence seizures. Since all types of seizures responded to some degree, a trial of sodium valproate is warranted in intractable seizure disorders of childhood regardless of classification.

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Copyright

Corresponding author

Children’s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1

References

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Barnes, S.E. and Bower, S.E. – “Sodium Valproate in the Treatment of Intractable Childhood Epilepsy” – Develop Med. Child. Neurol. 17:175 (1975).
Bruni, J., Wilder, B.J., Perchalski, R.J., Hammond, E.J., and Villareal, H.J. – “Valproic Acid and Plasma Levels of Phenobarbital” – Neurol. (Minneal) 1:94 (1980).
Bruni, J., Wilder, B.J., Willmore, L.J., and Barbour, B. – “Valproic Acid Plasma Levels of Phenytoin-Neurol(Minneap) 29:904 (1979).
Carraz, G., Fau, R., Chateau, R. and Bonnin, J. – “Communications à propos des premiers essais cliniques sur L’activité anti-épileptique de L’acid n-dipropylacétique (sel de Na)Ann Med. Psychol 122:577 (1964).
Covanis, A. and Jeavons, P.M. – “Once Daily Sodium Valproate in the Treatment of Epilepsy” – Devel. Med. Child. Neurol. 22:204 (1980).
Gerber, N., Dickinson, R.G., Harland, R.C., Lynn, R.K., Houghton, D., Antonia, J.I. and Schmishock, J.C. – “Reye-like Syndrome Associated with Valproic Acid TherapyJ. Ped. 95:142 (1979).
Haigh, D. and Forsythe, W.I. – “The Treatment of Childhood Epilepsy with Sodium Valproate” – Develop. Med. Child. Neurol. 17:743 (1975).
Hassan, M.N., Laljee, H.C.K., and Parsonage, M.J. – “Sodium Valproate in the Treatment of Resistant Epilepsy” – Acta Neurol Scand. 54:209 (1976).
Jeavons, P. and Clark, J.E. – “Sodium Valproate in Treatment of Epilepsy” – Brit. Med. J. 2:584 (1974).
Jeavons, P.M., Clark, J.E. and Maheshwasi, M.C. – “The Treatment of Generalized Epilepsies on Valproate (Epilim)Devel. Med. Child. Neurol. 19:9 (1977).
Meunier, H., Carraz, G., Neunier, Y., Eymard, P. and Aimard, M.Proprites” pharmacodynamiques de l’acid n-dipropylacetique-Therapie 18:435 (1964).
Odusote, K. and Sherwin, A. – “A Simple Direct Extraction Method for gas-liquid chromatographic Determination of Valproic Acid in Plasma” – Therapeutic Drug Monitoring 3:103 (1981).
Pinder, R.M., Brodgen, R.N., Speight, T.M. and Avery, G.S.Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy” – Drugs 13:81 (1977).
Richens, A. and Ahmad, S. – “Controlled Trial of Sodium Valproate in Severe Epilepsy” – Brit Med. J. 1:255 (1975).
Ruuskanen, I., Kilpelainen, J.O. and Rickkinen, P.J. – “Side Effects of Sodium Valproate during long-term Treatment in Epilepsy” – Acta. Neurol. Scand. 60:125 (1979).
Sherard, E.S., Steinman, G. and Couri, D. – “Treatment of Childhood Epilepsy with Valproic Acid: Results of the First 100 Patients in a 6 month Trial” – Neurol (Minneap) 30:31 (1980).
Sillanpaa, M. and Donner, M. – “Experiences on the use of Dipropylacetate in the Treatment of Childhood Epilepsy” – Acta Paediatr. Scand. 65:209 (1976).
Simon, D. and Penvy, J.K. – “Sodium di-N-propylacetate (DPA) in the treatment of Epilepsy, a Review” – Epilepsia 16:549 (1975).
Vining, E.P.G.I., Botsford, E. and Freeman, J.M. – “Valproate Sodium in Refractory Seizures” – Am. J. Dis. Child 133:274 (1979).
Volzke, E. and Doose, H. – “Dipropylacetate (Depakine Ergenyl) in the Treatment of Epilepsy” – Epilepsia (Amst) 14:185 (1973).
Wilder, B.J., Willmore, L.J., Bruni, J. and Villareal, H.J.Valproic Acid interaction with other Anticonvulsant Drugs-Neurol. Minneap 28:892 (1978).

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